Good Info
Vit C is water soluble, so you should take it evenly over the day. Everybody has a different threshold of Vitamin C, which is until you get diarrea.
Palus Lining advocated use of high levels of Vitamin C, while others say more than 5oomg per day is a waste and can actually be a pro oxidant...the argument continues! I am not familiar with effects on intestinal flora, as it you would hope it would be practically digested by that time and stomach acids are stronger than ascorbic acid.
I would suggest a daily dose of 2 gms over the entire day and use about 6 gms in times when you
may be run down etc.