alcohol is detrimental, paricularly in certain ethnic groups, but its also a facet of many cultures and social activities.
if you are going to drink
at least take sesamax (or other sesamin product)
here is why
Biosci Biotechnol Biochem. 2005 Jan;69(1):179-88.
Modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver: a DNA microarray study.
Sesamin, a major lignan in sesame seeds, has multiple functions such as cholesterol-lowering and anti-hypertensive activities. To investigate the effect of sesamin on gene expression in the liver, a DNA microarray analysis was carried out. The ingestion of sesamin dissolved in olive oil up-regulated the expression of 38 genes, 16 of which encode proteins possessing a lipid-metabolizing function, and 16 of which encode proteins possessing a xenobiotic/endogenous substance metabolizing function. In particular, sesamin significantly increased the expression of beta-oxidation-associated enzymes in peroxisomes and auxiliary enzymes required for degradation, via the beta-oxidation pathway, of unsaturated fatty acids in mitochondria. The ingestion of sesamin also resulted in an increase in the gene expression of acyl-CoA thioesterase involved in acyl-CoA hydrolase and very-long-chain acyl-CoA thioesterase. Interestingly, it induced the expression of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme. These results suggest that sesamin regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level.
there are other supplements that can also help, most of which are related to liver function, the main benefit of sesamin (that others do not have is the impact on aldehyde dehydrogenase- aldehydes are responsible for much of the negative effects of alcohol consumption)