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CLOMID what, why & How

Realgains

New member
WHAT

Clomid is a mixed estrogen agonist/antagonist. It is mostly used to stimulate ovulation in females as a fertility pill.

Given to men it will raise natural testosterone production, even if one has not been on steroids. Clomid given to healthly men with normal test levels raises test output by 50-300%.

Some natural bodybuilders have used clomid alone for 6-8 weeks with no sides and some improvement in gain.

Clomid is given to high level aerobic athletes that have suffered from training induced hypogonadolism. The results are very positive.

Clomid bind to estrogen receptors at the hypothalamus . This reduces the affect of estrogen at the hypothalamus and thus the hypothalamus puts out more GnRH, the hormone that tells the pituitary to realsease LH and FSH.

So clomid acts by BLOCKING the affects of estrogen at the hypothalamus BUT it also ACTS as an estrogen at the liver and MAY be helpful in maintaining a decent lipid profile, as long as steroid doseage is moderate.

Clomid will block the affects of estrogen at the breast and prevent gyno.

Clomid often will also have an estrogenic affect on the mood resulting in a calming affect, but in a few men it will cause mood swings leading to depressive feelings. I would like to point out that this is quite rare. Most of the mood problem one may expereince post cycle is a result of lowered androgen levels.

BTW....Tamoxifen (nolvadex) is almost an identicle drug and will work in the same way as clomid.

The hypothalamus not only senses androgen output by the testes(testosterone) it also sences estrogen form the aromatization of testosterone. BOTH testosterone and estrogen are envolved in balancing out the amount of GnRH release form the hypothalamus. Too much of either hormone will inhibit natural test production. So in the body there is a constant feedback loop. Not enough androgen and estrogen senced by the hypothalamus causes an increase in GnRH release which in turn tells the pituitary to release more LH and FSH and this tells the testes to produce more testosterone......too much estrogen and testosterone(or any other androgen) will cause a decrease in GnRh release and thus less LH/FSH is relleased from the pituitary and less testosterone is produced.

WHY

Steroid users use clomid at the end of a cycle and after androgen levels have dropped to near normal in order to stimulate higher amounts of GnRh , and LH release. This gets the testes back on the job quickly. We want test production to resume as fast as possible so we can keep more of the muscle gain from a cycle.

PLEASE NOTE: HCG use is also recommended during a cycle to prevent testicular atrophy so clomid will work better. Please see my post on HCG.

HOW

Clomid should be used after androgen levels have dropped to near normal or IT WILL NOT WORK. Some think clomid will help during a cycle but this is a big myth as it is the high levels of androgen that cause suppression during a cycle and not just an elevated estrogen level that results from taking aromatizable gear.

You need to consider two things when planning clomid therapy. #1. The half life of the hormone ester you took, or the time it takes for half of the hormone to clear.
#2. You need to factor in the dose of gear taken.

So Tetosterone in a Cyp or enanthate ester has a half life of about a week. So the common clomid useage starts after two weeks. After two weeks a gram of test cyp will be reduced to about 250 mg and low enough for clomid to start to become affective. BUT if you take 1500mg of test per week then two weeks isn't going to be enough time for androgen levels to drop to the point where clomid is affective.
IF you have taken say 750 of test, 500 of EQ and 400 of deca then androgen levels will not have dropped enough after two weeks to warrent clomid use for two reasons...total dose is higher and both deca and EQ are in a longer acting ester than test cyp.

HEW! After all that said...there is notning wrong with taking clomid too soon as there is no penalty in regard to muscle loss BUT there is a dear penalty to suffer if clomid is started too late..MORE GAINS LOST.

GENERAL GUIDLINES for starting clomid therapy

Clomid has a long half life so you don't need to split up the dose throughout the day except on day one were a loading dose is taken.
Clomid should be taken with food as this helps absorbtion.

