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Smoking weed and training/cutting
- Thread starter Marcoparc
- Start date
rocky_road
New member
Marcoparc said:
Of course. Your heart is a muscle too you know.
What if you have a heart attack while in the weight room?
That would suck.
pitbullrocco
New member
biochemically, its been shown that thc temporarily increases cortisol levels and progestin levels only (however, still within normal range).....after so long, all hormone levels are back to original levels.....nothing has proven any affects on test levels....however any chemical that makes your body process it first as a "toxin" will detriment natural test production....
thc will increase the cells ability to store fat....i would worry only if i'm 30%bf and smoking 9 ounces a day....
do a google on "marijuana cortisol progestin"
one interesting note i read said "possibility that noncannabinoid components of marijuana smoke have affinity to the estrogen receptor" when discussing the topic of gynecomastia. interesting if you are interested in controlling estrogen during cycle.....a must read....find it here:
www.ukcia.org/research/EndocrineEffects.pdf
thc will increase the cells ability to store fat....i would worry only if i'm 30%bf and smoking 9 ounces a day....
do a google on "marijuana cortisol progestin"
one interesting note i read said "possibility that noncannabinoid components of marijuana smoke have affinity to the estrogen receptor" when discussing the topic of gynecomastia. interesting if you are interested in controlling estrogen during cycle.....a must read....find it here:
www.ukcia.org/research/EndocrineEffects.pdf
LOL @ anyone saying that weed brings down training.
NOW if u get high before u workout, and u miss the workout, i think its preerty obviousl that weed is to blame.
The studies that show estrogen levels elevated after smoking weed have been disproven. THIS WOULD BE my only worry.
weed smoke hjas no where near the contaminents of cigarete smoke.
Yes it raises BP slightly
Anyone telling you from studies/paper and not from thier own expierince, just doesnt know. The studies are all bullshit about the subject.
BOTH SIDES have bullshit studies, PRO cannabis, or not.
I smoke daily. Maybe even 2x day. Once right after training. And once before sleep basically.
NOW am i saying i could have done better w/ results if i ddint smoke, of course, but would it really make a difference? Prob not.
I bust my ass in the gym, weed relaxes me. Arnold smokes weed. Besides, unlike ciggarets which constrict the lungs, i believe marijuana opens the passageway allowing even more oxygen to be allowed in (trying to remember if i read it, or someone told me)
Smoke on brother.
Arnold Did =]
NOW if u get high before u workout, and u miss the workout, i think its preerty obviousl that weed is to blame.
The studies that show estrogen levels elevated after smoking weed have been disproven. THIS WOULD BE my only worry.
weed smoke hjas no where near the contaminents of cigarete smoke.
Yes it raises BP slightly
Anyone telling you from studies/paper and not from thier own expierince, just doesnt know. The studies are all bullshit about the subject.
BOTH SIDES have bullshit studies, PRO cannabis, or not.
I smoke daily. Maybe even 2x day. Once right after training. And once before sleep basically.
NOW am i saying i could have done better w/ results if i ddint smoke, of course, but would it really make a difference? Prob not.
I bust my ass in the gym, weed relaxes me. Arnold smokes weed. Besides, unlike ciggarets which constrict the lungs, i believe marijuana opens the passageway allowing even more oxygen to be allowed in (trying to remember if i read it, or someone told me)
Smoke on brother.
Arnold Did =]
JKurz1
Banned
Toxicology. 2005 Jan 31;206(3):471-8.
Marijuana extracts possess the effects like the endocrine disrupting chemicals.
Watanabe K, Motoya E, Matsuzawa N, Funahashi T, Kimura T, Matsunaga T, Arizono K, Yamamoto I.
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan. [email protected]
The progesterone 17alpha-hydroxylase activity, which is one of the steroidogenic enzymes in rat testis microsomes, was significantly inhibited by crude marijuana extracts from Delta(9)-tetrahydrocannabinolic acid (THCA)- and cannabidiolic acid (CBDA)-strains. Delta(9)-Tetrahydrocannabinol, cannabidiol and cannabinol also inhibited the enzymatic activity with relatively higher concentration (100-1000 microM). Testosterone 6beta- and 16alpha-hydroxylase activities together with androstenedione formation from testosterone in rat liver microsomes were also significantly inhibited by the crude marijuana extracts and the cannabinoids. Crude marijuana extracts (1 and 10 microg/ml) of THCA strain stimulated the proliferation of MCF-7 cells, although the purified cannabinoids (THC, CBD and CBN) did not show significant effects, such as the extract at the concentration of 0.01-1000 nM. These results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana.
