I am curious what literature people are reading that makes them think lymphatic absorption will be so much better with a THP ether than an undecanoate ester (which suck, orally, BTW).
Basically all of the studies are by the Japanese pharmaceutical company whose product it was. They use a methoxycyclopentane ether, not a THP ether -- and they have some strange methodology, such as delivering the drug into the small intestine to test an oral. And, there is a study that makes their reason for having done so seem suspect -- I will quote from the study:
"The lymphatic absorption from the small intestine was very small in the absence of bile compared with that when bile was present. The lymphatic absorption was greatest when drug was administered to the upper small intestine with bile, was smaller for the lower regions of the small intestine, and was negligible for the stomach and the large intestine. "
Another thing I am curious about -- the androgen that does make it to the blood is encased within chylomicrons and VLDL's -- don't these get metabolized in the liver?? If so, is there anything to suggest that the androgen is freed before this happens??
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