macrophage69alpha said:if you dont sit around.. ie you are active this "skeepy" effect will rarely manifest itself.. it seems to be related to the high initial spike in NE levels.. it is seen with yohimbine as well-more commonly as it works exclusively with NE.-- get moving and avoid sleepyness.....btw- that tyrosine makes EVERYTHING(most everything), stimulant wise, work better.
I don't agree. Tyrosine - if you research the net - has a rate limiting step to convert to dopamine and Norepinephrine. Specifically, Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine
and norepinephrine.
Consider:
Tyrosine for depression:
a double-blind trial
by
Gelenberg AJ, Wojcik JD, Falk WE,
Baldessarini RJ, Zeisel SH, Schoenfeld D, Mok GS
Department of Psychiatry,
University of Arizona, Tucson 85724.
J Affect Disord 1990 Jun; 19(2):125-32
We treated 65 outpatients with RDC major depression in a randomized, prospective, double-blind comparison of oral L-tyrosine, 100 mg/kg/day, imipramine, 2.5 mg/kg/day, or placebo for 4 weeks. Tyrosine increased and imipramine decreased 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion significantly, but there was no evidence that tyrosine had antidepressant activity. The only side effect to achieve statistical significance was greater dry mouth with imipramine. MHPG excretion and plasma amino acid concentrations failed to predict or correlate with clinical improvement.
If tyrosine really did convert readily to dopamine and NE - there would definately have been anti-depression activity. I don't believe supplemental tyrosine is worth it. You do not have enough of the enzyme needed for conversion.