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Ala

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riskybizz007

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ALA prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.



Aguirre N, Barrionuevo M, Ramirez MJ, Del Rio J, Lasheras B.




Department of Pharmacology, School of Medicine, University of Navarra,


Pamplona, Spain.




A single administration of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg, i.p.), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine (5-HT) content and [3H]paroxetine-labeled 5-HT transporter density in the frontal cortex, striatum and hippocampus by 40-60% 1 week later. MDMA treatment also increased glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus. Repeated administration of the metabolic antioxidant alpha-lipoic acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did not prevent the acute hyperthermia induced by the drug; however, it fully prevented the serotonergic deficits and the changes in the glial response induced by MDMA. These results further support the hypothesis that free radical formation is responsible for MDMA-induced neurotoxicity.
 
riskybizz007 said:
This is my fav. supplement, so just adding a little bit more info to what we already know it does.
Click to expand...
What exactly has ALA done for you bro, i've tried it at 750mg per day and really didn't notice anything amazing about it, how much do you take and what benefits have you received from it??????
 
Let me start off by saying, not all supplements are created equally, at least that's my opinion. I've tried NowFoods ALA at the same doses you took and didn't feel any different. The ALA i order from beyond-a-century.com i assume is a much better quality. ALA you have to be careful w/ it, it cannot be exposed to light or oxygen for too long a period of time, so don't ever buy the powders, or think the ALA in your creatine mix is worth a crap either.

Now why I like ALA so much... First off it allows your muscle to hold on to more glycogen thus lowering your blood sugar. This will make your muscles feel much more full, and because of that you will have some pretty massive pumps in the gym b/c of that fullness especially in my arms. Also, it is a potent antioxidant, both water soluble and fat soluble. Other than that it is a great liver protector. Moreover, it can deprive your fat cells of glycogen b/c most of it will be shuttled to the muscles. Also b/c of this you can say it is in a way anticatabolic as well. I find this supplement to work awesome when on a low carb diet, or for getting into ketosis much faster. And since it lowers your blood sugar you can also use it to help increase hunger if you take it b/w meals. Now if you read all of that, you'd see why this is my favorite supplement around.
 
I totally feel ALA from Now. I have the powder from Beyond a century and I feel that too.

I loveeeeee tha continous exploding pump feeling i get throughout the day, but you know what, I discovered that I get the EXACT same feeling when I eat Healthy Fats and 300grams of protein and up a day.
 
So when is the best time to take ALA? I want to use it for the antioxidant and glycogen shuttling effects. I do want to avoid the hunger inducing effect so I don't go eating everything in sight. I am trying to lean out but hold onto my muscle gains.

FHG
 
I take it 30min. before a meal. If i take it after a meal i will soon be hungry again, so to prevent that i take it before.

I would advise against taking it w/ your post workout shake however, i think it's working against what you want in this type of situation. If you take ALA before your preworkout meal i found it works great.

good luck bro...
 
I always thought ALA should be used post cycle to help shuttle the simple post workout carbs into your muscles? How does it not help that? Also, Kilosports has pretty good prices on ALA, and from my experiences, is good quality too.
 
drgreenhill i would agree w/ you w/ all prohormones except 1AD. This supplement does actually work, and my strength is steadlily climbing w/ it. I've gained 11 pounds and i'm on my 15th day. That's excellent IMO.

cozmok i would agree w/ you it does speed up the process a bit by lowering your blood sugar.

Growin, I'm not entirely sure on the mechanism of action of ALA. But i would not use it post workout b/c post workout you want that insulin spike and ALA will decrease the insulin spike. This goes against what you want. I'd take your postworkout shake just as it is, make sure you have at least 50g of dextrose or maltodextrin in there for the spike though.
 
I have found that taking alpha lipoic acid before your workout will give you crazy pumps, but it will make yiou very sluggish and dizzy and I only take it post workout and it works great, but I spoke to some people who love to take it pre workout as oposed to post workout. Whatever works best for you I guess.
 
