lab results of Chinese GH: fake!!!

[JP@Ironology]

Sigmond Roid,

What precipated the event that made you take the hGH to a lab to have it tested? Did you suddenly have an adverse reaction or did you start reading scientific publications?

Do get the laboratory report. It is important to establish that an accredited laboratory is performing the analysis. Without a valid laboratory report we are all making assumptions.

It is important that the proper standards, control samples, analytical methods, etc. were used. There are a number of US labs who can test hGH.

Medical Professionals dispense the product. I still need proof that the product is not valid.

JP

 

[Sigmund Roid]

Hi JP,

Well, I bought quite an amount of GH and wanted to know if it was good. I never used it before from Ankebio. The labtest submitted to a Dutch laboratory was on a waiting list for ages and ages (they are very busy), so I started using it after a few months. After 3 months, so the day before yesterday I got the result. The results I have are quite good, lots of strength, control of fat increase during bulking diet and muscle gain. I emailed for the report, and hope to get it tomorrow or the day after. I will post a link to it.

Maybe someone else can do the same labtest in the US as a second opinion?

Sigmond Roid,

What precipated the event that made you take the hGH to a lab to have it tested? Did you suddenly have an adverse reaction or did you start reading scientific publications?

Do get the laboratory report. It is important to establish that an accredited laboratory is performing the analysis. Without a valid laboratory report we are all making assumptions.

It is important that the proper standards, control samples, analytical methods, etc. were used. There are a number of US labs who can test hGH.

Medical Professionals dispense the product. I still need proof that the product is not valid.

JP

 

[kbrkbr]

Hi JP,

Well, I bought quite an amount of GH and wanted to know if it was good. I never used it before from Ankebio. The labtest submitted to a Dutch laboratory was on a waiting list for ages and ages (they are very busy), so I started using it after a few months. After 3 months, so the day before yesterday I got the result. The results I have are quite good, lots of strength, control of fat increase during bulking diet and muscle gain. I emailed for the report, and hope to get it tomorrow or the day after. I will post a link to it.

Maybe someone else can do the same labtest in the US as a second opinion?

I'm not sure I understand. Where did you get this information if the lab didn't give you a report?

 

[kbrkbr]

4 months is not long enough don't worry.

I'd use another one.

Using a different GH(192 in this case) can screw up your GH receptors.

I'll look into it b/c thats just F*cked up.

Fonz

Fonz, could you PLEASE follow up on this. I not only use anke bio, and love the results, but have turned other bro's onto it. It would kill me to think my actions could hurt someone else.

 

[manny78]

Lemme guess, people were buying this stuff cause it was cheaper, right ? Damn.....

 

[Woody]

antibody generation

Study showing production of antibodies low in e coli and mammalian cell line production methods.

Title
Follow-up of antibodies to growth hormone in 210 growth hormone-deficient
children treated with different commercial preparations.
Author
Pirazzoli P ; Cacciari E ; Mandini M ; Cicognani A ; Zucchini S ; Sganga T ;
Capelli M
Address
First Pediatric Clinic, University of Bologna, Italy.
Source
Acta Paediatr, 84(11):1233-6 1995 Nov
Abstract
The aim of the study was to evaluate the immunogenicity of different
commercial recombinant-growth hormone preparations. The presence of
antibodies to growth hormone was tested in 210 growth hormone-deficient
children at 6-month intervals during treatment for 6-66 months. The patients
were treated with three preparations (groups A, B and C of 70 cases each)
having the authentic growth hormone sequence. Groups A and B received
hormone synthesized by the recombinant DNA technique in E. coli, while the
group C preparation was produced in a mammalian cell line. The preparations
showed poor immunogenicity and antibodies were found as follows: 1.4% in
patients of group A (1 case: binding capacity 0.2 mg/l and Ka 3.5 10(7) l
M-1), 2.8% in patients of group B (2 cases; case 1 binding capacity 0.7 mg/l
and Ka 1.5 10(7) l M-1; case 2 binding capacity 0.04 mg/l and Ka of 1.8
10(8) and 6.5 10(6) l M-1), and 8.5% in group C (6 cases; binding capacity
from 0.4 to less than 0.02 mg/l, Ka from 1.6 10(7) to 3.8 10(8) l M-1). Only
two patients of group C presented the antibodies in two subsequent
examinations; in the other patients the positivity was found once. In all
patients positive samples were found at intervals of 6-24 months after the
start of therapy. In all antibody-positive patients growth velocity
presented no decrease at the time of antibody detection and was never
different to that of negative patients. We conclude that the three
commercial preparations examined showed poor immunogenicity without clinical
relevance.
Language
Eng
Unique Identifier
96162282

