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napsgear
genezapharmateuticals
domestic-supply
puritysourcelabs
Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

Fina vs. 1-AD

Par Deus said:



1-test and fina are quite likely very similar, qualitatively and quantitatively, so there is no reason to do both.

The choice is one of legality and price.

would the 1-test help out with any of the sexual sides experienced with using fina? Thanks
 
Par Deus said:



No, that is lack of estrogen and 1-test does not aromatize. 4-AD or even "andro" would help.

ParDeus

sexual side effects of trenbolone are unrelated to Estrogen... they are PR related.. Progesterone is very important in arousal(partially due to its regulation of GABA)... TREN is a mixed PR agonist/antagonist...

Keep in mind that TREN INCREASES sex drive in some... due to a variance in PR isoforms.
 
The Nature Boy said:
. I'd rather give my money them then some 1-AD reseller.

Yeah, like that bastard Ed Sturm. We all know what a greedy ungrateful prick he is
 
macrophage69alpha said:


sexual side effects of trenbolone are unrelated to Estrogen... they are PR related.. Progesterone is very important in arousal(partially due to its regulation of GABA)... TREN is a mixed PR agonist/antagonist...

Keep in mind that TREN INCREASES sex drive in some... due to a variance in PR isoforms.

OK then, where can one read more about this? Frankly, I am skeptical of everything you just said. Also, it is my understanding that trenbolone is not progestational in the first place

Did you know that progesterones effects on GABA receptors are NOT due to binding to the progestrerone receptor? They are due to non-genomic effects from specific ring A saturated progesterone metabolites , so even if trenbolone were an agonist of the PR and everything else you said were true, your theory just went down the toilet there
 
I'm a little confused here myself, because from user feedback a lot of users said fina gave then unwanted sexual sides, so of course they said USE TEST!!!

Is tren good or bad for sexual function.
 
pa1ad said:


OK then, where can one read more about this? Frankly, I am skeptical of everything you just said. Also, it is my understanding that trenbolone is not progestational in the first place


there are a couple of other studies that confirm this but will have to post them later



Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor.

Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH.

Institut fur Physiologie, Research Center for Milk and Food Weihenstephan, Technical University Munich, Germany.

For the steroidal growth promoters trenbolone acetate (TBA) and melengestrol acetate (MGA) neither the complete spectrum of biological activities nor the potential endocrine disrupting activity of their excreted metabolites in the environment is fully understood. The potency of these substances in [3H]dihydrotestosterone ([3H]-DHT) displacement from the recombinant human androgen receptor (rhAR) and from human sex-hormone binding globulin (hSHBG) was evaluated. In addition, the potency for [3H]-ORG2058 displacement from the bovine uterine progestin receptor (bPR) was tested. For comparison, different anabolics and synthetic hormones were also tested for their binding affinities. For 17beta-trenbolone (17beta-TbOH), the active compound after TBA administration, an affinity the rhAR similar to dihydrotestosterone (DHT) and a slightly higher affinity to the bPR than progesterone were demonstrated. . The affinity of the two major metabolites, 17alpha-trenbolone and trendione, was reduced to less than 5% of the 17beta-TbOH-value. The affinity of these three compounds and of MGA to the hSHBG was much lower compared with DHT. MGA showed a 5.3-fold higher affinity than progesterone to the bPR but only a weak affinity to the rhAR. The major MGA metabolites have an affinity to the bPR between 85% and 28% of the affinity of progesterone. In consequence, MGA and TBA metabolites may be hormonally active substances, which will be present in edible tissues and in manure. We conclude that detailed investigations on biodegradation, distribution and bio-efficacy of these substances are necessary.
 
macrophage69alpha said:


there are a couple of other studies that confirm this but will have to post them later



Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor.


OK, trenbolone might very well have progestational activity. Your theory on libido is still flawed however, because the psychoactive effects of progesterone are 1) not mediated through progesterone but through certain metabolites, and 2) are not mediated through the progesterone receptor.
 
The Nature Boy said:
I'm a little confused here myself, because from user feedback a lot of users said fina gave then unwanted sexual sides, so of course they said USE TEST!!!

Is tren good or bad for sexual function.



I am not debating whether or not tren reduces libido, rather I am debating the cause of the libido decrease

Tren, like 1-AD, reduces libido most likely because it reduces estrogen output in the body. Either that or some mechanism I have not considered
 
Tren, like 1-AD, reduces libido most likely because it reduces estrogen output in the body. Either that or some mechanism I have not considered

So 1AD would be a good addition to 4AD in order to minimize/reduce bloat induced by excess estrogen?
 
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