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rub out the easy one before you get jiggy with the lady, best remedy for PE there is, and cheap!
Dapoxetine...don't be a 3 pump chump!!!
- Thread starter John Juan
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rub out the easy one before you get jiggy with the lady, best remedy for PE there is, and cheap!
John Juan
New member
[Dapoxetine (Priligy): on demand treatment of premature ejaculation].
Authors
Andrianne R.
Journal
Rev Med Liege. 2013 Dec;68(12):655-60. Article in French.
Affiliation
Abstract
Premature ejaculation (PE) is a common sexual dysfunction, affecting approximately 20-24% of men. Managing PE has been a challenge for physicians and psycho-sexologists as well because no drug for PE has been approved by European (EMA) or U.S. (FDA) drug agencies. Over the past decade, clinical evidence has emerged indicating a beneficial effect of selective serotonin reuptake inhibitors (SSRIs), tramadol, penile anesthesia and, in some cases, inhibitors of phosphodiesterase type 5 for the treatment of men with PE. A psycho-sexological care helps support. In spite of their efficacy, adverse effects represent the major concern for the chronic use of SSRIs in patients with PE and they may prompt discontinuation from therapy. Dapoxetine, marketed as Priligy, is the first compound developed specially for the treatment of PE, on demand before intercourse. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. Dapoxetine is quickly absorbed and eliminated rapidly from the body. Its fast acting property makes it suitable for the on demand treatment of PE.
Authors
Andrianne R.
Journal
Rev Med Liege. 2013 Dec;68(12):655-60. Article in French.
Affiliation
Abstract
Premature ejaculation (PE) is a common sexual dysfunction, affecting approximately 20-24% of men. Managing PE has been a challenge for physicians and psycho-sexologists as well because no drug for PE has been approved by European (EMA) or U.S. (FDA) drug agencies. Over the past decade, clinical evidence has emerged indicating a beneficial effect of selective serotonin reuptake inhibitors (SSRIs), tramadol, penile anesthesia and, in some cases, inhibitors of phosphodiesterase type 5 for the treatment of men with PE. A psycho-sexological care helps support. In spite of their efficacy, adverse effects represent the major concern for the chronic use of SSRIs in patients with PE and they may prompt discontinuation from therapy. Dapoxetine, marketed as Priligy, is the first compound developed specially for the treatment of PE, on demand before intercourse. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. Dapoxetine is quickly absorbed and eliminated rapidly from the body. Its fast acting property makes it suitable for the on demand treatment of PE.
John Juan
New member
Post from a Superior dapoxetine user on another forum...
"I bought some to try so I took a half dose to try out .5ml I'm glad I took only that I lasted a long time and when I wanted to quit I really had to focus on getting off for it to happen. So if I took 2ml it would be porn star stat. Also read about the side effects on it. Glad I have a extra tool for the bedroom. Great stuff it did make me feel tired earlier than normal too."
"I bought some to try so I took a half dose to try out .5ml I'm glad I took only that I lasted a long time and when I wanted to quit I really had to focus on getting off for it to happen. So if I took 2ml it would be porn star stat. Also read about the side effects on it. Glad I have a extra tool for the bedroom. Great stuff it did make me feel tired earlier than normal too."
John Juan
New member
Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries.
AuthorsBuvat J, et al. Show all Journal
Eur Urol. 2009 Apr;55(4):957-67. doi: 10.1016/j.eururo.2009.01.025. Epub 2009 Jan 21.
Affiliation
Comment in
Eur Urol. 2009 Apr;55(4):967-8.
Abstract
BACKGROUND: Dapoxetine is being developed for the on-demand treatment of premature ejaculation (PE). Previous clinical trials have demonstrated its safety and efficacy.
OBJECTIVE: To evaluate the long-term efficacy and safety of dapoxetine in men with PE.
DESIGN, SETTING, AND PARTICIPANTS: This randomized, double-blind, parallel-group, placebo-controlled, phase 3 trial, conducted in 22 countries, enrolled men (N=1162) > or = 18 yr of age who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision criteria for PE for > or = 6 mo, with an intravaginal ejaculatory latency time (IELT) < or = 2 min in > or = 75% of intercourse episodes at baseline.
