Letrozole

[John Juan]

CLICK THE BANNER IN MY SIGNATURE FOR LETROZOLE IN THE RESEARCH LIQUIDS SECTION


Letrozole is currently the most powerful aromatase inhibitor available. It has been shown to reduce estrogen levels by 98% or more. Intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the HPTA, Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was studied in men, and found to significantly increase LH levels to a 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively.

Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. In a similar study 0.02 mg of Letrozole increased testosterone by 45% after 2 days. That same twenty micrograms of Letrozole was also enough, in one study done on men, to reduce estrogen levels by roughly a third. Letrozole has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma level. Letro is best dosed from 0.125-2.5 mgs depending on the desired effect.

 

[Kevlor]

This liquid chem has been getting a lot of attention lately.

 

[Elvia1023]

This is ideal for drying out before a show or when you want to look your best

 

[John Juan]

Letrozole is the strongest estrogen blocker in existence. It takes care of gyno and water retention ASAP.

 

[John Juan]

Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.

AuthorsLoves S, et al. Show all Journal
Eur J Endocrinol. 2008 May;158(5):741-7. doi: 10.1530/EJE-07-0663.

Affiliation
Abstract
OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect.

DESIGN: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m(2)) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months.

RESULTS: Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period.

CONCLUSION: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.

 

[ALIN]

LETROZOLE is one of my personal favorite AI's

 

[Elvia1023]

LETROZOLE is one of my personal favorite AI's

It had such a fast and pronounced effect on the body. For guys carrying lots of water it can make you look like you have dropped a few bf % in a week!

 

[John Juan]

That study shows you only need to take it once a week at <2.5mg. It's powerful which makes dosing very convenient.

 

[gymrat827]

That study shows you only need to take it once a week at <2.5mg. It's powerful which makes dosing very convenient.

Dosing letro once a wk @ 2.5mg.......?? why not .05mg 2-3x a wk?

 

[John Juan]

Dosing letro once a wk @ 2.5mg.......?? why not .05mg 2-3x a wk?

That's fine. I was quoting the human trial
Posted from pubmed.com. Will work either way.