Start clomid on day one at about 200-300 mg in divided doses. Then after that take it at 100mg/day for a week and then 50mg for another two or perhaps three weeks . Most have had great results from taking it at 300 on day one and then 50 per day for three-four weeks though.
Now with nandrolone(deca) always take clomid for at least 4 full weeks as nandrolone is often more difficult to recover from.
At any rate take clomid until you feel your sex drive is 100%
Clomid can be safely taken by most men for many weeks with no problems.

SIDES

Clomid can cause blurred vsion in a few men so if that happen then stop taking it and try nolva as it may not cause this problem.
Clomid can cause some acne but nothing like an androgen cycle. Mood swings are uncommon from clomid but can happen in some.

All orals clear very rapidly with half lives of hours and not days.
The same can be said of hormones in PURE SUSPENSION, with no ester molecules to dealy release ie: test suspension.
So with orals you can start clomid the next morning after your last pm dose.

With Deca.....clomid after three weeks off.
EQ....... Clomid after 18 days off
Tren acetate....clomid 3 days after stopping
Sust....clomid after three weeks off
Cyp and enanthate......clomid after two weeks off
Test prop....clomid 3 days after last shot
Test suspension 8 hours after last shot and then same for all the orals
winny taken IM....clomid after about 5 days off. NOTE: IM winny is not in ester BUT the crystal like deposit takes almost a week to clear.

Good luck and lets keep REAL GAINS

RG




:)
 
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Question....

How long is the "maximum" one should use Clomid and at what dosage?

I'm doing the 300/100/50 thing, but that should run out in 4 weeks. What should I look for to know it's done it's job, and how much longer can you take Clomid w/o causing trouble?
 
Re: Question....

Baby Gorilla said:
How long is the "maximum" one should use Clomid and at what dosage?

I'm doing the 300/100/50 thing, but that should run out in 4 weeks. What should I look for to know it's done it's job, and how much longer can you take Clomid w/o causing trouble?

Bill Roberts wrote that in clinical studies, men have taken clomid for a year straight. And that in this regard, it is a rather safe drug.
 
Now for an icky question....

How do you know the Clomid's working/done it's job? Some guys talk about swelling of the testicles, but how much? How long until the signs should appear?
 
Great post! Any other thoughts on raising natural test levels in non steriod users

Unless you are an endurance athelete, probably not. A study done with overtrained cyclists showed increased recovery rates wheter this effect would carry over to a non-overtrained weightlifter is unknown. Also be aware that with the increased test levels comes an increase in SHBG as well, thereby negating any benefits to natural hormone levels unless you hpta is already suppressed. On a side note, some people develop visual tracers while on this medication but the only "side-effect" I ever noticed from it was an uncontrollable tendency to pop wood all day long :horny:
 
Realgains said:
WHAT


So clomid acts by BLOCKING the affects of estrogen at the hypothalamus BUT it also ACTS as an estrogen at the liver and MAY be helpful in maintaining a decent lipid profile, as long as steroid doseage is moderate.

So taking clomid durning a cycle is good for those of us who have high colesterol ? Or is it a wate of clomid?
 
Re: Re: CLOMID what, why & How

Jordaz said:
Realgains said:
WHAT


So clomid acts by BLOCKING the affects of estrogen at the hypothalamus BUT it also ACTS as an estrogen at the liver and MAY be helpful in maintaining a decent lipid profile, as long as steroid doseage is moderate.

So taking clomid durning a cycle is good for those of us who have high colesterol ? Or is it a wate of clomid?

Well Bill roberts has reported that some people benefit from clomid and Bill Llewellyn usesnolva all the time for the same reason and he says it helps but in all honesty if you are taking half decent doses of highly androgenic gear it won't help IMHO. It did nothing for me on my last tren/test cycle.

RG
 
CYPRIOSQUATS said:
Great post! Any other thoughts on raising natural test levels in non steriod users.

Get back up there!
CYPRIO

What about Tribulus,would that be considered a non steroid?Its a herbal supplement but it says on the bottle 45% steroidal saponins,what ever that means.
 
xsnrg said:


What about Tribulus,would that be considered a non steroid?Its a herbal supplement but it says on the bottle 45% steroidal saponins,what ever that means.


I can't comment on that one bro...maybe there are herbs that help...some say Ginsing will help a little.