INTERVENTION: Dapoxetine 30 mg or dapoxetine 60 mg or placebo on demand (1-3 h before intercourse) for 24 wk.
MEASUREMENTS: Stopwatch-measured IELT, Premature Ejaculation Profile (PEP), Clinical Global Impression (CGI) of change, adverse events (AEs).
RESULTS AND LIMITATIONS: The study was completed by 618 men. Mean average IELT increased from 0.9 min at baseline (all groups) to 1.9 min, 3.2 min, and 3.5 min with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively, at study end point; geometric mean IELT increased from 0.7 min at baseline to 1.1 min, 1.8 min, and 2.3 min, respectively, at study end point. All PEP measures and IELTs improved significantly with dapoxetine versus placebo at week 12 and week 24 (p<0.001 for all). The most common AEs were nausea, dizziness, diarrhea, and headache. AEs led to discontinuation in 1.3%, 3.9%, and 8.2% of subjects with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively. Limitations of this study included the exclusion of men who were not in long-term monogamous relationships.
CONCLUSIONS: Dapoxetine significantly improved all aspects of PE and was generally well tolerated in this broad population.
AuthorsBuvat J, et al. Show all Journal
Eur Urol. 2009 Apr;55(4):957-67. doi: 10.1016/j.eururo.2009.01.025. Epub 2009 Jan 21.
Affiliation
Comment in
Eur Urol. 2009 Apr;55(4):967-8.
Abstract
BACKGROUND: Dapoxetine is being developed for the on-demand treatment of premature ejaculation (PE). Previous clinical trials have demonstrated its safety and efficacy.
OBJECTIVE: To evaluate the long-term efficacy and safety of dapoxetine in men with PE.
DESIGN, SETTING, AND PARTICIPANTS: This randomized, double-blind, parallel-group, placebo-controlled, phase 3 trial, conducted in 22 countries, enrolled men (N=1162) > or = 18 yr of age who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision criteria for PE for > or = 6 mo, with an intravaginal ejaculatory latency time (IELT) < or = 2 min in > or = 75% of intercourse episodes at baseline.
INTERVENTION: Dapoxetine 30 mg or dapoxetine 60 mg or placebo on demand (1-3 h before intercourse) for 24 wk.
MEASUREMENTS: Stopwatch-measured IELT, Premature Ejaculation Profile (PEP), Clinical Global Impression (CGI) of change, adverse events (AEs).
RESULTS AND LIMITATIONS: The study was completed by 618 men. Mean average IELT increased from 0.9 min at baseline (all groups) to 1.9 min, 3.2 min, and 3.5 min with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively, at study end point; geometric mean IELT increased from 0.7 min at baseline to 1.1 min, 1.8 min, and 2.3 min, respectively, at study end point. All PEP measures and IELTs improved significantly with dapoxetine versus placebo at week 12 and week 24 (p<0.001 for all). The most common AEs were nausea, dizziness, diarrhea, and headache. AEs led to discontinuation in 1.3%, 3.9%, and 8.2% of subjects with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively. Limitations of this study included the exclusion of men who were not in long-term monogamous relationships.
CONCLUSIONS: Dapoxetine significantly improved all aspects of PE and was generally well tolerated in this broad population.
John Juan
New member
Post in my thread at pm....
"Paired Superior's Dapo with tadalafil on my honeymoon in the DR. All I can say is that I spent more time in our room than I had expected. I pity the poor maid who had to clean up. Lmao.
For me 2ml about 1.5 hours before sex is my sweet spot for Dapo. At this dose I can go as long as I want and then blow on command. On a higher dose I had to really concentrate and needed the wife to talk like a Bangkok whore for me to explode. Crazy! Also, at a higher dose I felt like I was drunk on cheap Vodka.