 

[Woody]

Protropin (192 amino acids)

From http://www.hghtherapymedicine.com/protropin.html showing low number of patients developing antibodies.

Question remains as to what happens to the extra amino acid. I've read posts elsewhere that it drops off upon injection, but I haven't seen studies yet.


ADVERSE REACTIONS
As with all protein pharmaceuticals, a small percentage of patients may develop antibodies to the protein. Growth hormone antibody binding capacities below 2 mg/L have not been associated with growth attenuation. In some cases when binding capacity exceeds 2 mg/L, growth attenuation has been observed. In clinical studies and postmarketing experience of patients treated with Protropin, approximately 0.4 percent of patients screened for antibody production developed antibodies with binding capacities > 2 mg/L at six months. Out of approximately 26,000 patients who have been treated with Protropin, 5 patients have had growth deceleration associated with binding capacities > 2 mg/L. If growth deceleration is observed that is not attributable to another cause, the patient should be tested for antibodies to growth hormone. Although no evidence exists to indicate that the methionine on the N-terminus of somatrem causes antibodies to growth hormone, the physician should consider transferring the patient to somatropin (rDNA origin) for injection, if a patient has antibody binding capacity > 2 mg/L, and has exhibited growth attenuation.

 

[rookie69]

to the guy that asked about somaject and/or export serostim having chinese GH in them, here are two posts to lab reports that showed the somaject contained 191 amino acid sequence, identical to human growth hormone, can't comment on exports though

i've been on somajects for a good while now and never had any injection problems as far as red bumps and such

http://www.anabolex.com/forums/showthread.php?s=&threadid=64249

http://www.fitnessgeared.com/showthread.php?threadid=987

 

[DrJMW]

What chinese GH is this? I have usaed the vials from chinabas** and they were good or seemed to be effective!

Chinabase gets its rHGH from AnkeBio. AnkeBio's HGH is not
m-HGH. It is rHGH, 191 aa and not methionylated. I checked this out months ago. I do not know the Asian producer of m-HGH and I am not convinced that m-HGH is necessarily bad based on the studies posted and the history of Protropin. I can say that some foreign rHGH has a slightly lower (more acidic) pH than the common brands in the USA and Europe. That would explain some of the bad reactions. If you do an IM injection instead of subcutaneous injection, you would avoid the pH problem--you need to go deeper than the adipose/dermal layer to avoid inflamming that area and the muscle tolerates it better.

 

[Woody]

Response from Ankebio

Just received this reply from Ankebio on the question of 192 vs. 191 amino acids.

Dear Mr. xxxx,

Thank you very much for your information!

We also found that there are lots of dicussion on our rHGH regarding the 191 and 192 amino acids on internet, and some of our customers asked us the same questions recently.
Please kindly be informed that we are sure that our rHGH is rDNA original with 191 amino acids.
We don't know why some people spreaded these unreal message again on website, though no clinical reports indicated any different usage for these two rHGH. Maybe becasue the Sale Survey of 2002 showed that we AnkeBio had done best in business of rHGH in China and we have marketed rHGH here for years and covered rHGH market in China. I think that some of competitors in the same trade always would not like our rHGH for so competitive price and the same quality. At the same time, we think that GENETCH INC shall also not like these discussion on website because one of their rHGH products is 192 amino acid which has a very good sale achievements in the past 2002.

For any other question, please feel free to contact me.

Thank you for your time!

Regards,
Yours Sincerely,
Nancy Zhao