Vitamin C dose

[anthrax]

Don't take huuuuuge amounts of vitamin C at a time !


Dr. Levine and his colleagues have found that the body's absorption of orally ingested vitamin C decreases as the dose increases.

Thus while 80 per cent of a 100 mg dose is fully absorbed less than 50 per cent of a 1250 mg dose is actually absorbed.
Dr. Levine concludes that doses greater than 500 mg contribute little to plasma or tissue stores. He also estimates that even at doses of 1000 mg it is extremely difficult to achieve a blood plasma concentration much above 100 micromol/L.

Intravenous infusions, on the other hand, can achieve plasma levels as high as 5000 micromol/L with a dose of 5 to 10 grams.

Padayatty, Sebastian J. and Mark Levine. New insights into the
physiology and pharmacology of vitamin C. Canadian Medical Association Journal, Vol. 164, February 6, 2001, pp. 353-55 Hoffer, L. John.

 

[EngiCream]

That's pretty interesting, I was just wondering about this, thanks.

 

[DR. NOE]

Good info, looks like I will need to lower my vitamin c intake per day.

 

[NEWYORK104]

HHHHmmmm.....Looks like ive been taking too much VITAMNIN C...

 

[HumanShell]

no need to lower your vitamin c dose per day....just spread it out into smaller doses.

 

[riskybizz007]

I agree... If i'm going to take 2g of vit.C i'll take 500mg in 4 different times of the day. Great study Anthrax.

 

[HumanShell]

Hmm...doesn't say if this study was done with ascorbic or esterfied Vit-C

 

[EngiCream]

Anyone happen to try the Twin Lab 1000mg Sustained Release Vitamin C???

 

[UNDERGROUND_BUNNY]

I use C-plus citrus bioflavonoid caps by twinlab.2 caps provide 1000mg vit.C / 650mg citrus bioflavonoids complex / 50mg rutin. I take 4 4x's a day. The bioflav.complex makes it all the more potent.

 

[vtec96]

Anthrax, have you seen any articles/studies done with Ester-C (with Calcium Ascorbate) rather than regular ascorbic acid? This would be interesting since ester-C is supposed to be a much more absorbable type.

Also would taking Vit-C 500mg (as above) w/last meal 8pm be a good idea? Thanks... keep the studies comming....

 

[macrophage69alpha]

smaller more frequent dosing is better.. btw- high single doses is not conducive to healthy microflora.

 

[anthrax]

Anthrax, have you seen any articles/studies done with Ester-C (with Calcium Ascorbate) rather than regular ascorbic acid? This would be interesting since ester-C is supposed to be a much more absorbable type.

Here is what I have found on Ester-C :

A recent double-blind study compared the absorption of ascorbic acid alone, ascorbic acid with bioflavonoids and Ester C®. Ascorbic acid and ascorbic acid with added bioflavonoids were as good as or better than Ester C; at no point was Ester C proved superior (JADA, 1994, 94(7):779-81)

I have heard oposite studies on vitamin C
Many of then were stating that regular ascorbic acid was as "good" as Ester-C, buffered, flavonoids, rose hips,..... vit C

 

[HumanShell]

can I get a link on that original article please

 

[anthrax]

I am sorry I don't have more than that abstract

here is the link to JADA: http://www.ada.org/prof/pubs/jada/index.asp

but I can't find that article

 

[Scottyo]

Good info...ive always taken my c's that way...have 500 mg tabs so it just works out anyways

 

[TYPE A]

Good Info

Vit C is water soluble, so you should take it evenly over the day. Everybody has a different threshold of Vitamin C, which is until you get diarrea.
Palus Lining advocated use of high levels of Vitamin C, while others say more than 5oomg per day is a waste and can actually be a pro oxidant...the argument continues! I am not familiar with effects on intestinal flora, as it you would hope it would be practically digested by that time and stomach acids are stronger than ascorbic acid.
I would suggest a daily dose of 2 gms over the entire day and use about 6 gms in times when you
may be run down etc.