Use of the aromatase inhibitor letrozole to treat male infertility.
AuthorsPatry G, et al. Show all Journal
Fertil Steril. 2009 Aug;92(2):829.e1-2. doi: 10.1016/j.fertnstert.2009.05.014. Epub 2009 Jun 12.
Affiliation
Abstract
OBJECTIVE: Report the case of induction of spermatogenesis with the aromatase inhibitor letrozole.
DESIGN: Case report.
SETTING: University Infertility center.
PATIENT(S): A 31-year-old man with primary infertility, normal volume azoospermia, normal follicle stimulating hormone (FSH) levels and pattern of nonobstructive azoospermia (NOA) on a testicular biopsy.
INTERVENTION(S): The patient was given the aromatase inhibitor letrozole for 4 months and had repeated FSH, testosterone, LH levels, semen analyses, and finally a testicular biopsy.
MAIN OUTCOME MEASURE(S): Results of a testis biopsy.
RESULT(S): Testis biopsy showed normal spermatogenesis following 4 months of letrozole therapy.
CONCLUSION(S): This is the first case report on the use of letrozole to treat male infertility and the first case report on the induction of spermatogenesis in a man with NOA using any aromatase inhibitor.