The only downside is my mouth burning like a mofo when shooing it. Almost feels swollen. Don't know how you could possibly hold this under your tongue for maximum absorption.
I tried other Dapo and nothing did anything like this stuff. I will be taking advantage of any Bogo specials.
As for the tadalafil, it's the first one to not give me a stuffy face feeling. Awesome chems from a great sponsor."
"Paired Superior's Dapo with tadalafil on my honeymoon in the DR. All I can say is that I spent more time in our room than I had expected. I pity the poor maid who had to clean up. Lmao.
For me 2ml about 1.5 hours before sex is my sweet spot for Dapo. At this dose I can go as long as I want and then blow on command. On a higher dose I had to really concentrate and needed the wife to talk like a Bangkok whore for me to explode. Crazy! Also, at a higher dose I felt like I was drunk on cheap Vodka.
The only downside is my mouth burning like a mofo when shooing it. Almost feels swollen. Don't know how you could possibly hold this under your tongue for maximum absorption.
I tried other Dapo and nothing did anything like this stuff. I will be taking advantage of any Bogo specials.
As for the tadalafil, it's the first one to not give me a stuffy face feeling. Awesome chems from a great sponsor."
FitnessSeattle
New member
And a question for the win - what about he opposite problem, male anorgasmia?
snooby1234
New member
What is the shelf life of dapox from superior?
John Juan
New member
If stored in a cool
Dry place the research liquids should all be good for a couple years.
snooby1234
New member
Great - I just ordered some research liquids and am looking forward to conducting some research once they arrive!
Elvia1023
New member
Great let us know how you get on. Did you order the tadalafil too?
snooby1234
New member
I did - should be some fun times!
John Juan
New member
You'll love Superior's liquid orals. I've used MK-677, pramipexole, and tadalafil. All are top notch!
snooby1234
New member
Wow, that was FAST shipping! Ordered Wednesday and received it this morning.
Say... it's the weekend, isn't it. "Mrs. Snooby...."
Say... it's the weekend, isn't it. "Mrs. Snooby...."
John Juan
New member
Wow, that was FAST shipping! Ordered Wednesday and received it this morning.
Say... it's the weekend, isn't it. "Mrs. Snooby...."
Hahaha let the games begin
Elvia1023
New member
Good stuff. They will taste like crap but it will be worth it. Let us know how you get on. With the tadalafil I mix mine in water/juice and you can't taste a thing. With the dapox it's best leaving it under your tongue for 30 secs for maximum absorption.Wow, that was FAST shipping! Ordered Wednesday and received it this morning.
Say... it's the weekend, isn't it. "Mrs. Snooby...."
John Juan
New member
Wow, that was FAST shipping! Ordered Wednesday and received it this morning.
Say... it's the weekend, isn't it. "Mrs. Snooby...."
How's the dapoxetine treating you?
snooby1234
New member
Here is a summary of my research thus far:
Tadalafil - wanting to start cautiously, the research subject consumed ~12.5 mg orally at 9:30 on Friday evening. The liquid was held under the tongue for approximately 10 seconds before being swallowed. The taste was not pleasant, but not overwhelmingly bad either. Not being completely certain how quickly the research liquid would take effect, the research subject left plenty of time between ingestion of the research liquid and the anticipated beginning of stimulating activity. It turned out that interaction with the partner introducing stimulation began at approximately 11:30 on Friday evening. In fact, the mere anticipation of the commencement of the interaction led to visible, measurable results by the research subject. Upon the introduction of direct stimulation, the effects were very noticeable. To put it bluntly, the research subject had a rock hard erection. I will make further comments on this research liquid following my comments on dapoxetine.