Edit: I made the important sentence bold/underline.
Marijuana extracts possess the effects like the endocrine disrupting chemicals.
Watanabe K, Motoya E, Matsuzawa N, Funahashi T, Kimura T, Matsunaga T, Arizono K, Yamamoto I.
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan. [email protected]
The progesterone 17alpha-hydroxylase activity, which is one of the steroidogenic enzymes in rat testis microsomes, was significantly inhibited by crude marijuana extracts from Delta(9)-tetrahydrocannabinolic acid (THCA)- and cannabidiolic acid (CBDA)-strains. Delta(9)-Tetrahydrocannabinol, cannabidiol and cannabinol also inhibited the enzymatic activity with relatively higher concentration (100-1000 microM). Testosterone 6beta- and 16alpha-hydroxylase activities together with androstenedione formation from testosterone in rat liver microsomes were also significantly inhibited by the crude marijuana extracts and the cannabinoids. Crude marijuana extracts (1 and 10 microg/ml) of THCA strain stimulated the proliferation of MCF-7 cells, although the purified cannabinoids (THC, CBD and CBN) did not show significant effects, such as the extract at the concentration of 0.01-1000 nM. These results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana.
Edit: I made the important sentence bold/underline.
JKurz1
Banned
Marijuana : How it affects building muscle
--------------------------------------------------------------------------------
Here is an abstract I found on PubMed :
Plasma LH are significantly depressed and cortisol significantly elevated after smoking marijuana. Nonsignificant depressions of prolactin, FSH, testosterone and free testosterone and elevation of GH also occurred.
(http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract)
The symptoms i experience after smoking closely resemble side effects of a cortisol spike (munchies, lethargy, slight anxiety). I noticed the relation when i was reading up on cortisol. It lead me to search about marijuana and hormone levels. Sure enough, cortisol, the muscle eating hormone, is elevated, and LH drops. Lowered LH results in lower sperm count. These are temporary effects, generally 24 hours. That means that daily use is catabolic and raises fat storage. Endurance drops. I beleive it will hinder gains. Any educated input is welcome to this thread, thread parrots and moralist please keep it to yourself. Thnx,
--------------------------------------------------------------------------------
Here is an abstract I found on PubMed :
Plasma LH are significantly depressed and cortisol significantly elevated after smoking marijuana. Nonsignificant depressions of prolactin, FSH, testosterone and free testosterone and elevation of GH also occurred.
(http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract)
The symptoms i experience after smoking closely resemble side effects of a cortisol spike (munchies, lethargy, slight anxiety). I noticed the relation when i was reading up on cortisol. It lead me to search about marijuana and hormone levels. Sure enough, cortisol, the muscle eating hormone, is elevated, and LH drops. Lowered LH results in lower sperm count. These are temporary effects, generally 24 hours. That means that daily use is catabolic and raises fat storage. Endurance drops. I beleive it will hinder gains. Any educated input is welcome to this thread, thread parrots and moralist please keep it to yourself. Thnx,
JKurz1
Banned
Put it this way:
I am sure literally EVERYONE here has done this at one time or another. At one time in my life, long ago in my music making days, we used to use this as a way to "open up the paths of creativity" and get the "freestyle" going. Others use it for medicinal purposes, or in other social settings for whatever reasons. (Relaxation, video games, etc.)
I feel though however, once you truly "grow up" and have a grasp on what it is you really want to do in life, you can no longer afford the "fog" that this substance leaves you in. It's a hallucinogen/depressant, so you are basically fooling yourself into thinking you are being creative, doing something you couldn't otherwise do if you were sober, etc. It's a catch 22, and yes it may be fun at times, but in the long/big scheme of things, the negatives HIGHLY outweigh the positives.
Now, put this substance into the realm of fitness, and there is NO question that it does FAR more damage than good. From everything from motivation, to estrogen, to the munchies, to oxygen capacity, to brain cells, etc. So, I am not trying to be the "father figure" here or preach to you all, but seriously consider what it is you wish to accomplish in life and if you can truly get there while partaking with this substance.
