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napsgear
genezapharmateuticals
domestic-supply
puritysourcelabs
Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

SesaPURE (formerly Sesamax) For Fat Loss and Cholesterol Levels

Re: Sesamax For Fat Loss and Cholesterol Levels

One Cardio Breeze and 2 Sesamax this AM. I feel pretty "cheery" but not really bouncing off the walls, which I like a lot...but then it is Friday and casual day.
 
Re: Sesamax For Fat Loss and Cholesterol Levels

I have a question about sesamax's properties of helping the liver breakdown alcohol by increasing certain enzymes. In the product description it says:

" Sesamin and episesamin have been shown to raise aldehyde dehydrogenase levels by more than 3 fold. When alcohol is consumed, it enters cells and is broken down into a toxic compound known as acetaldehyde. An enzyme called aldehyde dehydrogenase 2 (ALDH2) converts the acetaldehyde into acetic acid, which is non-toxic and can be readily used by your body to provide energy."

Now if I'm reading correctly it says ALDH is raised more than 3 fold. ALDH is the enzyme which as a first step breaks down alcohol into acetaldehyde (which is actually even more toxic than alcohol itself I have read elsewhere). Then the second step is breaking down the acetaldehyde with the enzyme ALDH2. It isn't mentioned that the ALDH2 levels are increased by using sesamin. So I'm worried, if ALDH2 is not increased, than that would mean alcohol is first broken down faster/better into acetaldehyde due to the larger amount of ALDH enzyme available. But now the second step goes just as fast as before supplementing sesamin due to unchanged amount of ALDH2, so the level of (the more toxic) acetaldehyde will stay higher for longer in the body. Can you clear this up Ulter?
 
Re: Sesamax For Fat Loss and Cholesterol Levels

No, but Macro will. He knows more about alcohol because I don't drink.
 
Re: Sesamax For Fat Loss and Cholesterol Levels

Ulter said:
No, but Macro will. He knows more about alcohol because I don't drink.

Okay, would be nice if he could comment.

I searched on Pubmed and after reading this maybe I understand it better. The first step is done by alcohol dehydrogenase, the second step by aldehyde dehydrogenase. So with the 3 fold increase in aldehyde dehydrogenase occuring from sesamin supplementation, it would mean first step goes just as fast/good as without sesamin, but second step goes faster/better.

Antioxidative roles of sesamin, a functional lignan in sesame seed, and it's effect on lipid- and alcohol-metabolism in the liver: a DNA microarray study.

Kiso Y.

Institute for Health Care Science, Suntory Ltd., 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan. [email protected]

Sesamin was orally administered to rats, and blood, bile and urine were collected periodically. Over 40% of the dose of sesamin was detected in bile as glucuronides of 2-(3, 4-methylenedioxyphenyl)-6-(3, 4-dihydroxyphenyl)-cis-dioxabicyclo[3.3.0] octane and 2-(3, 4-dihydroxyphenyl)-6-(3, 4-dihydroxyphenyl)-cis-dioxabicyclo[3.3.0] octane by 24 hr after administration. Antioxidant activities of these metabolites were compared and catechol metabolites showed strong radical scavenging activities against not only superoxide anion radical but also hydroxyl radical. It was suggested that sesamin was absorbed by the route of portal vein and metabolized to mono- or di-catechol metabolite by drug metabolizing enzymes in the liver cells. Both metabolites exhibited antioxidant activity in the liver and were finally conjugated with glucuronic acid and to excrete in bile. Sesamin can be classified as a pro-antioxidant. The profiles of gene expression of the liver in rats given sesamin or vehicle were compared. The gene expression levels of the late stage enzymes of beta-oxidation including trifunctional enzyme, acyl-CoA oxidase, bifunctional enzyme and 3-ketoacyl-CoA thiolase were significantly increased by sesamin. On the other hand, the transcription of the genes encoding the enzymes for fatty acid synthesis was decreased. Moreover, in sesamin rats, the gene expression of aldehyde dehydrogenase was increased about 3-fold, whereas alcohol dehydrogenase, liver catalase and CYP2E1 were not changed. These results suggested that sesamin ingestion regulated the transcription levels of hepatic metabolizing enzymes for lipids and alcohol.

PMID: 15630196 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=15630196&query_hl=1
 
Re: Sesamax For Fat Loss and Cholesterol Levels

By the way, why is the shipping for 1 bottle of Sesamax so fucking high?! I live in europe but wanted to order from the US store since it's so much cheaper than in the EU store. But cheapest shipping is more than 50 dollars, lol. Other american companies I order from charge 8 to 12 dollars.

Ordering from the EU store is 39 dollars... then competitors (Scivation Sesamin) just are too favourable compared to Scot's finest. As much as I would like to support you, I have my budget and that would be a too big of a price difference.

I actually don't understand why there even is an EU store. What would people prefer.... buy from american store for cheaper, pay reasonable shipping and probably no taxes, or very slight chance customs makes you pay when you order big.....or buy from EU store and pay a higher price for sure in which you pay taxes and the shipping cost is pretty much the same ($12) as what other amercian companies charge to ship from america to the eu.
 
Re: Sesamax For Fat Loss and Cholesterol Levels

Most of this has been answered at least 20 or 30 times on this board because other people like yourself don't take all factors into account. I'll just give you the highlights.