Dapoxetine - my research subject has had past experience with an over-seas order of dapoxetine (labeled as Prejac) in pill form. At a 60mg dose with said pill, results were moderately disappointing. Once again wanting to start cautiously, the research subject consumed slightly less than 30mg of the liquid. It was held under the tongue for approximately 8-10 seconds, which was all that the subject could tolerate because of the taste and burn. The subject ended up swallowing the liquid and chasing it with a drink of tap water. Exploration of additional delivery techniques will need to be made. Ingestion occurred at approximately 10:00 on Friday evening. Moving forward to 11:30 and the interaction with the subject's partner, it was reported that physical pleasure was as good as ever, with a noticeable level of control coupled with the ability to enjoy said pleasure. Foreplay was very intensely administered by the subject's partner without any control issues by the research subject. Intercourse was initially controlled by the research subject's partner, largely uninterrupted by direction from the subject to 'slow down' or 'hold off'. The subject's partner THOROUGHLY enjoyed this prolonged level of activity as it is outside of normal for the partner's interactions with the research subject. After a very satisfactory level of activity involving the subject's partner being in control, the research subject assumed control of intercourse and thrusting. Some caution was observed during this phase as the research subject experienced some sense of losing control. The subject resorted to slower thrusting, avoiding heavy thrusting until the research subject decided that it was a good time to bring the research session to a close, which occurred with great pleasure visibly and audibly apparent from both participants. The entire experiment involved 5-6 different positions (depending on how one counts), and concluded at approximately 12:20 a.m.
Conclusions: the dapoxetine liquid clearly had a positive effect on the performance capabilities of the research subject. As noted, 60mg had been ingested previously in pill form. The results from <30mg far exceeded the effectiveness of the pill dosage. With that said, further research involving additional dosages of dapoxetine will be conducted, perhaps increasing to ~40mg and gauging results. While the research subject was very, very pleased with the results from this initial dosage, the subject reports a desire to achieve additional control while in the dominant position. Based on the results achieved from the initial dose of dapoxetine, it seems reasonable to be optimistic that a higher dose will result in even further control. With regard to the tadalafil, the subject was very satisfied with the effectiveness of the research liquid in terms of its ability to produce a very firm erection. The research subject reported continuing to feel the effects of the tadalafil as recently as Sunday moring (~36 hours post ingestion). It is doubtful that the research subject will increase the dosage significantly.
Side effects observed: moderate stuffy nose during the night; resolved by mid-day on Saturday. Slight hang-over effect for a part of Saturday, although not to the level that normal activity was impacted. Numb tongue following dapoxetine ingestion with alcohol taste in mouth for approximately 20 minutes.
Tadalafil - wanting to start cautiously, the research subject consumed ~12.5 mg orally at 9:30 on Friday evening. The liquid was held under the tongue for approximately 10 seconds before being swallowed. The taste was not pleasant, but not overwhelmingly bad either. Not being completely certain how quickly the research liquid would take effect, the research subject left plenty of time between ingestion of the research liquid and the anticipated beginning of stimulating activity. It turned out that interaction with the partner introducing stimulation began at approximately 11:30 on Friday evening. In fact, the mere anticipation of the commencement of the interaction led to visible, measurable results by the research subject. Upon the introduction of direct stimulation, the effects were very noticeable. To put it bluntly, the research subject had a rock hard erection. I will make further comments on this research liquid following my comments on dapoxetine.
Dapoxetine - my research subject has had past experience with an over-seas order of dapoxetine (labeled as Prejac) in pill form. At a 60mg dose with said pill, results were moderately disappointing. Once again wanting to start cautiously, the research subject consumed slightly less than 30mg of the liquid. It was held under the tongue for approximately 8-10 seconds, which was all that the subject could tolerate because of the taste and burn. The subject ended up swallowing the liquid and chasing it with a drink of tap water. Exploration of additional delivery techniques will need to be made. Ingestion occurred at approximately 10:00 on Friday evening. Moving forward to 11:30 and the interaction with the subject's partner, it was reported that physical pleasure was as good as ever, with a noticeable level of control coupled with the ability to enjoy said pleasure. Foreplay was very intensely administered by the subject's partner without any control issues by the research subject. Intercourse was initially controlled by the research subject's partner, largely uninterrupted by direction from the subject to 'slow down' or 'hold off'. The subject's partner THOROUGHLY enjoyed this prolonged level of activity as it is outside of normal for the partner's interactions with the research subject. After a very satisfactory level of activity involving the subject's partner being in control, the research subject assumed control of intercourse and thrusting. Some caution was observed during this phase as the research subject experienced some sense of losing control. The subject resorted to slower thrusting, avoiding heavy thrusting until the research subject decided that it was a good time to bring the research session to a close, which occurred with great pleasure visibly and audibly apparent from both participants. The entire experiment involved 5-6 different positions (depending on how one counts), and concluded at approximately 12:20 a.m.