If you can, more power to you, but often times it's very mis-leading and you are a better more outgoing person w/out it. You can attain more w/out it, that's for sure, and that's 100% real.
I am sure literally EVERYONE here has done this at one time or another. At one time in my life, long ago in my music making days, we used to use this as a way to "open up the paths of creativity" and get the "freestyle" going. Others use it for medicinal purposes, or in other social settings for whatever reasons. (Relaxation, video games, etc.)
I feel though however, once you truly "grow up" and have a grasp on what it is you really want to do in life, you can no longer afford the "fog" that this substance leaves you in. It's a hallucinogen/depressant, so you are basically fooling yourself into thinking you are being creative, doing something you couldn't otherwise do if you were sober, etc. It's a catch 22, and yes it may be fun at times, but in the long/big scheme of things, the negatives HIGHLY outweigh the positives.
Now, put this substance into the realm of fitness, and there is NO question that it does FAR more damage than good. From everything from motivation, to estrogen, to the munchies, to oxygen capacity, to brain cells, etc. So, I am not trying to be the "father figure" here or preach to you all, but seriously consider what it is you wish to accomplish in life and if you can truly get there while partaking with this substance.
If you can, more power to you, but often times it's very mis-leading and you are a better more outgoing person w/out it. You can attain more w/out it, that's for sure, and that's 100% real.
Lifterforlife
New member
Brand new research is pointing to pot as being just as dangerous as cigarettes, earlier studies many things were overlooked. I think Jkurz for once 
has a valid point. At some point in your life, it is time to put priorities in order and grow up.
has a valid point. At some point in your life, it is time to put priorities in order and grow up.Lifterforlife
New member
JKurz1 said:
Marijuana Good for the Arteries
By James Joyner
A Geneva University study shows that THC, the active ingredient in marijuana, helps prevent coronary artery disease in mice. This is good news for dope smoking mice, indeed.
Cannabis Compound Slows Artery Disease in Mice (Reuters)
An active ingredient in cannabis can ease inflammation and slow the progression of coronary artery disease in mice, and possibly humans, researchers said on Wednesday. Daily low doses of the ingredient, THC, prevented atherosclerosis, a primary cause of heart disease and stroke in western countries, without producing the associated high. “We have proven that very low doses of cannabis therapy will have an anti-inflammatory effect that will slow the progression of atherosclerosis in mice,” said Dr Francois Mach, of Geneva University Hospital in Switzerland.
By James Joyner
A Geneva University study shows that THC, the active ingredient in marijuana, helps prevent coronary artery disease in mice. This is good news for dope smoking mice, indeed.
Cannabis Compound Slows Artery Disease in Mice (Reuters)
An active ingredient in cannabis can ease inflammation and slow the progression of coronary artery disease in mice, and possibly humans, researchers said on Wednesday. Daily low doses of the ingredient, THC, prevented atherosclerosis, a primary cause of heart disease and stroke in western countries, without producing the associated high. “We have proven that very low doses of cannabis therapy will have an anti-inflammatory effect that will slow the progression of atherosclerosis in mice,” said Dr Francois Mach, of Geneva University Hospital in Switzerland.
Marijuana: interaction with the estrogen receptor
MA Sauer, SM Rifka, RL Hawks, GB Cutler and DL Loriaux
Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed marijuana smoke also competed with estradiol for its receptor. Pure delta 9- tetrahydrocannabinol, however, did not interact with the estrogen receptor. Ten delta 9-tetrahydrocannabinol metabolites also failed to compete with estradiol for its receptor. Of several other common cannabinoids tested, only cannabidiol showed any estrogen receptor binding. This was evident only at very high concentrations of cannabidiol. Apigenin, the aglycone of a flavinoid phytoestrogen found in cannabis, displayed high affinity for the estrogen receptor. To assess the biological significance of these receptor data, estrogen activity was measured in vivo with the uterine growth bioassay, using immature rats. Cannabis extract in large doses exhibited neither estrogenic nor antiestrogenic effects. Thus, although estrogen receptor binding activity was observed in crude marijuana extract, marijuana smoke condensate and several known components of cannabis, direct estrogenic activity of cannabis extract could not be demonstrated in vivo.
