Study showing winstrols activity independent of A/R binding/DNA interaction...

[Andy13]

Important to note that while the substance may have a high affinity for the AR, that doesn't mean that it's particularly antagonistic. Some molecules will bind more or less strongly to the AR and may elicit far different effects based on their structure.

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I'm not so sure I agree with this. Are you saying different hormone/receptor complexes initiate transcription at different DNA locations? As far as I know, the DNA binding domains for transcription factors associated with AR/hormone homodimer are independant of the hormone bound. Or am I wrong?

Andy

 

[THE BOUNCER]

keep posting guys this is a hell of an artical!

 

[21inch_arms]

This one gets my vote for post of the year!!!!!

 

[WannaImpress]

HUCKLEBERRY FINNaplex

HUCKLEBERRY FINNaplex,

excellent post and thanks for explaining it in more common words@ This helps a great deal in my decision for my next cycle! Keep them post coming!

 

[HappyScrappy]

Huck, what i didn't understand was the relationship btwn winstrol
and bezodiazepine receptors. Are they saying that they stimulate
the same receptors? if so, then could it be possible to become
physically addicted to winstrol the way you would to, say, valium?

I'd say bump - but this thing is sticky anyway.

I'd really like to see some more discussion towards this that I'm quoting above.

(great post by the way - this sort of thing makes up for much of the "retardedness" one sees on so much of the rest of the boards here - of course not counting the elite select board or this one at times)

 

[Tuna Guy]

Hmmm, so tren + halo would make a nice little stack.

 

[Unity66]

i never knew that stanozolol has an affinity for the receptors that benzodiazepines work through.........time fo me to do some psych/anabolic research. maybe you will drop me a line huck at [email protected] and paste your source of data on this

that is a strange theory.........but as many know and have stated; ending a cycle with stano usually results in depression. these receptors help us deal with anxiety and social fears.............this is getting more and more interesting both with the winny and the ox!!!!!!!!

Unity66

 

[conan69]

God damn i love this board

you guys have entirely to much time on your hands

 

[The Shadow]

Good info!!

How about a listing of Class I compounds and Class II compounds??

 

[HUCKLEBERRY FINNaplex]

Your wish is my command,lol...

Anabolic Steroids achieve their effects on hypertrophy through different mechanisms,and as such are classified into two different categories,class-I and class-II compounds.I will explain which ones work through which pathway,and how to effectively combine opposing groups to maximize potentiation of one another for explosive growth....

Class-I-These are steroids who's primary influence on anabolism is achieved through aggressive binding and activation of the androgen receptor...Examples of potent class-I's are-Deca-durabolin,primobolan,equipoise,oxandrolone...

Class-II-These are compounds with potent activity independent of A/R binding/activation,and their activity has been monitored in neuron's,microsomes,mitochondria,etc...Examples of potent class-II's are-Anadrol,Dianabol,winstrol,Fluoxymesterone...

Then we have steroids that are potent combination steroids all by themselves(meaning they display influences on growth through both class-I and II activity,and thus are very effective as'stand-alone'anabolic agents as well as forming the 'base' of most steroid stacks)....Two compounds possess this unique characteristic-Trenbelone and Testosterone.Either of these two steroids should form the base of most users stacks,as the cover both A/R and non-A/R mediated mechanisms,and adding to them with either a class-I or II will only potentiate that particular mechanism towards muscular hypertrophy...

Now that we're aware of which compounds work through which mechanism,how do we combine them effectively to maximize each one's potential?As explained above,Testosterone and trenbelone should form the base of any serious steroid stack,but great effects can be had by combining single mechanism steroids from opposing classes....Examples of this type of synergistic combining could be(but are not limited to)

*CUTTING*
Winstrol & Equipoise
Winstrol & Primobolan
Fluoxymesterone & Equipoise or Primobolan

*BULKING*
Deca & Dianabol
Anadrol & Equipoise or Primobolan
Winstrol & deca

And of course,using test or tren as the base compound for either cutting or bulking will only make results that much more explosive.If using test for cutting,an anti-aromitase should be incorporated