You're asking the wrong question, I believe. The top indicators would be blocked arteries. But I think you mean predictors which is what a lipid profile is meant to do. I don't think there is such a thing. The main cause from what I have seen is sat fat and a sedentary lifestyle. So a 50 year old man weighing 350 with a car floor full of Big Mac and Krispy Kreme wrappers would be a picture of good predictors.