Shipping prices from the US to EU are not set by the store just like none of the other shipping prices are set by the store. Those numbers come directly from FedEx and are inserted into the shipping charge.

Other stores will mail your products to you. Since a large number of these shipments are lost you stand a chance of never getting your package through the mail. We tried it 4 years ago. Never again. If we ship it, you'll get it without fail because we have tracking. You can't track mail from one country to the next. So it's cheaper, but no thanks.

In case you haven't looked in the stores lately, imported goods cost more than they do in the country of origin. We have to get it to Europe, pay the taxes and have someone ship it to you from England. So of course it's going to cost more there just like everything else does.

You can pray that customs won't charge you but that's not very likely. You can also pray that you get your product even if you agreed to pay. Most of the products in the AF Store are not allowed in the EU. So you stand a very good chance of losing it to seizure. This alone makes the AF Euro Store a good idea.

Tell me who's selling the same grade sesamin lingnan's as The AF Store for the same money. In fact, tell me who has even a lower grade for the same money. You brought up Scivation. They sell 90 500mg capsules for $29 at bb.com. Sesamax is 120 700mg capsules for the same price. Where's your deal? I won't even get into the difference in quality.

That's enough for now. :)
 
Re: Sesamax For Fat Loss and Cholesterol Levels

Ulter said:
Most of this has been answered at least 20 or 30 times on this board because other people like yourself don't take all factors into account. I'll just give you the highlights.

Shipping prices from the US to EU are not set by the store just like none of the other shipping prices are set by the store. Those numbers come directly from FedEx and are inserted into the shipping charge.

Other stores will mail your products to you. Since a large number of these shipments are lost you stand a chance of never getting your package through the mail. We tried it 4 years ago. Never again. If we ship it, you'll get it without fail because we have tracking. You can't track mail from one country to the next. So it's cheaper, but no thanks.

In case you haven't looked in the stores lately, imported goods cost more than they do in the country of origin. We have to get it to Europe, pay the taxes and have someone ship it to you from England. So of course it's going to cost more there just like everything else does.

You can pray that customs won't charge you but that's not very likely. You can also pray that you get your product even if you agreed to pay. Most of the products in the AF Store are not allowed in the EU. So you stand a very good chance of losing it to seizure. This alone makes the AF Euro Store a good idea.

Tell me who's selling the same grade sesamin lingnan's as The AF Store for the same money. In fact, tell me who has even a lower grade for the same money. You brought up Scivation. They sell 90 500mg capsules for $29 at bb.com. Sesamax is 120 700mg capsules for the same price. Where's your deal? I won't even get into the difference in quality.

That's enough for now. :)

I'm sorry i didn't read the other 20 to 30 times :), thanks for explaining.

Still I don't understand. Bodybuilding.com charges me 9 dollars if I order 1 bottle like sesamin. In all the orders, about 30 I think, I only paid taxes twice...you're allowed to import to a certain amount of $ without paying taxes, and even if it's above that they don't even check often unless it's a very big order.

From your site it says at Sesamax info: 120 caps of 420 mg sesamin...not 700? Still 120 times 420mg would be better than 90 times 500, but not when I can get the Scivation for 29+9=38 and the sesamax for 39+12=51.
But why is Scivation's version of lesser quality, what makes you say that?

I'll buy yours if you can convince me :)
 
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Re: Sesamax For Fat Loss and Cholesterol Levels

You need to read those labels a little closer. Theirs is 500mg of standardized Sesamax is 420mg of EPISESAMIN which equals 700mg of standardized. Neither bb.com of anyone else ships FedEx to the EU for $9. Their minimum is $30 and that's for a letter not a box. Theirs is 45 grams and Sesamax is 84 grams. It's up to you.
 
Re: Sesamax For Fat Loss and Cholesterol Levels

Okay, well, I'll buy at the EU store and support you guys and indirectly the board.

I still think you really should offer better shipping options though :chomp:
 
Re: Sesamax For Fat Loss and Cholesterol Levels

Ulter said:
You can pray that customs won't charge you but that's not very likely. You can also pray that you get your product even if you agreed to pay. Most of the products in the AF Store are not allowed in the EU. So you stand a very good chance of losing it to seizure. This alone makes the AF Euro Store a good idea.

Nope, not a good idea. It's a FANTASTIC idea! Here in Austria, everything from the US (or other non-EU countries) gets opened and hit with crazy duties. The cutoff for duty-free imports is only €22 (approx. $25), which is next to nothing. And like Ulter said, even if duties weren't an issue, I'm sure I wouldn't be able to import those products anyway. As an example, many years ago I ordered some vitamin C from the US. It had to be sent back (!!!) because I would have needed official permission from the Health Ministry to import it. So there's nooooo way they'd let me import all the Glucorell, Tylers and Sesamax that I'm constantly ordering from the AF Euro shop. One thing I always wonder - why is it possible to import just about anything into the UK (which IS an EU country) from the US but not to the Continent...? Must be some sort of gentlemen's agreement left over from colonial times :)

Yes, the shipping prices from the AF Euro shop are not cheap, but they're a fixed fee. So if you place a larger order, it turns out to be a pretty good deal.
 
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