RG:)
 
Excellent post. Thanks for the info, Realgains. I thought I had done all my homework regarding post-cycle clomid therapy. I'm about to start it, and probably would have wasted 4 boxes by not taking it with food. I need all the help jump-starting the boys I can get.

By the way - I ran a cycle of enanthate @ 500mg for 10 weeks with D-Bol at 30mg per day for the first 5 weeks. I had no probelms with my skin at all, except for a small breakout on the back of one shoulder when I frontloaded my cycle. I recently finished two weeks of HCG/Nolva therapy and my skins a wreck. I had no problems while on, but now it's just plain scary to look at myself. Things fell apart right after I started the HCG/nolva. Any advice on how to manage the skin while using clomid?? I've put off starting clomid because my skin's all f**ked up...

Is it common to have no problems while on, and then have skin trouble while recovering?? I know the hormones are fluctuating big-time.
 
Numberfive said:
Excellent post. Thanks for the info, Realgains. I thought I had done all my homework regarding post-cycle clomid therapy. I'm about to start it, and probably would have wasted 4 boxes by not taking it with food. I need all the help jump-starting the boys I can get.

By the way - I ran a cycle of enanthate @ 500mg for 10 weeks with D-Bol at 30mg per day for the first 5 weeks. I had no probelms with my skin at all, except for a small breakout on the back of one shoulder when I frontloaded my cycle. I recently finished two weeks of HCG/Nolva therapy and my skins a wreck. I had no problems while on, but now it's just plain scary to look at myself. Things fell apart right after I started the HCG/nolva. Any advice on how to manage the skin while using clomid?? I've put off starting clomid because my skin's all f**ked up...

Is it common to have no problems while on, and then have skin trouble while recovering?? I know the hormones are fluctuating big-time.

Sun tan a bit bro.

RG:)
 
Overall I felt the post was a good one, including the time when to start after WHAT product you used and the info about blurred vision. That part is VERY true.

But, your quote that says BTW....Tamoxifen (nolvadex) is almost an identicle drug and will work in the same way as clomid." is incorrect.

the key word here is "ALMOST" and at that, I mean it works as an anti-estrogen. Nolvadex does NOTHING to raise your natural test levels like Clomid does.
 
Shinobi said:
Overall I felt the post was a good one, including the time when to start after WHAT product you used and the info about blurred vision. That part is VERY true.

But, your quote that says BTW....Tamoxifen (nolvadex) is almost an identicle drug and will work in the same way as clomid." is incorrect.

the key word here is "ALMOST" and at that, I mean it works as an anti-estrogen. Nolvadex does NOTHING to raise your natural test levels like Clomid does.

You are saying things that you really shouldn't bro. Nolvadex will also block estrogen receptors at the hypothalamus bro and some even think it is superior to clomid. Bill Llewellyn has a study to back that.

I have used both nolva and clomid post cycle and both work well .
http://www.mindandmuscle.net/magazine/i6clomid.html

If that link doesn't work then just do a search for " Bill Llewellyn and nolvadex " on Yahoo.


RG:(
 
14 days or 18 days?

I am on 500MG TEST EN & EQ. Will use HCG @ week 5-7. Planning on 11 weeks. Will stop both at the same time. therefore, I am assuming to be on the safe side I should start after two weeks? Then stay on clomid for three weeks. In addition. I will start HCG during week 9 -10 of cycle. Any changes?
 
Re: 14 days or 18 days?

robsatx said:
I am on 500MG TEST EN & EQ. Will use HCG @ week 5-7. Planning on 11 weeks. Will stop both at the same time. therefore, I am assuming to be on the safe side I should start after two weeks? Then stay on clomid for three weeks. In addition. I will start HCG during week 9 -10 of cycle. Any changes?

Sounds okay but you could wait for about 18 days after the last shot of EQ before starting clomid. Be sure to do a loading dose of clomid at 300mg in divided odoses with food on day one.

