Depending on your routine, and your goals, i would recomend, keeping one real heavy movement early in your routine. I personally do this, to keep my strength up, and it makes me feel like I'm keeping size. The rest of my movements for tha body part, I use high reps and short rest periods. Here is an example.
Legs
sets reps
Squat 2-3 4-6
Leg Press 1-2 15-20
Leg ext 1-2 15-20
Leg curl 1-2 15-20
This is not all I do, at times I'll utilze super and compound sets. Hope this is helpful.