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We're just starting to learn about many herbals/vitamins, etc. and their effects on both Phase I and Phase II systems.
Look at Beta-Carotene for example. Increases CYP 1A1, 1A2, 3A, 2B1, and 2A, and phase II detox enzymes.
If you're a smoker, this is bad news as an increase in these CYPs increase the rate of procarcinogen to carcinogen metabolism. Furthermore, beta-C is a pro-oxidant in tissue possessing a high partial pressure of O2 (i.e., lungs)
Not surprising that the studies done in the early 90's giving smokers Beta-C increased cancer instead of decreasing it.
Some of the above CYPs are also involved in T metabolism.
Loading up on seemingly harmless OTCs may not be as harmless as we once thought. Problem is, their toxicity is secondary and will take time to surface. A few DNA hits here and there add up.
W6
Look at Beta-Carotene for example. Increases CYP 1A1, 1A2, 3A, 2B1, and 2A, and phase II detox enzymes.
If you're a smoker, this is bad news as an increase in these CYPs increase the rate of procarcinogen to carcinogen metabolism. Furthermore, beta-C is a pro-oxidant in tissue possessing a high partial pressure of O2 (i.e., lungs)
Not surprising that the studies done in the early 90's giving smokers Beta-C increased cancer instead of decreasing it.
Some of the above CYPs are also involved in T metabolism.
Loading up on seemingly harmless OTCs may not be as harmless as we once thought. Problem is, their toxicity is secondary and will take time to surface. A few DNA hits here and there add up.
W6