RG:)
 
Numberfive said:
Excellent post. Thanks for the info, Realgains. I thought I had done all my homework regarding post-cycle clomid therapy. I'm about to start it, and probably would have wasted 4 boxes by not taking it with food. I need all the help jump-starting the boys I can get.

By the way - I ran a cycle of enanthate @ 500mg for 10 weeks with D-Bol at 30mg per day for the first 5 weeks. I had no probelms with my skin at all, except for a small breakout on the back of one shoulder when I frontloaded my cycle. I recently finished two weeks of HCG/Nolva therapy and my skins a wreck. I had no problems while on, but now it's just plain scary to look at myself. Things fell apart right after I started the HCG/nolva. Any advice on how to manage the skin while using clomid?? I've put off starting clomid because my skin's all f**ked up...

Is it common to have no problems while on, and then have skin trouble while recovering?? I know the hormones are fluctuating big-time.


I find that my skin gets bad at the end of a cycle and actually gets better with clomid usage. I believe that acne is from fucked up hormones and the sooner you get them back to normal, the sooner your skin clears, IMO.
As for your skin I use rubbing alcohol and makeup pads. Very cheap and fries acne. If you use it the pad will be brown with dead skin, oil, etc.
 
HorseBalls said:



I find that my skin gets bad at the end of a cycle and actually gets better with clomid usage. I believe that acne is from fucked up hormones and the sooner you get them back to normal, the sooner your skin clears, IMO.
As for your skin I use rubbing alcohol and makeup pads. Very cheap and fries acne. If you use it the pad will be brown with dead skin, oil, etc.


Ya ...clomid really isn't bad on the skin...a few zits maybe but nothing like androgen use.

RG
 
speaking of clomid... I just ended my cycle 3 days ago and took 300mg this morning.. My nuts went from small to larger than they were pre-cycle within a day. Damn this stuff is no joke.
 
Good info RG. But you probably already know my opinion on this but I'll chime in as the devils advocate anyway.

I believe 90% of of the people who use CLomid, don't need it.

In some people it helps. In others, it makes matters worse. Interesting to hear your conclusions that with a reasonable cycle it had no effect.

Clomid is a crapshoot. As RG said, androgen levels must be high in order for it to impart its effect. But how high is high?
It varies from individulal to individual but too many people seem to think Clomid is a "why not" drug, or a "playing it safe" drug. Then they wonder why a month after their cycle they still have no dick.
 
Numberfive said:
Excellent post. Thanks for the info, Realgains. I thought I had done all my homework regarding post-cycle clomid therapy. I'm about to start it, and probably would have wasted 4 boxes by not taking it with food. I need all the help jump-starting the boys I can get.

By the way - I ran a cycle of enanthate @ 500mg for 10 weeks with D-Bol at 30mg per day for the first 5 weeks. I had no probelms with my skin at all, except for a small breakout on the back of one shoulder when I frontloaded my cycle. I recently finished two weeks of HCG/Nolva therapy and my skins a wreck. I had no problems while on, but now it's just plain scary to look at myself. Things fell apart right after I started the HCG/nolva. Any advice on how to manage the skin while using clomid?? I've put off starting clomid because my skin's all f**ked up...

Is it common to have no problems while on, and then have skin trouble while recovering?? I know the hormones are fluctuating big-time.

As I recall vitamin B5 in large amounts is helpful
 
Nelson Montana said:
...Then they wonder why a month after their cycle they still have no dick.

I agree 100%... Clomid can bring your test production back but that doesnt mean if you stop clomid the production will continue
 
I have talked to an ongoing endrocrinologist at my department and he only laughed, when I told him about Clomid therapy after heavy androgen use. He said that something like 750mg of test for 12 weeks will totally screw your axis and there´s nothing you can do about it besides waiting for it to kick back in, which will take at least 6 months in most individuals. In some it will take a year ot two.
He said that Clom or other anti-e´s might temporarily increase test levels, but they´ll drop back to zero after dicontinuing the drugs. According to him you should taper off very slowly using very little amounts of test prop for many weeks after heavy androgen use to prevent a dramatic crash and then just stop. A lot of Zinc for the next months might help as well (like 100mg/day)
 
Realgains said:



Ya ...clomid really isn't bad on the skin...a few zits maybe but nothing like androgen use.

