Need advice on presciption for anti-anxiety

[Slyder190]

I've used both (tried em recreationally) and Klon's mellow me out as where Xanax puts me to sleep.

 

[nuevo laredo]

Now - Klonapin has the longest 1/2 life of all the Benzo's which makes it the choice script cause it takes a little while to "slowly" kick-in (which makes it a better choice than Val, or Xan) with Valium or Xanax - the relief is quick - which makes them more mentally satisfying as a "quick-fix" - however - with the shorter 1/2-life - you need to take them more often then the Klon.

Klonopin most definitley has a longer half-life than Xanax but are you sure that it has a longer half-life than Valium? Can you cite any references?

 

[itlnstln]

Klonopin most definitley has a longer half-life than Xanax but are you sure that it has a longer half-life than Valium? Can you cite any references?

********
Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%. Maximum plasma concentrations of clonazepam are reached within 1 to 4 hours after oral administration. Clonazepam is approximately 85% bound to plasma proteins. Clonazepam is highly metabolized, with less than 2% unchanged clonazepam being excreted in the urine. Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated, and glucuronidated. Cytochrome P-450, including CYP3A, may play an important role in clonazepam reduction and oxidation. The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmacokinetics are dose-independent throughout the dosing range. There is no evidence that clonazepam induces its own metabolism or that of other drugs in humans.*************


++++++++++
Diazepam is a benzodiazepine with CNS depressant properties and a somewhat flatter dose-response slope than the sedative-hypnotic drugs. In laboratory animals, it produces, in varying doses, taming, disinhibitory, sedative, anticonvulsant, muscle relaxant, ataxic and hypnotic effects.

Diazepam is relatively devoid of autonomic effects and does not significantly reduce locomotor activity at low doses, or depress amphetamine-induced excitation. In high doses, it activates the drug metabolizing enzymes in the liver. Diazepam also possesses dependence liability and may produce withdrawal symptoms, but has a wide margin of safety against poisoning.

Metabolism studies in animals and man have indicated that oral diazepam is rapidly absorbed from the gastrointestinal tract. Peak blood levels are reached within 1-2 hours after administration. The acute half-life is 6-8 hours with a slower decline thereafter, possibly due to tissue storage.

In humans, comparable blood levels of diazepam were obtained in maternal and cord blood indicating placental transfer of the drug. Diazepam may appear in human breast milk.

With the parenteral form, peak blood levels are reached within 15 minutes after i.v. administration and are of the same magnitude as after oral administration. The respective half-life is approximately 2-3 hours.

The distribution and fate of tritium-labeled diazepam in man has indicated that the drug has a rapid and extensive uptake by tissues. Although the radioactivity in the blood appears to represent mainly the intact drug, diazepam was shown to be excreted exclusively in the form of its metabolites. The two major metabolites are oxazepam glucuronide and N-desmethylated diazepam. ++++++++++++

 

[natedogg03]

[Whats the average does for xanax and what soes your script usually run? I drank while taking it one night and had trouble remembering what happened. It didn;t make me crazy just very laid back!

 

[paridhm]

Can your family doctor prescribe klonapin or do you need a Psychiatrist?

 

[jlh98765]

Can your family doctor prescribe klonapin or do you need a Psychiatrist?

family doctor

 

[Tux]

itlnstln, you got it wrong. Klonopin is a medium-length benzo, valium has the longest half-life of any benzo we use. The half-life of a drug is measured as the amount of time, following a single dose, that it takes for the drug to reach half the concentration in the blood that it did at its peak level. Chrystal Ashton DM, FRCP, Emeritus Professor of Clinical Psycho-pharmacology, the University of Newcastle upon Tyne, England, gives the half-life of diazepam as 20-100 hours and the active metabolite as 36-200. Your problem was you were trying to compare parenteral half-life with oral. Wherever you got those figures they were vastly wrong. Valium not only has a very long half-life, but it has an active metabolite which prolongs it's effects on the body even longer. That's why valium is so useful in treating withdrawal, it's long half-life keeps a very even blood level in the patient which can be stepped down as gradually as 1mg/day. That being said, I prefer klonopin for daily anxiety over xanax, xanax is too short-acting and is best for panic attacks, not long-term anxiety, and valium tends to build up in one's system, in my case it usually leaves me groggy for half the day when I take it the night before.

 

[itlnstln]

itlnstln, you got it wrong. Klonopin is a medium-length benzo, valium has the longest half-life of any benzo we use. The half-life of a drug is measured as the amount of time, following a single dose, that it takes for the drug to reach half the concentration in the blood that it did at its peak level. Chrystal Ashton DM, FRCP, Emeritus Professor of Clinical Psycho-pharmacology, the University of Newcastle upon Tyne, England, gives the half-life of diazepam as 20-100 hours and the active metabolite as 36-200. Your problem was you were trying to compare parenteral half-life with oral. Wherever you got those figures they were vastly wrong. Valium not only has a very long half-life, but it has an active metabolite which prolongs it's effects on the body even longer. That's why valium is so useful in treating withdrawal, it's long half-life keeps a very even blood level in the patient which can be stepped down as gradually as 1mg/day. That being said, I prefer klonopin for daily anxiety over xanax, xanax is too short-acting and is best for panic attacks, not long-term anxiety, and valium tends to build up in one's system, in my case it usually leaves me groggy for half the day when I take it the night before.

I guess I should "delete" my bookmark for www.rxlist.com

I would have NEVER guessed that they were wrong.

 

[210toosmall]

do you guys feel like anti anxiety meds decrease your intensity in the gym?
and if so how do you cope?

 

[itlnstln]

do you guys feel like anti anxiety meds decrease your intensity in the gym?
and if so how do you cope?

110% - yes