A while back, I was having ALA about 3-4 times a week because it was in the Nitro-Tech Bars I eating. Well, that is some potent shit, or maybe it is just me? because I am very suseptible to hypoglycemic episodes. I couldn't go more than 60-90 minutes after my post-workout meal without eating unless I would start to feel tremors and signs of a very low blood sugar level.

I would love to take this supplement because I have heard so many great things about it, but it probably would not be a good idea if it causes hypoglycemic episodes. Any suggestions?
 
Last edited:
See a lot of people didn't believe me that it can make you hypoglycemic, but i know that's one of its effects. I still wouldn't take it post workout w/ the 1st post workout shake. Before is better IMO but i'm no expert and i could be wrong. But you do need to eat w/ ALA, that's why i take it 30min. before a meal, you don't want do be hypoglycemic or have any of the reactions of hypoglycemia.
 
From what I remember, I wasn't even eating the bars(with ALA) anytime near my postworkout meal. I think the effect of ALA must be pretty long lasting? at least a day, if not more? I emailed muscletech.com asking how much ALA is in each bar, but never got a response.

Recently, when I was using dexedrine, it also changed my blood sugar levels, causing me to be suseptible to go hypo.Whenever I take shit that causes hypoglycemic episodes, I either gotta eat constantly, which will accumulate to be 4000-5000 calories in a day, or go Hypo and then I will eat like 2000 calories in one meal. Either way I end up eating ALOT more(like 1500 calories more per day) when I'm on a substance that can cause hypoglycemic episodes.

Last night, I ate the whole container of planters macademia nuts. Thats about 160 grams of fat in one sitting and then I had 80-90 grams of protein from whey and casein powders. I'm lucky I ate immediatly as I felt the episode coming because if I were to wait as little as 10 minutes longer then I would have had to eat high GI carbs. At that point, Protein or fat would not do much. In fact, I would have only had the appetite to eat 500 calories or so, at that point. One minute(when I ate, I felt like eating 2000 calories, and I did.), then if I would have waited 10 -20 minutes, I would have really had no appetite, but I would be shaking and dizzy as hell.
 
Last edited:
hey bro what you're experiencing is not normal. You may need to get checked out or have the doc check your blood sugar levels b/c that's not normal. The ALA as far as i know, i feel the effects in about half an hour, but they don't last much longer than that b/c i eat afterwards.

and Drgreenhill, i PMed you back but your mailbox is full.
 
riskybizz007 said:
drgreenhill i would agree w/ you w/ all prohormones except 1AD. This supplement does actually work, and my strength is steadlily climbing w/ it. I've gained 11 pounds and i'm on my 15th day. That's excellent IMO.

cozmok i would agree w/ you it does speed up the process a bit by lowering your blood sugar.

Growin, I'm not entirely sure on the mechanism of action of ALA. But i would not use it post workout b/c post workout you want that insulin spike and ALA will decrease the insulin spike. This goes against what you want. I'd take your postworkout shake just as it is, make sure you have at least 50g of dextrose or maltodextrin in there for the spike though.
Click to expand...

Nope. ALA has ZERO effect on blood insulin levels.
It does NOT degrade insulin at all, it just increases
blood glucose up-take and clearance.

It does this by increasing the number of glut-4 transporters
on the out-side of the cell, therefore increasing the cells ability
to soak up glucose.

This is how it works....

Post-Wo meal:

Take your usual High-GI carbs + protein,
then lets see what happens with ALA and w/o
ALA.


W/o ALA, your food intake will create an insulin surge from the
pancreas and this surge will shuttle the nutrients you have just
ingested into your cells.

BUT, these would be BOTH your FAT and MUSCLE cells.

W/ALA, your food intake will create an insulin surge from the
pancreas and this surge will shuttle the nutrients you have just
ingested into your cells.

However, ALA has MARKEDLY increased your muscle-cells
Glut-4 content therfore it has a greater ability to soak up
glucose.

So what happens, MORE of the nutrients are diverted to your
muscle cells INSTEAD of your fat cells, yet INSULIN LEVELS
REMAIN UN-CHANGED!!!