RG

In the modern age, clomid is utter garbage.

Cabergoline+proviron is a MUCH, MUCH better option.

Fonz
 
gainerxxl said:
I have talked to an ongoing endrocrinologist at my department and he only laughed, when I told him about Clomid therapy after heavy androgen use. He said that something like 750mg of test for 12 weeks will totally screw your axis and there´s nothing you can do about it besides waiting for it to kick back in, which will take at least 6 months in most individuals. In some it will take a year ot two.
He said that Clom or other anti-e´s might temporarily increase test levels, but they´ll drop back to zero after dicontinuing the drugs. According to him you should taper off very slowly using very little amounts of test prop for many weeks after heavy androgen use to prevent a dramatic crash and then just stop. A lot of Zinc for the next months might help as well (like 100mg/day)


To be blunt this doc knows shit about androgen use......my endochrinologist would laugh in his face.(as would Ulters doc)

Tapering does nothing!!! It doesn't take much androgen to shut down the HPT axis TOTALLY so tapering is bullshit. The idea is to get the androgen OUT OF THE SYSTEM as QUICKLY as possible so the axis can start to normalize.
Clomid does help as it causes a higher than normal LH secreation post cycle and this stimulates the testes more rapidly.
Also, estrogen is more inhibitory than testosterone so if you block its affect on the hypothalamus test output really improves.AND PLEASE nobody better tell me that testosterone is more inhibitory on HPTA than estrogen!

RG:)
 
gainerxxl said:
I have talked to an ongoing endrocrinologist at my department and he only laughed, when I told him about Clomid therapy after heavy androgen use. He said that something like 750mg of test for 12 weeks will totally screw your axis and there´s nothing you can do about it besides waiting for it to kick back in, which will take at least 6 months in most individuals. In some it will take a year ot two.
He said that Clom or other anti-e´s might temporarily increase test levels, but they´ll drop back to zero after dicontinuing the drugs. According to him you should taper off very slowly using very little amounts of test prop for many weeks after heavy androgen use to prevent a dramatic crash and then just stop. A lot of Zinc for the next months might help as well (like 100mg/day)




Are you serious....HPTA axis recovery does NOT take 6 months to over a year!
Maybe nandrolone use will scew one up for 4-6 months if no clomid is used post cycle or HCG during the cycle as nandrolone is the worst roid in regard to recovery issues.
GnRH and LH recovery is fast in most men ....its the small testes that take some time to recover but not 6 months to a year or more! This guy is a QUACK!
HCG will get the testes back to 100% in a matter of weeks before a cycle ends BTW....see my post on HCG.

RG

:(
 
Last edited:
Clomid is the recovery drug of choice for one of the most brilliant endocrinologists on the planet who works quite extensively with A/S using strength athletes/BB'ers,Dr.Raymond Scruggs.He has the chartwork of thousands of patients to offer as an iron clad testimonial regarding its effectiveness in the recovery regimen.It is a must have drug in the cycling arsenal.
 
Huck: I know a few dozen people, myself included, who wouldn't be in that list of testimonials. Every time I used Clomid I had virtually no ejacuate. I even used it once in between cycles -- same thing. It was like...drip. The end. I'm sure there are others who will concur with this.

RG: It doesn't matter if testosterone is MORE inhibitory than estrogen. One can have normal estrogen and still be inhibited, in whch case even if the Clomid worked, it wouldn't help.

It seems that tapering goes in and out of fashion. A while ago I would have agreed that it was pointless. But it seems as if coming off of a cycle and using Androgel, which has a natural peak and valley to it, can help get the HPTA back on its feet somewhat.

It is very possible to be supressed for up to a year. That's a fact.

As far as HCG getting the testes back 100% -- not really. If you're over 40 or have used roids extensively, your HPTA may not be able to take over once the effects of the HCG are gone. You can drop right back down again.

It's time some of you younger guys come to grips with the fact that there isn't a drug to cure everything.
 
