lab results of Chinese GH: fake!!!

[Sigmund Roid]

Dear all,

There was a lab test of a certain Chinese GH producer, and the material appeared to be N-methionyl GH, which has 192 aminoacids, not 191 amino acids. This gives less effectiveness and more side-effects. Buyers beware!

The not so bad news is that the 18 IU vials indeed contain 18 IU of this worthless shit. PM me for the name of the producer. I am not sure if I am allowed to post it.... Mods?

 

[Sigmund Roid]

I forgot to say, the Met-GH is very pure, there are only small traces of foreign proteins. However, the Met-GH itself can still trigger allergic reactions.

 

[Sigmund Roid]

Here is an article about antibodies caused by usage of Met-GH:
BTW, it says that Met-GH is as effective as natural GH for growth of children. That is good news. Anybody has more info on this? I don't know anymore if Met-GH is useless or not.


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3296637&dopt=Abstract

Acta Paediatr Scand Suppl 1986;325:29-32 Related Articles, Links


Clinical experience with Somatonorm.

Girard F, Gourmelen M.

A total of 21 patients with hGH deficiency was included in a double-blind, randomized, comparative multicentre trial of somatrem (Somatonorm) and pituitary hGH. Owing to the withdrawal of the latter product, only 6 months follow-up can be evaluated. Growth velocities on both preparations were similar, and patients with complete hGH deficiency responded better than those with only partial deficiency. No specific side-effects were noted, but antibodies to hGH were noted in two patients on Somatonorm. Antibodies to Escherichia coli polypeptide (ECP) were found in both groups. In an open study of 14 children treated with Somatonorm, growth velocity increased from a mean of 3.26 +/- 0.42 cm/year to 7.1 +/- 0.47 cm/year during the 1 year of follow-up; in this time, bone age increased by 10 months. No clinical or biological abnormalities were detected, though 50% of the children developed anti-hGH antibodies and 13 out of 14 developed Z scores greater than 0.1 for ECP antibodies, compared with 5 out of 14 before treatment.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 3296637 [PubMed - indexed for MEDLINE]

 

[Sigmund Roid]

Acta Paediatr Scand Suppl 1986;325:25-8 Related Articles, Links


Clinical experience of somatrem: UK preliminary report.

Milner RD.

A total of 63 patients with hGH deficiency were recruited, of whom 59 are evaluable. Somatrem (Somatonorm), 4 IU three times/week, was given either subcutaneously or intramuscularly. Height velocity increased from a mean of 4.7 +/- 2.1 cm/year before therapy to 8.2 +/- 2.6 cm/year in the 15 patients who have been followed for 1 year. In patients with isolated hGH deficiency height velocity increased similarly to the whole group, but in those with multiple pituitary hormone deficiencies the pretreatment and on-treatment growth velocities were lower. Of four children who had previously received spinal irradiation, three experienced only a small increase in height velocity on Somatonorm treatment; the fourth showed a considerable increase in height velocity. Anti-hGH antibodies were present in about 80% of the children tested after 12 months of treatment, but the titres and binding capacities were low. Anti-ECP antibodies were also detected, but again the titres were low, and 39% of the children tested had anti-ECP antibodies before treatment commenced.

Publication Types:
Clinical Trial

PMID: 3296636 [PubMed - indexed for MEDLINE]

 

[Sigmund Roid]

J Pediatr Endocrinol Metab 2002 May;15(5):653-7 Related Articles, Links


Resumption of growth after methionyl-free human growth hormone therapy in a patient with neutralizing antibodies to methionyl human growth hormone.

Pitukcheewanont P, Schwarzbach L, Kaufman FR.

Childrens Hospital Los Angeles, Department of Pediatrics, The Keck School of Medicine of the University of Southern California, USA. [email protected]

A 16-5/12 year-old male was diagnosed with classical growth hormone (GH) deficiency at the age of 8-6/12 years and was treated with recombinant methionyl human growth hormone (m-hGH). Height increased from 104.0 cm to 107.4 cm over the first 6 months. After that, for 1 year, he demonstrated poor growth velocity which was found to be secondary to a high titer of GH antibodies with GH binding capacity >2 mg/l . After a 7-month washout period during which no GH was given, at age 11 years he was placed on recombinant methionyl-free human growth hormone (met-free hGH). His height increased 14.9 cm in 11 months (annualized growth rate of 16.2 cm/year). This report illustrates that evaluation of growth failure during GH therapy should include measurement of anti-GH antibodies so that an appropriate alteration of GH therapy can be made if indicated.

PMID: 12014526 [PubMed - indexed for MEDLINE]

 

[PumpinIronInTn]

What ya say Bough

Well,Is it cheaper than the other brands of GH?
and is it worth using?Mods and vets?

 

[Sigmund Roid]

Here is a link to protropin from Genentech. It also contains 192 amino acids. Anyone had good/bad results from protropin?

http://www.gene.com/gene/products/information/opportunistic/protropin/insert.jsp

 

[applefox]

i don't know, maybe 191 and 192 are both ok and little difference, after all Genetech are very very famous, anybody here use Protropin?

 

[JP@Ironology]

Bump for more.

 

[justwannagetsum]

There was a lab test of a certain Chinese GH producer, and the material appeared to be N-methionyl GH, which has 192 aminoacids, not 191 amino acids. This gives less effectiveness and more side-effects. Buyers beware


Please post brand name or PM me. Thanks!]
JWGS