Aromasin e Tamoxifene… Scendere un ciclo di steroidi

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Coming off a steroid cycle is a bitch. Nothing new about that. When you're on the juice, you look great, sento benissimo, you're strong as an ox, and you're usually horny as a mother-f#cker! Ma, alas, all good things eventually must come to an end and a steroid cycle is no different.

Ma, bodybuilders have known for a long time that a good post-cycle protocol can make the transition back to being natural a lot easier. And it can help you keep your muscle gains and bring your natural testosterone levels back to where they were before your cycle. Good post cycle therapy can also be used to keep cycle related estrogen levels in check and prevent all the nasty estrogen related side effects.

In this week's EliteFitness.com news we share some of the benefits of an often overlooked post-cycle drug and powerful anti-estrogen - Aromasin. We'll also share with you how to combine it with the old favorite Nolvadex for even better gains-keeping results!

Rationale for the Use of Aromasin with Tamoxifen (Nolvadex) During Post Cycle Therapy

Aromasin (Exemestane) is one of those weird compounds that nobody really knows what to do with. What we generally hear about it makes it very uninteresting… È un inibitore dell'aromatasi di terza generazione (AI) just like Anastrozole and Femera (Letrozolo). Both of those two drugs are very efficient at stopping the conversion of androgens into estrogen, e poiché li abbiamo, Perché perdere tempo con Aromasin? It’s a little harder to get than the other two commonly used aromatase inhibitors, perché non è in alto la domanda, and there’s never been a readily apparent advantage to using it.

E cioe '… consente di affrontare: È imbarazzante-suono. Aromasin non ha molto di un anello ad esso, ed exemestane è peggio. Anastrozole has a bunch of cool abbreviations ("A-dex" or just ‘dex) and even Letrozole is just "Letro" per la maggior parte delle persone. Where’s the cool nickname for Aromasin (exemestane)? A-Sin? E-Stane? Semplicemente non funziona. It’s the black sheep of AIs. E perché abbiamo ancora bisogno di esso quando abbiamo letrozolo, which is by far the most efficient AI for stopping aromatization (the process by which your body converts testosterone into estrogen)? Letro can reduce estrogen levels by 98% o maggiore; clinically a dose as low as 100mcgs has been shown to provide maximum aromatase inhibition (2)!

So why would we need any other AIs? Bene, Innanzitutto, estrogen is necessary for healthy joints (3) così come un sistema immunitario sano (4). Così come liberarsi di 98% of the estrogen in your body for an extended period of time may not be the best of ideas. This may be useful on an extreme cutting cycle, porta a un concorso di bodybuilding, or if you are particularly prone to gyno, but certainly can’t be used safely for extended periods of time without compromising your joints and immune system.

That leaves us with Anastrozole, which isn’t as potent as Letrozole, ma a. 5mgs/day sarà ancora sbarazzarsi di circa la metà (50%) of the estrogen in your body. Problema risolto, destra? Use Anastrozole on your typical cycles, and if you are very prone to gyno or are getting ready for a contest, utilizzare Letro.

Ma per quanto riguarda il ciclo di terapia Post (PCT)?

Penso che a questo punto la maggior parte delle persone sono vendute sull'uso di Nolvadex (Tamoxifen Citrate) invece di Clomid per post ciclo di terapia (PCT), Poiché entrambi competere estrogeni presso il sito del recettore, both increase serum test levels, and both drugs may also alter blood lipid profiles favorably (6). But since 20mgs of Tamoxifen is equal to 150mgs of clomid for purposes of testosterone elevation, FSH e LH, but Tamoxifen doesn’t decrease the LH response to LHRH (6) I think most people agree to Nolvadex’s superiority for PCT.

Aromasin con Nolvadex

Sono sempre stato a favore dell'utilizzo Nolvadex durante PCT, insieme a un'intelligenza artificiale, because reducing estrogen levels has been positively correlated with an increase in testosterone (7) so in my mind, it’s be beneficial to increase testosterone by as many mechanisms as possible while trying to recover your endogenous testosterone levels after a cycle. COSÌ che AI usiamo? Letro o A-dex? Bene, why don’t we just keep using whichever one we used during the cycle, e aggiungere in alcune Nolvadex? purtroppo, Nolvadex will significantly reduce the blood plasma levels of both Letrozole as well as Anastrozole (8). Quindi, se scegliamo di usare uno di loro con la nostra Nolvadex PCT, Ci stiamo buttando via un po' di soldi, come il Nolvadex riduce l'efficacia.