Every cycle I did from 1983 until 1999 I crashed using the tapering method. After 1999 I didn't crash anymore. That's because in 1999 I started using clomid post cycle. There is no reason to not use it unless you find the sides unacceptable. What most people, like Nelson, believe is the clomid holding there natural test back, is usually androgens still present when they come off. Like deca.

Also, this ridiculous notion that keeps getting floated here about 250mg/wk not shutting you down as hard as 500mg/wk has to end. That is simply not true and it was proven by the U of Iowa Study years ago. Look it up.


Tapering is a joke and any endo who suggests it has NO EXPERIENCE with the cycling population. TAKE YOUR CLOMID.
 
Realgains said:


Clomid given to healthly men with normal test levels raises test output by 50-300%.

:)

I have no idea where you pulled that from, but it is utter nonsense.

Clomiphene will only elevate your test levels to the upper normal range if they are low.

Fonz
 
I experience visual disturbances and headaches on clomid. I started taking it right before i went to bed and had no real problems. From my understanding i am not risking any permanent damage. Would anyone disagree? Just want to ask some of the experts here to make sure... appreciate it.
 
Realgains did u write this article? Im asking cause it looks so familiar and you mentioned Bill Llewellyn... I think he wrote the Anabolics 2000
Another ? Why would you use Nolva only post cycle? It only blocks estrogen and does nothing to bring back your testes
 
Well, lets face it anything we take is just a bandaid to hopefully speed recovery, in the end for the body to normalize it will just take time. There are too many variable I feel to say one method works best.

In regards to clomid, it will raise LH and in turn test not only in oligozoospermic and normospermic men.

The effect of clomiphene citrate on sex hormone binding globulin in normospermic and oligozoospermic men.

Adamopoulos DA, Vassilopoulos P, Kapolla N, Kontogeorgos L.

The effect of clomiphene citrate (CG) on sex hormone binding globulin (SHBG) was studied in 10 oligozoospermic patients with varicocele and 6 normospermic men. Plasma SHBG, testosterone (T), oestradiol (E2), FSH, LH, Prolactin (Prl), thyroxine (T4) and 17-OH-progesterone (17-OH-P) were determined before and during medication. SHBG concentration rose from 38.1 +/- 18.3 to 54.3 +/- 16.0 nmol/l (P less than 0.01), while T and E2 showed significant increases from 31.2 +/- 10.8 nmol/l and 24.6 +/- 5.4 pg/ml to 52.0 +/- 3.6 and 43.3 +/- 14.9, respectively in the oligozoospermic patients, with similar rises noted in the normospermic men. FSH, LH and 17-OH-P were markedly elevated while on CC, but Prl and T4 remained unchanged. The findings of this study indicated the CC causes an increase of SHBG concentration, which is probably related to the rise of E2 concentration. This SHBG change, combined with the intrinsic oestrogenic activity of CC might be one of the factors responsible, through a decrease of free T and a T to E2 imbalance, for the lack of significant effect on parameters of seminal quality in so treated patients.
 
Lift Chief said:
I experience visual disturbances and headaches on clomid. I started taking it right before i went to bed and had no real problems. From my understanding i am not risking any permanent damage. Would anyone disagree? Just want to ask some of the experts here to make sure... appreciate it.

That's right, you won't cause any damage.
 
Re: Re: CLOMID what, why & How

Fonz said:


I have no idea where you pulled that from, but it is utter nonsense.

Clomiphene will only elevate your test levels to the upper normal range if they are low.

Fonz



I can't get the damn link to come up but here is a quote from a good study listed on PubMed.com


"After CC(clomiphene citrate) administration, mean serum total T and non-SHBG-bound levels in young men increased by 100% & 304% respectively..."

These were normal men that were not coming off roids.

RG



:)
 
Shinobi said:
Realgains did u write this article? Im asking cause it looks so familiar and you mentioned Bill Llewellyn... I think he wrote the Anabolics 2000
Another ? Why would you use Nolva only post cycle? It only blocks estrogen and does nothing to bring back your testes


Bill wrote the article in the link bro...I wish I had half his brains.

