The ex and I had a friend who was bi-polar who didn't think she needed her meds.....she did. We knew within 4 words, written or spoken, whether she had taken her pills or not. Usually because she'd be bawling hysterically over something stupid that happened in an AOL chat room. We finally had to kick her out of our lives and change our number.
once he went on it, i swear, you could TOTALLY tell he was losing his shit. and it wasnt genetics either, because all of his brothers, dad, mom, etc all had thick-ass, italian hair.