MA Sauer, SM Rifka, RL Hawks, GB Cutler and DL Loriaux
Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed marijuana smoke also competed with estradiol for its receptor. Pure delta 9- tetrahydrocannabinol, however, did not interact with the estrogen receptor. Ten delta 9-tetrahydrocannabinol metabolites also failed to compete with estradiol for its receptor. Of several other common cannabinoids tested, only cannabidiol showed any estrogen receptor binding. This was evident only at very high concentrations of cannabidiol. Apigenin, the aglycone of a flavinoid phytoestrogen found in cannabis, displayed high affinity for the estrogen receptor. To assess the biological significance of these receptor data, estrogen activity was measured in vivo with the uterine growth bioassay, using immature rats. Cannabis extract in large doses exhibited neither estrogenic nor antiestrogenic effects. Thus, although estrogen receptor binding activity was observed in crude marijuana extract, marijuana smoke condensate and several known components of cannabis, direct estrogenic activity of cannabis extract could not be demonstrated in vivo.
Cannabis Improves Night Vision, Study Says
Missoula, MT: Administration of cannabis improves night vision in a dose-dependent manner, according to the findings of a case study to be published in the July issue of the Journal of Ethnopharmacology.
Researchers administered oral THC to one individual; analogous field studies were performed on three separate subjects before and after smoking cannabis. All four subjects were field-tested for night vision with a Scotopic Sensitivity Tester-1. "In both test situations, improvements in night vision measures were noted after THC or cannabis," authors found.
"The current study supports the previous ethnobotanical observations that cannabis may improve night vision," they concluded. "This effect seems to be dose-dependent and cannabinoid-mediated. Further study may reveal whether this clinical application of cannabis could be added to treatment of pain, spasticity of multiple sclerosis, and nausea of chemotherapy as recognized indications for this ancient substance."
For more information, please contact Allen St. Pierre or Paul Armentano of the NORML Foundation at (202) 483-5500. Abstracts of the study are available at: http://www.sciencedirect.com/science/journal/03788741
Missoula, MT: Administration of cannabis improves night vision in a dose-dependent manner, according to the findings of a case study to be published in the July issue of the Journal of Ethnopharmacology.
Researchers administered oral THC to one individual; analogous field studies were performed on three separate subjects before and after smoking cannabis. All four subjects were field-tested for night vision with a Scotopic Sensitivity Tester-1. "In both test situations, improvements in night vision measures were noted after THC or cannabis," authors found.
"The current study supports the previous ethnobotanical observations that cannabis may improve night vision," they concluded. "This effect seems to be dose-dependent and cannabinoid-mediated. Further study may reveal whether this clinical application of cannabis could be added to treatment of pain, spasticity of multiple sclerosis, and nausea of chemotherapy as recognized indications for this ancient substance."
For more information, please contact Allen St. Pierre or Paul Armentano of the NORML Foundation at (202) 483-5500. Abstracts of the study are available at: http://www.sciencedirect.com/science/journal/03788741
[Serum testosterone concentrations in cannabis and opiate users]
[Article in German]
Friedrich G, Nepita W, Andre T.
Institut fur Rechtsmedizin, Universitat Freiburg.
The object of this study was to establish possible influences of long-term cannabis usage on plasma testosterone levels. The plasma testosterone levels of 66 male Pakistani who for years had smoked cannabis daily or drank cannabis regularly where measured after chronic and acute intake of the drug and compared with a material of 41 normal controls, i.e. persons who did not use cannabis. An evaluation of the results showed that there were no significant differences between the two groups. No influence of long-term cannabis usage on plasma testosterone levels was found. Furthermore we wished to find out wether long-term heroin abuse showed an effect on plasma testosterone levels. The concentrations of testosterone in the plasma of 102 heroin addicts assigned to a Methadone Program were measured and compared with the values of 29 male healthy students as controls. Plasma testosterone levels were found to be significantly decreased in heroin addicts as compared to controls.
PMID: 2241844 [PubMed - indexed for MEDLINE]
[Article in German]
Friedrich G, Nepita W, Andre T.
Institut fur Rechtsmedizin, Universitat Freiburg.
