Letrozole

[Elvia1023]

To think I once used 2.5mg ed. 0.5mg eod would be great

 

[John Juan]

To think I once used 2.5mg ed. 0.5mg eod would be great

Hahaha no estrogen in your body. Damn!!!!!

 

[John Juan]

I have heard that letrozole is the most cost effective estro blocker being that you only need to dose it in tiny increments to get maximal effects.

 

[Elvia1023]

Successful use of aromatase inhibitor letrozole i... [Andrologia. 2014] - PubMed - NCBI

 

[Elvia1023]

Aromatase inhibitors for male infertility. [Fertil Steril. 2012] - PubMed - NCBI

 

[John Juan]

An interesting experiment was conducted on a single mega dose of letrozole...
Twenty one days after a single mega dose of 30 mg of Letrozole, serum testosterone level was still increased by 77% above normal.
Pretty intriguing!!!

 

[Elvia1023]

An interesting experiment was conducted on a single mega dose of letrozole...
Twenty one days after a single mega dose of 30 mg of Letrozole, serum testosterone level was still increased by 77% above normal.
Pretty intriguing!!!

Very interesting but you can be the tester for that one

 

[semper03]

Haven't used letro in a few years. Grabbed a bottle from the old chemical needs and dosed it at 0.5 eod or e3d can't remember but it knocked out my gyno quick! Didn't taste too good though lol

 

[pdelta]

Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.

AuthorsLoves S, et al. Show all Journal
Eur J Endocrinol. 2008 May;158(5):741-7. doi: 10.1530/EJE-07-0663.

Affiliation
Abstract
OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect.

DESIGN: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m(2)) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months.

RESULTS: Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period.

CONCLUSION: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.

It seems to me that once a week dosing would be a estro roller coaster ride.

 

[pdelta]

To think I once used 2.5mg ed. 0.5mg eod would be great

2.5 is what the guru's recommend. It sure reduced my gyno at that dosage.