Conclusions: the dapoxetine liquid clearly had a positive effect on the performance capabilities of the research subject. As noted, 60mg had been ingested previously in pill form. The results from <30mg far exceeded the effectiveness of the pill dosage. With that said, further research involving additional dosages of dapoxetine will be conducted, perhaps increasing to ~40mg and gauging results. While the research subject was very, very pleased with the results from this initial dosage, the subject reports a desire to achieve additional control while in the dominant position. Based on the results achieved from the initial dose of dapoxetine, it seems reasonable to be optimistic that a higher dose will result in even further control. With regard to the tadalafil, the subject was very satisfied with the effectiveness of the research liquid in terms of its ability to produce a very firm erection. The research subject reported continuing to feel the effects of the tadalafil as recently as Sunday moring (~36 hours post ingestion). It is doubtful that the research subject will increase the dosage significantly.
Side effects observed: moderate stuffy nose during the night; resolved by mid-day on Saturday. Slight hang-over effect for a part of Saturday, although not to the level that normal activity was impacted. Numb tongue following dapoxetine ingestion with alcohol taste in mouth for approximately 20 minutes.
John Juan
New member
That sounds like a damn good time. It made me wish I had a woman with me right now. Hahaha thank you for the very detailed review. I look forward to your further experiments with higher doses of dapoxetine.
snooby1234
New member
It was. Yes, it was!
Mrs. Snooby is very impressed with the research results thus far too. I will report further as able.
John Juan
New member
Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine.
AuthorsShabsigh R, et al. Show all Journal
BJU Int. 2008 Sep;102(7):824-8. doi: 10.1111/j.1464-410X.2008.07845.x. Epub 2008 Jul 21.
Affiliation
Abstract
OBJECTIVES: To assess the utility of perceived control over ejaculation ('control') in the evaluation of treatment benefit in men with premature ejaculation (PE), and to compare effects associated with a two-category or greater increase in this variable between men receiving dapoxetine and placebo.
PATIENTS AND METHODS: This subanalysis used combined data from all treatment groups in an integrated analysis of two identically designed, 12-week, double-blind, randomized, placebo-controlled trials of dapoxetine. Men (2614) met the Diagnostic and Statistical Manual of Mental Disorders (fourth edition, text revision) criteria for PE, had a stopwatch-measured intravaginal ejaculatory latency time (IELT) of < or =2 min in > or =75% of events in a 2-week baseline period, and self-reported moderate or severe PE. Men received placebo or dapoxetine 30 or 60 mg, 1-3 h before intercourse. The stopwatch-measured IELT was recorded for each episode; the patient-reported global impression of change (PGI; 7-point scale, 'much worse' to 'much better'), control and satisfaction with sexual intercourse (5-point scales, 'very poor' to 'very good') were assessed monthly. The utility of a two-category or greater increase in control was evaluated by examining the relationship of this variable with IELT and satisfaction with sexual intercourse.
RESULTS: Of 2341 men with baseline and endpoint assessments, 96.8% reported 'very poor' or 'poor' control at baseline, and 748 (32%) reported a two-category or greater increase in control after treatment. More than 95% of those men rated their PE as 'slightly better', 'better', or 'much better' on the PGI; 67.1% gave ratings of 'better' or 'much better.' They also had greater improvements in IELT than men with less than a two-category increase in control, with a mean (sd) change from baseline of 3.7 (4.3) vs 0.77 (1.8) min, respectively, and a greater percentage reported good or very good satisfaction with sexual intercourse than men with less than a two-category increase in control (74% vs 19%, respectively). Nausea, headache and upper respiratory tract infection were the most common adverse events reported by men with a two-category or greater increase in control (15.8%, 7.4% and 6.6%, respectively) and those without (8.5%, 5.5% and 6.5%, respectively). The proportions of men with a two-category or greater increase in control with dapoxetine 30 and 60 mg were 36.3% and 44.5%, respectively (vs 15% with placebo).