The object of this study was to establish possible influences of long-term cannabis usage on plasma testosterone levels. The plasma testosterone levels of 66 male Pakistani who for years had smoked cannabis daily or drank cannabis regularly where measured after chronic and acute intake of the drug and compared with a material of 41 normal controls, i.e. persons who did not use cannabis. An evaluation of the results showed that there were no significant differences between the two groups. No influence of long-term cannabis usage on plasma testosterone levels was found. Furthermore we wished to find out wether long-term heroin abuse showed an effect on plasma testosterone levels. The concentrations of testosterone in the plasma of 102 heroin addicts assigned to a Methadone Program were measured and compared with the values of 29 male healthy students as controls. Plasma testosterone levels were found to be significantly decreased in heroin addicts as compared to controls.
PMID: 2241844 [PubMed - indexed for MEDLINE]
THOSE are some studies i can find quickly, i have the article on where it proves that weed has no eeffect on estrogen
i also have another study proving that weed does NOT cause lung caner.
to all his own, now would i be bigger w/o weed? Probably just a little, BUT WOULD I EAT AS MUCH WHILE BULKING? probbably not
Jkurz, depending on who u want to listen to, if you can find me a study that was done on HUMANS, not mice, that can prove
1. Weed rasies estrogen levels
2. Weed raises cortisol
3. Weed lowers testosterone
and ill show u a study that proves the opposite, its all about who payed for the testing/study.
Like i said to each thier own/moderation, but out of curiosity Jkurz have u ever been a chronic smoker then quit, and got better gains in the GYM? If so then ill believe YOU way more then any study.
my .02
Thaks jkurz, nice points too!
i also have another study proving that weed does NOT cause lung caner.
to all his own, now would i be bigger w/o weed? Probably just a little, BUT WOULD I EAT AS MUCH WHILE BULKING? probbably not
Jkurz, depending on who u want to listen to, if you can find me a study that was done on HUMANS, not mice, that can prove
1. Weed rasies estrogen levels
2. Weed raises cortisol
3. Weed lowers testosterone
and ill show u a study that proves the opposite, its all about who payed for the testing/study.
Like i said to each thier own/moderation, but out of curiosity Jkurz have u ever been a chronic smoker then quit, and got better gains in the GYM? If so then ill believe YOU way more then any study.
my .02
Thaks jkurz, nice points too!
JKurz1
Banned
Hey bro..Im not gonna get into a pissing contest....I truly could care less....Ive tried it here and there to get my appetite up and it's only made me tired...then I end up waking up every hoour.....just not for me....actually, I just smoked a few days again cause I needed some cals in, but it had the opposite effect...dextropse works much better
So, do what you want. Hell, if it works for you, go for it......I use vicodine every few days to help with back pain and soreness, and I'm pretty sure I'm addicted....even though I take MAYBE 1 tab every few days, its under control, but still there....with me?
So, do what you want. Hell, if it works for you, go for it......I use vicodine every few days to help with back pain and soreness, and I'm pretty sure I'm addicted....even though I take MAYBE 1 tab every few days, its under control, but still there....with me?
JKurz1 said:
hey no pissing contest, i like debates =], might learn something new i didnt know.
Now hey, u tried it so i cant knock u and tell u "your wrong mofo". Its crazy i know alot of good people that weed kills thier appetite too, so it really looks like no benefit for you.
DEF know im addicted to BUD, but not addicted to where i cant stop, i just dont want to right now. Ive kicked bud plenty of times in the past where i needed to be clean and what not but when those plans fell through i started smokin again. Ill def quit in time, im only 20 right now, so i have time to learn from my mistakes. Ill def slow my weed consuption as i get older. And if i want to ill kick it.
I know what u mean tho Jkurz, it was a good debate. I just wanted to get the point accrss that if u have a study for one thing, theres always something to disprove that, it sucks because it leaves us to try for ourselves lol
*Bunny* said:Just wanted to say I KNEW I'd find you in here after seeing the title of this thread ... lol
lmao, something dont change huh bunns lol
im actually quite interested to see the answers from people who chronically smoked during BB. and then stoped, and see if thier answers would shed a possitive/negative ligght on weed.
u know i love you bunz! lol and one day i will quit for you! =]
Back away from the bud what kind of bars? =]
lol honestly ive had to quit plenty,
Probation - when i was a kid
Sanitation - Couple yrs ago went 6months.
i mean, i would take that bet if i wanted to quit, or needed some food lol
but ill take u up on that in the future, then ill be able to make up my mind if weed is beneficial to MYSELF.