Yes he wrote Ananbolics 2000 and Anabolics 2002..I bet 2004 will be even better.

Bill does recommend HCG but only in several large shots post cycle with clomid spread out over many days. That will work but will likely delay HPTA recovery....but he is worried that daily shots during the cycle will desensitize the testes to LH. See my HCG post.

Nolva works in the same way as clomid bro as both block the inhibitory affect of estrgen at the hypothalamus and thus speed recovery.

RG
:)
 
They were healthy other than the fact that they had low test levels. Clomid will not and arimidex will not and nolva will not raise your test levels above normal.

I saw this posted in a rant by Bill's ex-partner and it bears repeating. Bill L got most of his information right here 3 years ago when this board was in it's renaissance period. Unfortunately he didn't grow in knowledge along with the rest of the community and is still stuck in the 90's with his beliefs.
 
Ulter, have you ever heard of the Clomiphene Challenge Test? It is a routine procedure performed by doctors to test the HPA:

http://www.merck.com/pubs/mmanual/section19/chapter269/269g.htm

"Clomiphene citrate test: Clomiphene citrate is a weak estrogen that inhibits the binding of estradiol on estrogen receptors and does not stimulate receptor activation. Because estradiol is an important inhibitor of serum gonadotropin secretion, receptor occupancy by clomiphene causes decreased negative feedback on gonadotropin secretion by circulating estrogens.The normal adult response to clomiphene citrate, 100 mg po bid, is a 50 to 250% increase in LH, a 30 to 200% increase in FSH, and a 30 to 200% increase in testosterone These increases are impaired or are absent in hypothalamic or pituitary disorders."

There is no question that clomid raises testosterone levels in normal healthy males.

Here is another abstract of interest:

J Clin Endocrinol Metab 1987 Dec;65(6):1118-26

The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate.

Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ.

Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, Washington.


Serum testosterone (T) levels in men decline with age while serum LH levels, as measured by RIA, increase. To assess if the decline in serum T levels in healthy aging men is paralleled by an age-related decline in the bioavailable non-sex hormone-binding globulin (SHBG)-bound fraction of T and to determine whether there are age-related changes in LH secretion or LH control of T production, we studied 29 young (aged 22-35 yr) and 26 elderly (aged 65-84 yr) healthy men . All men had single random blood samples drawn, and 14 men in each age group underwent frequent blood sampling for 24 h, both before and after 7 days of clomiphene citrate (CC) administration. Both mean 24-h serum total T levels and non-SHBG-bound T were reduced in elderly men compared to those in young men (P less than 0.05), while estradiol and SHBG levels were similar in the 2 age groups. Serum FSH determined by RIA and LH by RIA and bioassay were higher in the elderly men compared to those in young men (P less than 0.05), but the ratios of LH bioactivity to immunoreactivity and the LH pulse frequency and amplitude were similar. After CC administration, mean serum total T and non-SHBG-bound levels in young men increased by 100% and 304%, respectively, while in older men these values increased by only 32% and 8%, respectively. However, CC-stimulated LH pulse characteristics and serum levels of estradiol, SHBG, FSH, and bioactive and immunoreactive LH were similar in the 2 groups. Thus, both at baseline and after CC stimulation, elderly men had significantly lower serum total T and non-SHBG-bound (bioavailable) T levels than did young men, despite similar or increased levels of bioactive LH and similar bioactive to immunoreactive LH ratios and LH pulse characteristics. These results suggest that major age-related changes in the hypothalamic-pituitary-testicular axis occur at the level of the testes and are manifested by decreased responsiveness to bioactive LH. Administration of CC to young and elderly men resulted in similar changes in LH pulse characteristics and LH bioactivity and immunoreactivity, suggesting preserved hypothalamic-pituitary responsiveness in the elderly.
 
ulter said:
Ok thanks Nandi. I will have to do more research into why this increase doesn't occur in my own test levels or any of those patients at Dr Scruggs office. He is saying that this is not what he has observed.
Ulter, is Scruggs checking levels when people run clomid post cycle or on those who are using clomid AFTER HPTA has recovered? The abstracts above point to normal men, who are not trying to recover from AAS use.
 
