For me, I already do 10-8-6 w/ the heaviest weight I can lift that much... But recently I've been doing 4-5 sets w/ 2-4 reps... and basically maxing out on my last set... I've found that after doing the 10-8-6 for a while, this heavier weight, w/ less reps really tears up my chest!!!
SO... maybe if you've already been doing the 10-8-6 type thing... add more weight, drop reps down a bit, and ad another set...
One quote I saw on here once that I try to think about is, The best work-out routine is the one you haven't been doing!
When ever you change something up, you force your body to react to that change, and usually this reaction is muscle mass!