Thanks for the poositive push jkurs, i know its just a vice and i will eventually.
lol honestly ive had to quit plenty,
Probation - when i was a kid
Sanitation - Couple yrs ago went 6months.
i mean, i would take that bet if i wanted to quit, or needed some food lol
but ill take u up on that in the future, then ill be able to make up my mind if weed is beneficial to MYSELF.
Thanks for the poositive push jkurs, i know its just a vice and i will eventually.
Lifterforlife
New member
I would just ask one simple question...has it helped you? If it has, more power to you. I know plenty of folks who can's smoke it because they get all crazy paranoid. Others get mellow and "see the world". I think(in my experience, over long term use is where the negatives come in as far as paranoia, thinking everyone is looking at you and talking about you, etc.) This is totally discounting the physical side of things.
This in the end is the bottom line I guess....folks are going to do what they want to do, that is what free will is all about.
This in the end is the bottom line I guess....folks are going to do what they want to do, that is what free will is all about.
macrophage69alpha
New member
cannabis induced psychosis. (actually know someone that this occured to, they had a full psychotic break--- note this is extremely uncommon less than 1/1000)
Neuropsychopharmacology. 2004 Aug;29(8):1558-72. Links
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis.D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH.
Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. [email protected]
Recent advances in the understanding of brain cannabinoid receptor function have renewed interest in the association between cannabinoid compounds and psychosis. In a 3-day, double-blind, randomized, and counterbalanced study, the behavioral, cognitive, and endocrine effects of 0, 2.5, and 5 mg intravenous delta-9-tetrahydrocannabinol (Delta-9-THC) were characterized in 22 healthy individuals, who had been exposed to cannabis but had never been diagnosed with a cannabis abuse disorder. Prospective safety data at 1, 3, and 6 months poststudy was also collected. Delta-9-THC (1) produced schizophrenia-like positive and negative symptoms; (2) altered perception; (3) increased anxiety; (4) produced euphoria; (5) disrupted immediate and delayed word recall, sparing recognition recall; (6) impaired performance on tests of distractibility, verbal fluency, and working memory (7) did not impair orientation; (8) increased plasma cortisol. These data indicate that Delta-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses. These data warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
cannabis does impact prolactin levels, transiently. It has been linked with gynecomastia.
this study abrogates the findings that THC and other cannaboids are not ER agonists/antagonists (since there are other components in marijuana)
Estrogenic effects of marijuana smoke condensate and cannabinoid compounds.Lee SY, Oh SM, Chung KH.
National Institute of Scientific Investigation, 331-1 Shinwol-7-dong, Yangcheon-gu, Seoul 158-707, Korea; Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Korea.
Chronic exposure to marijuana produces adverse effects on the endocrine and reproductive systems in humans; however, the experimental evidence for this presented thus far has not been without controversy. In this study, the estrogenic effect of marijuana smoke condensate (MSC) was evaluated using in vitro bioassays, viz., the cell proliferation assay, the reporter gene assay, and the ER competitive binding assay. The results of these assays were compared with those of three major cannabinoids, i.e., THC, CBD, and CBN. The estrogenic effect of MSC was further confirmed by the immature female rat uterotrophic assay. MSC stimulated the estrogenicity related to the ER-mediated pathway, while neither THC, CBD, nor CBN did. Moreover, treatment with 10 and 25 mg/kg MSC induced significant uterine response, and 10 mg/kg MSC resulted in an obvious change in the uterine epithelial cell appearance. MSC also enhanced the IGFBP-1 gene expression in a dose-dependent manner. To identify the constituents of MSC responsible for its estrogenicity, the MSC fractionated samples were examined using another cell proliferation assay, and the estrogenic active fraction was analyzed using GC-MS. In the organic acid fraction that showed the strongest estrogenic activity among the seven fractions of MSC, phenols were identified. Our results suggest that marijuana abuse is considered an endocrine-disrupting factor. Furthermore, these results suggest that the phenolic compounds contained in MSC play a role in its estrogenic effect.
Neuropsychopharmacology. 2004 Aug;29(8):1558-72. Links
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis.D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH.
Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. [email protected]
Recent advances in the understanding of brain cannabinoid receptor function have renewed interest in the association between cannabinoid compounds and psychosis. In a 3-day, double-blind, randomized, and counterbalanced study, the behavioral, cognitive, and endocrine effects of 0, 2.5, and 5 mg intravenous delta-9-tetrahydrocannabinol (Delta-9-THC) were characterized in 22 healthy individuals, who had been exposed to cannabis but had never been diagnosed with a cannabis abuse disorder. Prospective safety data at 1, 3, and 6 months poststudy was also collected. Delta-9-THC (1) produced schizophrenia-like positive and negative symptoms; (2) altered perception; (3) increased anxiety; (4) produced euphoria; (5) disrupted immediate and delayed word recall, sparing recognition recall; (6) impaired performance on tests of distractibility, verbal fluency, and working memory (7) did not impair orientation; (8) increased plasma cortisol. These data indicate that Delta-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses. These data warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
cannabis does impact prolactin levels, transiently. It has been linked with gynecomastia.
this study abrogates the findings that THC and other cannaboids are not ER agonists/antagonists (since there are other components in marijuana)
Estrogenic effects of marijuana smoke condensate and cannabinoid compounds.Lee SY, Oh SM, Chung KH.
National Institute of Scientific Investigation, 331-1 Shinwol-7-dong, Yangcheon-gu, Seoul 158-707, Korea; Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Korea.
Chronic exposure to marijuana produces adverse effects on the endocrine and reproductive systems in humans; however, the experimental evidence for this presented thus far has not been without controversy. In this study, the estrogenic effect of marijuana smoke condensate (MSC) was evaluated using in vitro bioassays, viz., the cell proliferation assay, the reporter gene assay, and the ER competitive binding assay. The results of these assays were compared with those of three major cannabinoids, i.e., THC, CBD, and CBN. The estrogenic effect of MSC was further confirmed by the immature female rat uterotrophic assay. MSC stimulated the estrogenicity related to the ER-mediated pathway, while neither THC, CBD, nor CBN did. Moreover, treatment with 10 and 25 mg/kg MSC induced significant uterine response, and 10 mg/kg MSC resulted in an obvious change in the uterine epithelial cell appearance. MSC also enhanced the IGFBP-1 gene expression in a dose-dependent manner. To identify the constituents of MSC responsible for its estrogenicity, the MSC fractionated samples were examined using another cell proliferation assay, and the estrogenic active fraction was analyzed using GC-MS. In the organic acid fraction that showed the strongest estrogenic activity among the seven fractions of MSC, phenols were identified. Our results suggest that marijuana abuse is considered an endocrine-disrupting factor. Furthermore, these results suggest that the phenolic compounds contained in MSC play a role in its estrogenic effect.
pitbullrocco
New member
been smoking ED for almost 10 years (at least 6 j's/day).....quit a couple times for jobs, etc.....not longer than a couple months.....only thing i noticed was my body was less drowsy and lethargic.....harder to fall sleep (& more money in my pocket)....rebound effect i guess.....i also became an angrier human being......more tense and irritable.....i ate less and lost weight
chemically, i think it would be easier to shed adipose while not smoking (or at least not every day almost nonstop).....seems like i did see a study once that showed subjects actually lost weight while toking up.....i think it was in japan
i was thinking of quitting this week during my bulk, b/c i don't like the fact that cort levels spike = catabolic......
chemically, i think it would be easier to shed adipose while not smoking (or at least not every day almost nonstop).....seems like i did see a study once that showed subjects actually lost weight while toking up.....i think it was in japan
i was thinking of quitting this week during my bulk, b/c i don't like the fact that cort levels spike = catabolic......
I smoke everyday, a little less than i use to... on the normal.. 2-3 cigarillos a day... now.. more like once a day... weekends tend to get the higher numbers.
My body has actually gotten more fit since i started... given i dont know the effects w/o it and how my lifestyle has changed since then...
but i know my body... and i know it doesnt effect me enough to change...
BTW i used to smoke cigs as well and cut that ... now just some black and mild *milds every week
Do what feels right... if weed is one thing that might fullfill that then let it be.
shit... i have a six pack now, and when i didnt smoke i was BIgger but about 15-20 lbs overweight.
My body has actually gotten more fit since i started... given i dont know the effects w/o it and how my lifestyle has changed since then...
but i know my body... and i know it doesnt effect me enough to change...
BTW i used to smoke cigs as well and cut that ... now just some black and mild *milds every week
Do what feels right... if weed is one thing that might fullfill that then let it be.
shit... i have a six pack now, and when i didnt smoke i was BIgger but about 15-20 lbs overweight.
nodiggitydave
New member
awesome thread
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