Zyglamail said:
The abstracts above point to normal men, who are not trying to recover from AAS use.

Exactly.

Fonz
 
Fonz said:


Exactly.

Fonz
Well, lets face it, all meds that increase test levels do so by fooling the system into thinking one or more feedback mechanisms are low and in turn triggers a response. If test is allready low due to comming off cycle I think your going to be in the same boat using any one of them. However, some work better than others for certian people. In the end time is what will restore HPTA.
 
He has done both actually. He was a nolva-HCG guy until me and some other patients kept bugging him about clomid back in early 2001. So he tested post cycle and then he tested patients who hadn't cycled for the first time yet. He said he did not see an increase in T levels above baseline after the "never cycled" patients used clomid. Of course vast majority of the tests were on post cycle patients. They only got back to normal and didn't have an increase over baseline either. But then that was expected.
 
He has done both actually


That is very surprising that there was no T increase in the "never cycled" group. That definitely seems to contradict the published literature.

I could understand, and expect, no or minimal increase in T in someone who has just finished a cycle, since the testicular Leydig cells have probably atrophied to the point where they are not capable of producing T in response to clomid.

My understanding of the rationale for using clomid is to prevent rising post cycle estrogen from acting in a negative feedback manner to blunt LH secretion, which would prevent normal Leydig cell recovery. The clomid is not intended to boost testosterone levels immediately, like during a Clomid challenge test in normal people.

So the fact that Dr. Scruggs saw no T increase with clomid post cycle isn't what surprises me, it's his results in normal people.
 
ulter said:
He has done both actually. He was a nolva-HCG guy until me and some other patients kept bugging him about clomid back in early 2001. So he tested post cycle and then he tested patients who hadn't cycled for the first time yet. He said he did not see an increase in T levels above baseline after the "never cycled" patients used clomid. Of course vast majority of the tests were on post cycle patients. They only got back to normal and didn't have an increase over baseline either. But then that was expected.
Out of curiosity, what was the dose of clomid used and at what point in the clomid therapy did he check test levels?
 
ulter said:
100mg/day, which is his normal prescription, and I had mine on the 14th day. I can't speak for anyone else.
LOL, dont ya just love science. DOesnt it figure that something as simple as taking clomid and checking LH and T levels cant even be reported with any consistancy :)
 
Yeah how bout it.

Dr Scruggs posted on AF that we are all just jacking off if we think we are going to find any formulas or "rules" that apply to endocrinology because there is just too little known about it. I let the post stand because it was him of course.
He takes each case individually and that's right. He doesn't think much of people like Bill Roberts, Bill Llewellyn, etc who he calls "armchair endocrinologists" because they make statements about what works or doesn't for everyone. And they do it with no worries of liability or recourse.
 
we are all just jacking off if we think we are going to find any formulas or "rules" that apply to endocrinology because there is just too little known about it.


It's hard to argue with that when you see the variations in the responses of so called normal people when challenged with Clomid: a 30% to 200% increase in testosterone is an awfully large spread. Obviously everyones HPA really is different when it comes to responding to Clomid, and likely so with HCG or Nolvadex as well.
 
I'm going long....

JP@Ironology said:
Just started my clomid today :bawling:

I've been doing mine into my 3rd week. I've gotten more to draw it out another 50 days. Gonna make sure the boys should be working and then get tested a couple months later to be sure it's all AOK. :p
 
Shinobi said:
Realgains did u write this article? Im asking cause it looks so familiar and you mentioned Bill Llewellyn... I think he wrote the Anabolics 2000
Another ? Why would you use Nolva only post cycle? It only blocks estrogen and does nothing to bring back your testes

actually from the studies i have seen Nolvadex mg for mg works better then clomid at bring back your testes plus has an added benefite of being a better anti-E
 
There you have it. Everyone do HCG, clomid, and nolva. At least if you lump them all in one basket you are bound to come out a winner with one of them.
 
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