Ideal amount of glutamine

[WarriorPL]

What's a good ammount of glutamine to take in a serving, and when should it be taken?

I'm trying to see if it'd be any good to get glutamine in pills, or just the powder.

 

[Mr.X]

What's a good ammount of glutamine to take in a serving, and when should it be taken?

I'm trying to see if it'd be any good to get glutamine in pills, or just the powder.

First, I think glutamine is over-rated. As a general rule, you should do about 10-15g post workout and 20g before bed. Powder is MUCH better then pills, for sometimes w/ the pills they use garbage fillers that drastically slow down tha absorption.

Mr.X

 

[OMEGA]

the best glutamine ever.........next to mine of course




http://shop.store.yahoo.com/buildabody/gforcepeptides.html

 

[Mr.X]

the best glutamine ever.........next to mine of course




http://shop.store.yahoo.com/buildabody/gforcepeptides.html

Glutamine is glutamine.....

"BET EVER"...I don't think so........

Mr.X

 

[OMEGA]

Glutamine is glutamine.....

"BET EVER"...I don't think so........

Mr.X

thats not true darn it

 

[Mr.X]

thats not true darn it

Prove me wrong my man....show some studies comparing glutamine (yours) to at least 5 top brans and 5 lowest brands. The likes of proteinfactory plain glutamine.

Mr.X

 

[OMEGA]

Prove me wrong my man....show some studies comparing glutamine (yours) to at least 5 top brans and 5 lowest brands. The likes of proteinfactory plain glutamine.

Mr.X

I don't have studies, just faith, and results

 

[MS]

I just got back from a conference where a poster was presented showing that chronic oral administration of glutamine decreased the absorption into the blood stream via glutamine transporter down-regulation (much the same as chronic high dose vitamin C does to vitamin-C absorption). The implications of this for BBs is not clear since no one has really shown a benefit from oral glutamine in otherwise healthy and well fed folks on a high protein diet. However IF you wish to take glutamine "just in case", it would seem prudent to cycle it just like most other supps......

 

[Mr.X]

I just got back from a conference where a poster was presented showing that chronic oral administration of glutamine decreased the absorption into the blood stream via glutamine transporter down-regulation (much the same as chronic high dose vitamin C does to vitamin-C absorption). The implications of this for BBs is not clear since no one has really shown a benefit from oral glutamine in otherwise healthy and well fed folks on a high protein diet. However IF you wish to take glutamine "just in case", it would seem prudent to cycle it just like most other supps......

MS as you might know, the debate about glutamine will never end; however, L-glutamine is absolute useless, in my view, unless you use it for its immunological boosting properties.

The simple reason for the above statement is because glutamine has to get into the blood stream one way or another.
As we know, roughly 61% of the AA pool in the blood is glutamine. That is approximately 5g of amino acids in the blood at one time. In addition, close to 90%(probably more) of the ingested glutamine is destroyed by the stomach acids. After the beforehand fact, it is probably safe to assume that not even 1% gets to the blood--less I imagine.

The immunological boosting properties can be explored, I am one of the people that saw this early on and started getting the "ANIMAL" glutamine created by the infamous Animal. What the major contribution in the mix is Potassium Citrate, which should act as a buffering agent. A more prominent way to do this is by adding baking soda to the mix with Glutamin; thus, creating a stomach acid buffer and, maybe, increase some absorption.

Mr.X

 

[MS]

Well we're all entitled to our point of view, but there is no doubt that enough L-glutamine gets orally absorbed in normal folks (without buffering agents) to increase the blood glutamine levels by up to 20% (at 0.3g/kg).

I think the only disagreement is whether this has any advantages for otherwise healthy BBs who are already on a high protein diet. Given that glutamine supps also dramatically increase glutamate levels while decreasing glutathione levels, I would be cautious about taking lots of the stuff all the time. Too much glutamine may also be a risk factor for development of schizophrenia.

The jury may never agree if it's worth taking "just in case" or for any true anticatabolic properties outside of a disease state. Even in a disease state, recent research has shown that not only does increasing blood glutamine levels NOT prevent catabolism in ill folks, but it appears to REDUCE markers of protein synthesis in normal people. We can only speculate that maybe too much glutamine causes feedback inhibition of protein synthesis in some form.

 

[Mr.X]

Well we're all entitled to our point of view, but there is no doubt that enough L-glutamine gets orally absorbed in normal folks (without buffering agents) to increase the blood glutamine levels by up to 20% (at 0.3g/kg).

I think the only disagreement is whether this has any advantages for otherwise healthy BBs who are already on a high protein diet. Given that glutamine supps also dramatically increase glutamate levels while decreasing glutathione levels, I would be cautious about taking lots of the stuff all the time. Too much glutamine may also be a risk factor for development of schizophrenia.

The jury may never agree if it's worth taking "just in case" or for any true anticatabolic properties outside of a disease state. Even in a disease state, recent research has shown that not only does increasing blood glutamine levels NOT prevent catabolism in ill folks, but it appears to REDUCE markers of protein synthesis in normal people. We can only speculate that maybe too much glutamine causes feedback inhibition of protein synthesis in some form.

I've never seen the proof of proper oral absorption that brings about any positive effects to the bodybuilder. The only science I have ever seen had to do with chronically ill patients, and IV infusion. That does not prove anything in my view.

I have seen some literature about glutamine decreasing glutathione levels, but I would second guess that glutahione's function as an essential cofactor for antioxidant enzymes could be replaced with Alpha Lipoic Acid, that was my first outlook on the subject. My guess would be that the propertie glutahione has to electron-donating capacity is linked to its sulfhydryl (-SH) group. I do have to add that if we can can see that glutamine is directly linked to the decrease in glutahione levels then it's time to consider the negative vs. positive of glutamine, for, although gutahione can be substituted in my view, it is still an important water-phase antioxidant that we need.

Again, the same issue comes up, do we really know the anti-catabolic properties through scientific studies done on healthy bodybuilders/athletes. That is the big question, which we all know the answer to: No. When the day comes and I see a study that shows oral ingestion of glutamine is a wide pool of group subjects, from young to old - bodybuilder and not. Then I shall be able to talk about the realistic properties of glutamine, but, for now, the "just in case" theory is just not feasible.

Mr.X