Questo, certamente, è Aromasin entra in, al 20-25mgs/day.

Aromasin, a che la dose, aumenterà i livelli di testosterone di circa 60%, and also help out your free to bound testosterone ratio by lowering levels of Sex Hormone Binding Globulin (SHBG), da circa 20% (12)… SHBG is that nasty enzyme that binds to testosterone and renders it useless for building muscle. Ma che cosa circa usando insieme con Nolvadex per PCT?

Differenza tra tipo-Io e inibitori dell'aromatasi di tipo II

Per capire perché Aromasin può essere utile in combinazione con Nolvadex mentre Letro sia A-dex soffrire ridotta efficacia, we’ll need to first understand the differences between a Type-I and Type-II Aromatase Inhibitor. Inibitori di tipo (come Aromasin) sono composti steroidei in realtà, mentre gli inibitori di tipo II (like Letro and A-dex) sono anti-infiammatori non steroidei. Da qui, androgenic side effects are very possible with Type-I AIs, and they should probably be avoided by women. Certamente, there are some similarities between the two types of AIs…sia di tipo I & tipo II AIs mimica normali substrati (essentially androgens), allowing them to compete with the substrate for access to the binding site on the aromatase enzyme. Dopo questa associazione, the next step is where things differ greatly for the two different types of AI’s. In the case of a type-I AI, l'inibitore non competitivo si lega, and the enzyme initiates a sequence of hydroxylation; this hydroxylation produces an unbreakable covalent bond between the inhibitor and the enzyme protein. Adesso, l'attività dell'enzima è permanentemente bloccato; even if all unattached inhibitor is removed. Aromatase enzyme activity can only be restored by new enzyme synthesis. Adesso, d'altra parte, competitive inhibitors, di tipo chiamato II AI, reversibly bind to the active enzyme site, e una delle due cose può succedere:

1.) o nessun'attività dell'enzima viene attivato o .

2.) l'enzima viene attivato in qualche modo senza effetto. The type II inhibitor can now actually disassociate from the binding site, eventually allowing renewed competition between the inhibitor and the substrate for binding to the site. This means that the effectiveness of competitive aromatase inhibitors depends on the relative concentrations and affinities of both the inhibitor and the substrate, while this is not so for noncompetitive inhibitors. Aromasin è un tipo-io inibitore, vale a dire che una volta ha fatto il suo lavoro, and deactivated the aromatase enzyme, non abbiamo bisogno di piu '. Letrozole and Anastrozole actually need to remain present to continue their effects. Questo è probabilmente perché Nolvadex non altera la farmacocinetica di Aromasin (11).

Conclusione

Prima di chiudere il libro su Aromasin, vale la pena notare che è possibile (e dovrebbe) still use one of the non-steroidal AIs during your cycle to reduce estrogen, Se necessario. Quando si è pronti per PCT, si può poi passare ad Aromasin e ancora sperimentare gli effetti di un'intelligenza artificiale, since there is no cross-over tolerance experienced between steroidal and non-steroidal AIs (9). Poiché si tratta di Aromasin 65% efficiente a sopprimere l'estrogeno (10), it’s certainly a very powerful agent, especially considering you won’t experience reduced effectiveness because of your concurrent use of Nolvadex or from any sort of tolerance developed by using other AIs on your cycle(9). There is also a decent amount of preclinical data suggesting that Aromasin has a beneficial effect on bone mineral metabolism that is not seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are not found in the non-steroidal Letro and A-dex (9).

Finalmente, come stiamo andando a utilizzare Nolvadex per PCT comunque, e noi dobbiamo essere con un'intelligenza artificiale con esso per recupero massimo… I think Aromasin- considerando che è la compatibilità con Nolvadex ed effetti benefici sul profilo del lipido e contenuto minerale dell'osso, has finally stopped being the black sheep of AIs and found a home in our cycles.

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