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Ulter said:No, but Macro will. He knows more about alcohol because I don't drink.
Antioxidative roles of sesamin, a functional lignan in sesame seed, and it's effect on lipid- and alcohol-metabolism in the liver: a DNA microarray study.
Kiso Y.
Institute for Health Care Science, Suntory Ltd., 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan. [email protected]
Sesamin was orally administered to rats, and blood, bile and urine were collected periodically. Over 40% of the dose of sesamin was detected in bile as glucuronides of 2-(3, 4-methylenedioxyphenyl)-6-(3, 4-dihydroxyphenyl)-cis-dioxabicyclo[3.3.0] octane and 2-(3, 4-dihydroxyphenyl)-6-(3, 4-dihydroxyphenyl)-cis-dioxabicyclo[3.3.0] octane by 24 hr after administration. Antioxidant activities of these metabolites were compared and catechol metabolites showed strong radical scavenging activities against not only superoxide anion radical but also hydroxyl radical. It was suggested that sesamin was absorbed by the route of portal vein and metabolized to mono- or di-catechol metabolite by drug metabolizing enzymes in the liver cells. Both metabolites exhibited antioxidant activity in the liver and were finally conjugated with glucuronic acid and to excrete in bile. Sesamin can be classified as a pro-antioxidant. The profiles of gene expression of the liver in rats given sesamin or vehicle were compared. The gene expression levels of the late stage enzymes of beta-oxidation including trifunctional enzyme, acyl-CoA oxidase, bifunctional enzyme and 3-ketoacyl-CoA thiolase were significantly increased by sesamin. On the other hand, the transcription of the genes encoding the enzymes for fatty acid synthesis was decreased. Moreover, in sesamin rats, the gene expression of aldehyde dehydrogenase was increased about 3-fold, whereas alcohol dehydrogenase, liver catalase and CYP2E1 were not changed. These results suggested that sesamin ingestion regulated the transcription levels of hepatic metabolizing enzymes for lipids and alcohol.
PMID: 15630196 [PubMed - indexed for MEDLINE]
Ulter said:Most of this has been answered at least 20 or 30 times on this board because other people like yourself don't take all factors into account. I'll just give you the highlights.
Shipping prices from the US to EU are not set by the store just like none of the other shipping prices are set by the store. Those numbers come directly from FedEx and are inserted into the shipping charge.
Other stores will mail your products to you. Since a large number of these shipments are lost you stand a chance of never getting your package through the mail. We tried it 4 years ago. Never again. If we ship it, you'll get it without fail because we have tracking. You can't track mail from one country to the next. So it's cheaper, but no thanks.
In case you haven't looked in the stores lately, imported goods cost more than they do in the country of origin. We have to get it to Europe, pay the taxes and have someone ship it to you from England. So of course it's going to cost more there just like everything else does.
You can pray that customs won't charge you but that's not very likely. You can also pray that you get your product even if you agreed to pay. Most of the products in the AF Store are not allowed in the EU. So you stand a very good chance of losing it to seizure. This alone makes the AF Euro Store a good idea.
Tell me who's selling the same grade sesamin lingnan's as The AF Store for the same money. In fact, tell me who has even a lower grade for the same money. You brought up Scivation. They sell 90 500mg capsules for $29 at bb.com. Sesamax is 120 700mg capsules for the same price. Where's your deal? I won't even get into the difference in quality.
That's enough for now.
Ulter said:You can pray that customs won't charge you but that's not very likely. You can also pray that you get your product even if you agreed to pay. Most of the products in the AF Store are not allowed in the EU. So you stand a very good chance of losing it to seizure. This alone makes the AF Euro Store a good idea.