Do you know what profit is? It's all about benjamins yo. Even if it made as much money as twilight (i doubt) - twilight will still make 5x more profit cuz it cost way less.
End of the day: Do you want to be a avatar producer or a twilight producer? Which will allow you to buy your own island?
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Producers I can understand, they'd literally shit out a movie if they knew it'd sell. As for whomever was at the helm creating any given piece of entertainment, that would be completely fucked up if $$ was the ultimate motive. Sure, just like Titanic, the profit margin of Avatar is a fraction of Twilight's, but what movie do you want to be remembered for making? Some teenybopper geigh-fest that people will laugh at 10 years from now (actually most people already are) or a cinematic masterpiece that will stand the test of time, help serve as a study guide for future film techniques, always being one of the first movies preserved/remastered for new formats, etc.
Actually, all things considered, it's highly likely Titanic has "made" more than Twilight ever will at this point, because it's a solid movie. Over the course of the next decade Avatar will probably do the same. The difference is, Cameron will still be respected a decade from now, whereas Hardwicke and Weitz are already lol.