GGT normal, but AST and ALT elevated!!

[Whacked]

NICE! I was hopng you'd hop in

Thanks Ulter!

 

[DIVISION]

The levels show that there are high levels of those enzymes in your blood. Although the liver may be stressed it does not show you have "liver damage" per se, and probably don't with GGT being so low. Those same enzymes can come from muscle damage as well as liver damage. They can jump that high from your weight training if it's intense enough. GGT doesn't come from your muscle but would be elevated if your liver was damaged.

Cool, so basically.......elevated ALT and AST don't necessarily indicate liver damage, GGT being the x-factor here.



DIV

 

[Long Boy]

Same happened to me. it took me 5 months to realize that it wasn't my liver. I ran many cycles before including Steroids and HGH and IGF-1. But when I did the blood test I was clear for 9 months.
my test results was:

AST: 80 (5~42)
ALT: 113 (5~42)
Alkaline Phosphate: 192 (80~306)
CPK Total: 1887 (20~195)
Total Bilirubin: 1.32 (0.2~1.5)
Direct Bilirubin: 0.48 (up to 0.4)
Gamma GT 15.9 (0-49)
Aldolase: 11.5 (up to 7.6)

Then i went to a rheumatologist. she told me the problem should be with my muscles and it's not related to liver. She asked me to stay away from any kind of workout for two weeks and then repeat the blood tests. now I'm waiting for this two weeks to finish then make the test. I will post the result later.

 

[Long Boy]

My test results after 2 weeks without any workout:

AST: 38 (up to 37)
ALT: 102 (up to 41)
LDH: 234 (<480)
CPK: 106 (24~195)

So my CPK reduced from 1887 to 106 which is normal and proves that it was because of intense training. but mu AST and ALT is still elevated!

I did more specific tests for muscles like CRP, Anti Nuclear Antibodies(Hep2)-IgG, anti dsDNA-NcX(EIA) and Anti-Jo-1. all were in normal ranges.

I still don't know that why my ALT is elevated?!

 

[Long Boy]

The levels show that there are high levels of those enzymes in your blood. Although the liver may be stressed it does not show you have "liver damage" per se, and probably don't with GGT being so low. Those same enzymes can come from muscle damage as well as liver damage. They can jump that high from your weight training if it's intense enough. GGT doesn't come from your muscle but would be elevated if your liver was damaged.

Unlike most studies, this was done on people just like you.


Clin J Sport Med. 1999 Jan;9(1):34-9.

Anabolic steroid-induced hepatotoxicity: is it overstated?

Dickerman RD, Pertusi RM, Zachariah NY, Dufour DR, McConathy WJ.

The Department of Biomedical Science, University of North Texas Health Science Center, Fort Worth 76107-2699, USA.

OBJECTIVE: There have been numerous reports of hepatic dysfunction secondary to anabolic steroid use based on elevated levels of serum aminotransferases. This study was conducted to distinguish between serum aminotransaminase elevations secondary to intense resistance training and anabolic steroid-induced hepatotoxicity in elite bodybuilders. DESIGN: This was a case-control study of serum chemistry profiles from bodybuilders using and not using anabolic steroids with comparisons to a cohort of medical students and patients with hepatitis. PARTICIPANTS: The participants were bodybuilders taking self-directed regimens of anabolic steroids (n = 15) and bodybuilders not taking steroids (n = 10). Blood chemistry profiles from patients with viral hepatitis (n = 49) and exercising and nonexercising medical students (592) were used as controls. MAIN OUTCOME MEASURES: The focus in blood chemistry profiles was aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT), and creatine kinase (CK) levels. RESULTS: In both groups of bodybuilders, CK, AST, and ALT were elevated, whereas GGT remained in the normal range. In contrast, patients with hepatitis had elevations of all three enzymes: ALT, AST, and GGT. Creatine kinase (CK) was elevated in all exercising groups. Patients with hepatitis were the only group in which a correlation was found between aminotransferases and GGT. CONCLUSION: Prior reports of anabolic steroid-induced hepatotoxicity based on elevated aminotransferase levels may have been overstated, because no exercising subjects, including steroid users, demonstrated hepatic dysfunction based on GGT levels. Such reports may have misled the medical community to emphasize steroid-induced hepatotoxicity when interpreting elevated aminotransferase levels and disregard muscle damage. For these reasons, when evaluating hepatic function in cases of anabolic steroid therapy or abuse, CK and GGT levels should be considered in addition to ALT and AST levels as essential elements of the assessment.

Hi everybody... Don't let this article fools you (like what it did to me!)
however it looks very reasonable but it's not...
if you have high ALP then doctors test your GGT to see if the source is liver or bones? and it is totally not related to AST and ALT. So if your ALT is that high it should be 90% from your liver.
(sorry for my bad English)

 

[playa@1]

The average American couch potato would seem more at risk for liver problems than those who use anabolics (responsibly). Thinking of fatty liver disease. Seems half the people I meet drink a case of beer a week and 90% eat like crap and never exercise. They are always complaining about aches and pains, go figure, and pounding pain meds. Many do this for years. I'm very surprised how much abuse the human body can endure.