CONCLUSIONS: A two-category or greater increase in control (5-point scale) is useful for assessing the treatment benefit in men with PE; it corresponds with improvements in the man's perception of his condition, substantially greater prolongation of IELT, and higher levels of satisfaction with sexual intercourse.
AuthorsShabsigh R, et al. Show all Journal
BJU Int. 2008 Sep;102(7):824-8. doi: 10.1111/j.1464-410X.2008.07845.x. Epub 2008 Jul 21.
Affiliation
Abstract
OBJECTIVES: To assess the utility of perceived control over ejaculation ('control') in the evaluation of treatment benefit in men with premature ejaculation (PE), and to compare effects associated with a two-category or greater increase in this variable between men receiving dapoxetine and placebo.
PATIENTS AND METHODS: This subanalysis used combined data from all treatment groups in an integrated analysis of two identically designed, 12-week, double-blind, randomized, placebo-controlled trials of dapoxetine. Men (2614) met the Diagnostic and Statistical Manual of Mental Disorders (fourth edition, text revision) criteria for PE, had a stopwatch-measured intravaginal ejaculatory latency time (IELT) of < or =2 min in > or =75% of events in a 2-week baseline period, and self-reported moderate or severe PE. Men received placebo or dapoxetine 30 or 60 mg, 1-3 h before intercourse. The stopwatch-measured IELT was recorded for each episode; the patient-reported global impression of change (PGI; 7-point scale, 'much worse' to 'much better'), control and satisfaction with sexual intercourse (5-point scales, 'very poor' to 'very good') were assessed monthly. The utility of a two-category or greater increase in control was evaluated by examining the relationship of this variable with IELT and satisfaction with sexual intercourse.
RESULTS: Of 2341 men with baseline and endpoint assessments, 96.8% reported 'very poor' or 'poor' control at baseline, and 748 (32%) reported a two-category or greater increase in control after treatment. More than 95% of those men rated their PE as 'slightly better', 'better', or 'much better' on the PGI; 67.1% gave ratings of 'better' or 'much better.' They also had greater improvements in IELT than men with less than a two-category increase in control, with a mean (sd) change from baseline of 3.7 (4.3) vs 0.77 (1.8) min, respectively, and a greater percentage reported good or very good satisfaction with sexual intercourse than men with less than a two-category increase in control (74% vs 19%, respectively). Nausea, headache and upper respiratory tract infection were the most common adverse events reported by men with a two-category or greater increase in control (15.8%, 7.4% and 6.6%, respectively) and those without (8.5%, 5.5% and 6.5%, respectively). The proportions of men with a two-category or greater increase in control with dapoxetine 30 and 60 mg were 36.3% and 44.5%, respectively (vs 15% with placebo).
CONCLUSIONS: A two-category or greater increase in control (5-point scale) is useful for assessing the treatment benefit in men with PE; it corresponds with improvements in the man's perception of his condition, substantially greater prolongation of IELT, and higher levels of satisfaction with sexual intercourse.
John Juan
New member
Start with 12.5 mg tadalafil which is 1/3 of the 1.5ml pipette it comes with, and 30mg dapoxetine. Hold each under your tongue for one minute before swallowing. Best absorption comes with an empty stomach. It should kick in within 30-45 minutes.
John Juan
New member
holy shit okay just gave them both to my test subject.. the tadafil went under tounge no issues. The Dapoxetine went under tounge and it burned so bad. They fought through it though. does it need to go under tounge the Dapoxetine or can i just mix in water and give them it to drink it?
John Juan
New member
Mix it and drink it if it's too much to deal with.
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