I try to mix things up every few months.
Right now I'm into heavier sets, lower reps on my major muscle groups - back, chest, quads...
I'll stretch and do a warm up set... then I run about 8 reps, adding weight for each set. Generally runs about 8, 6, 5. I prefer to do the higher weights/lower reps during bulking.
I'm thinking about March I'll start up with going high rep once again. When I do this, I usually pyrimid them. I always try to add weight from set to set (except I'll run 4 sets when I'm going high rep and I'll drop weight on the last set and try to get 10-12 reps). You can get some killer Bi pumps, especially this way.