It's my second home, actually we have a second home about an hour north, but I spent many of my formative years coming and going in SoBe.....
It is what it is, a playground for tourists who feel the attraction of the tropical nightlife, but to anyone who lives there (or has spent a fair amount of time) it's no different than anywhere else (just warmer).
The hot clubs at the moment are The Delano (in the Ritz), Mynt, The Rok Bar,...these are touristy, the locals hang at Nikki's, Automatic Slims, etc.
The restaraunts change all the time.