I personally prefer Primo over EQ. However, I believe both impact Estrogen with Primo reducing (or perhaps binding to E2) and with EQ, converting estrogen to Estradiol (this has been reflected in my bloodwork running both compounds). Thus, you may want to consider this (and ALWAYS get bloodwork) and adjust Testosterone base to ensure adequate E2 levels or risk drying out your joints and potentially impacting cardiovascular health more than necessary.