I'm thinking if I was in a situation where I was out of town and met a cool chick that I clicked with and we both knew there was chemistry between us, it would be hard for me to pass up a night of (protected) passion.
What it boils down to is that it would take a situation deemed too good to pass up for me to have a one night stand....
...mind you, this isn't the same as a situation that's too good to be true.