What this means is that you have created a nutrient-partitioning
effect which will give you more muscle gain/less fat gain in the
long run.


And to the first poster, ALA prevents oxidative damage, which
is one of the reasons why MDMA is neuro-toxic(it increases
free-redical production dramatically). That is why ALA works
in this case, It is the best free-radical scavenger out there
since it is both fat and watwer soluble.

Fonz
 
Good reply Fonz. Don't see you around here much, You mostly at AF? I have been taking 1000mg of ALA a day with 3-400 of that with my PW meal which consists of 120g dextrose and 60g Whey/BCAA/GLutamine. The rest of the ALA is spread evenly throughout the day with meals. Does that sound about right?
 
Fonz thanks for that very informative post. I know ALA increases blood glucose uptake, and you mentioned that it has no effect on insulin levels. If this were true why do so many people feel hypoglycemic w/ ALA, me included. I felt that it lowered blood glucose levels. I know when i take it I start to feel hypoglycemic, and more than anything i get really hungry w/ it at times even if taken after a big meal.
 
growin' said:
Good reply Fonz. Don't see you around here much, You mostly at AF? I have been taking 1000mg of ALA a day with 3-400 of that with my PW meal which consists of 120g dextrose and 60g Whey/BCAA/GLutamine. The rest of the ALA is spread evenly throughout the day with meals. Does that sound about right?
Click to expand...

At AF? No, not really. I've posted maybe 10-12 posts since
Animal got banned(Which I disagreed with). Just been
around at a female board b/c they needed some advice with
their supplements. Thats pretty much it. I post on the A board every once in a while when a perticulalrly good topic pops up.

And your ALA dosing scheme look A-OK.

Fonz
 
Animal was banned? Damn, I missed that one. What happened, if you don't mind posting. Was he too opinionated? HEHE
 
growin' said:
Animal was banned? Damn, I missed that one. What happened, if you don't mind posting. Was he too opinionated? HEHE
Click to expand...

He disagreed with the MODS there about a perticular
idea they had. i.e. Animal told them they were flat out
wrong in his own charming, charismatic way...... :)
And then, they banned him. Which I strongly
disagreed with. But, there was really nothing to be
done. There's 3 MODS there that think they're
always right and can't bear to be told they flat out
aren't. Actually, i'm amazed I wasn't banned too because
I always clash with their ideas.

Fonz
 
Fonz said:


Nope. ALA has ZERO effect on blood insulin levels.
It does NOT degrade insulin at all, it just increases
blood glucose up-take and clearance.

It does this by increasing the number of glut-4 transporters
on the out-side of the cell, therefore increasing the cells ability
to soak up glucose.

This is how it works....

Post-Wo meal:

Take your usual High-GI carbs + protein,
then lets see what happens with ALA and w/o
ALA.


W/o ALA, your food intake will create an insulin surge from the
pancreas and this surge will shuttle the nutrients you have just
ingested into your cells.

BUT, these would be BOTH your FAT and MUSCLE cells.

W/ALA, your food intake will create an insulin surge from the
pancreas and this surge will shuttle the nutrients you have just
ingested into your cells.

However, ALA has MARKEDLY increased your muscle-cells
Glut-4 content therfore it has a greater ability to soak up
glucose.

So what happens, MORE of the nutrients are diverted to your
muscle cells INSTEAD of your fat cells, yet INSULIN LEVELS
REMAIN UN-CHANGED!!!

What this means is that you have created a nutrient-partitioning
effect which will give you more muscle gain/less fat gain in the
long run.


And to the first poster, ALA prevents oxidative damage, which
is one of the reasons why MDMA is neuro-toxic(it increases
free-redical production dramatically). That is why ALA works
in this case, It is the best free-radical scavenger out there
since it is both fat and watwer soluble.

Fonz
Click to expand...

So Fonz, what kinda milligramage should we all be takin'? I just got some Jarrows ALA. And I should take the full daily dosage with my post workout meal?

FHG
 
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