Oxytocin .... Intense orgasms!!!

[John Juan]

Does it make you feel happy during the day? Like in a good mood?

I notice my dreams are so real I want to keep sleeping and dreaming. I'm just getting over a month long walking pneumonia bug so yesterday and today are the first two days I woke up happy. I feel great now at work but I don't notice it being from the oxytocin. I just notice incredibly vivid dreams and I sometimes talk in my sleep because it seems so real.

Last night I dreamed I was playing with my favorite cat I had in high school. I miss that cat!

 

[wootoom]

Is this drug just about dreams?

 

[John Juan]

Is this drug just about dreams?

No. It's has a huge impact on erections and sex. There are lots of receptors for oxytocin present in the penis, particularly in the corpus cavernosa, the long tubes that fill with blood during an erection. Here is a study:

Oxytocin injected into the ventral subiculum or the posteromedial cortical nucleus of the amygdala induces penile erection and increases extracellular dopamine levels in the nucleus accumbens of male rats.

AuthorsMelis MR, et al. Show all Journal
Eur J Neurosci. 2009 Oct;30(7):1349-57. doi: 10.1111/j.1460-9568.2009.06912.x. Epub 2009 Sep 21.

Affiliation
Abstract
Oxytocin (20-100 ng) was found to be able to induce penile erection when injected unilaterally into the ventral subiculum or the posteromedial cortical nucleus of the amygdala of male rats. The pro-erectile effect started mostly 30 min after treatment and was abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (1-2 microg), an oxytocin receptor antagonist, into the ventral subiculum or posteromedial cortical nucleus. Oxytocin-induced penile erection occurred 15 min after the increase in the concentration of extracellular dopamine and its metabolite 3,4-dihydroxyphenylacetic acid in the dialysate obtained from the nucleus accumbens, which was also abolished by d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin. The pro-erectile effect of oxytocin was also reduced by cis-flupentixol (2 and 5 microg), a dopamine receptor antagonist, injected into the nucleus accumbens, and by (+)MK-801 (5 microg), a noncompetitive N-methyl-d-aspartate receptor antagonist, injected into the ventral tegmental area, but not into the nucleus accumbens. Together with studies showing that glutamatergic efferents from the ventral subiculum/posteromedial cortical nucleus of the amygdala to other areas of the limbic system modulate the activity of mesolimbic dopaminergic neurons, these findings suggest that oxytocin injected into these areas increases glutamatergic neurotransmission in the ventral tegmental area. This, in turn, activates mesolimbic dopaminergic neurons, leading to penile erection. These results provide evidence that the ventral subiculum and the posteromedial cortical nucleus of the amygdala participate in a neural circuit that controls not only the consummatory aspects of sexual behaviour (e.g. penile erection and copulatory performance), but also its motivational/reward aspects, confirming a key role of oxytocin and dopamine in these processes.

 

[John Juan]

The acute effects of intranasal oxytocin administration on endocrine and sexual function in males.

AuthorsBurri A, et al. Show all Journal
Psychoneuroendocrinology. 2008 Jun;33(5):591-600. doi: 10.1016/j.psyneuen.2008.01.014. Epub 2008 Mar 28.

Affiliation
Abstract
The role of the neuropeptide oxytocin (OT) ranges from the modulation of neuroendocrine physiological effects to the establishment of complex social and bonding behaviours. Experimental studies in animals, as well as case reports in humans, suggest that OT affects different aspects of sexual behaviour and has predominantly facilitating properties for sexual appetence and performance. Using a previously established experimental paradigm of sexual arousal and masturbation-induced orgasm, this study investigated the acute effects of intranasal OT application (24I.U.) on endocrine parameters and measures of sexual appetence and function in healthy men (n=10). In a double-blind, placebo-controlled, balanced cross-over design, sexual arousal, and orgasm were induced by an erotic film and masturbation. In addition to the continuous recording of endocrine (OT, cortisol, prolactin, epinephrine, norepinephrine) and cardiovascular data (heart rate), parameters of appetitive, consummatory, and refractory sexual behaviour were assessed using the acute sexual experience scale (ASES). OT plasma levels were significantly elevated after intranasal OT throughout the whole experiment (>60 min). In addition, OT treatment induced significantly higher increases in epinephrine plasma levels during sexual activity without affecting cortisol levels, prolactin levels or heart rate. OT treatment did not alter appetitive, consummatory, and refractory sexual behaviour according to the ASES. However, when subjects were asked about their subjective perception of whether OT or placebo had been applied, eight out of 10 subjects in the OT group answered correctly, thus pointing to an altered perception of arousal. In conclusion, intranasally administered OT leads to a marked increase in OT plasma levels together with increased secretion of catecholamines when subjects are engaged in sexual activity in a laboratory setting. As the effects of OT on sexual behaviour were equivocal, future studies should examine possible facilitating effects further by including males, females, and couples in a field setting, taking into account that OT exerts the most prominent behavioural effects in pair bond formations.

 

[wootoom]

Well I jerk off 5 time a a day and service the old lady once...I might not need it LOLOLOL

 

[John Juan]

Well I jerk off 5 time a a day and service the old lady once...I might not need it LOLOLOL

Bahahahaha Good Lord Almighty!!! :

 

[testionate]

It's still only 2units to get 20mcg even if you have a 30unit diabetic syringe

Got my order and ready to try it for the first time here. Just want to be certain of the dosage. You're saying just two tick marks on my 30 unit insulin syringe? Doesn't seem like much. BTW, thanks for the info and the thread!

 

[mustang_00]

Is this drug just about dreams?

it's the martin luther king of drugs!!

 

[mustang_00]

is the half life really a few minutes up to 15min??? i've heard a few stories that this stuff is used to induce labor (it's used for A LOT of things actually) but, has to be re administered every 15-20 minutes, and thats using higher doses... it only makes sense that for social anxiety/interactions. or, even using for sex it would have to be injected again. on the plus side. if that half life is true. it would kick in pretty damn fast, right?

no one really talks about the dose that is used, and for what reason on here. just mention dreams. it's not just you guys, other boards do it too.
kinda sounds like you're injecting the feeling you get after you rub one out, and you're just relaxed for a few and that's it.

pretty crazy that it's used for abortion. is that just for a comfort/bonding feeling to help the person mentally cope. or does it actually aid in skilliting of the fetus process?

i have so many questions about it's effects with gyno and tren lactation hahaha

 

[John Juan]

Got my order and ready to try it for the first time here. Just want to be certain of the dosage. You're saying just two tick marks on my 30 unit insulin syringe? Doesn't seem like much. BTW, thanks for the info and the thread!

It's barely anything, less than a drop. 20mcg out of a 10mg vial means there are 500 doses in the vial.