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[GUARDIAN]

pwned

J Nutr. 2007 Jun;137(6):1621S-5S. Links
Citrulline: a new player in the control of nitrogen homeostasis.

Moinard C,
Cynober L.
Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, France and 5Laboratoire Biochimie, Hotel-Dieu, AP-HP, Paris 75004, France.
Citrulline (CIT) is an amino acid that is not involved in protein synthesis but that is tightly linked to arginine (ARG) metabolism. CIT displays a very specific metabolism: In the 1980s, Windmuller demonstrated that the small intestine releases CIT, which is mainly taken up by the kidney and metabolized into ARG. Because CIT is not taken up by the liver, this ARG-CIT-ARG cycle can be seen as a means of protecting dietary ARG from liver degradation and of sustaining protein homeostasis. These observations have led to the concept that plasma CIT concentration would be a good marker of intestinal failure in short bowel syndrome. Hence, in massive intestinal resection, citrullinemia is greatly reduced, and this is proportional to the severity of the intestinal disease. This concept was then extended to other situations in which the intestinal function is compromised. The data strongly suggest that CIT may be a conditionally essential amino acid in situations where the intestinal function is compromised. Recent data support this idea. Thus, CIT supplementation is able to restore nitrogen balance, generate large amounts of ARG in rats with short bowel syndrome, and increase muscle protein content (+20%) as well as muscle protein synthesis (+90%) in elderly malnourished rats. Finally, recent data indicate that CIT per se could be able to stimulate muscle protein synthesis. Hence, CIT could play a pivotal role in maintaining protein homeostasis, and the determination of the underlying mechanisms involved in its action should be important for the development of new nutritional strategies in malnourished patients with compromised intestinal functions.
PMID: 17513438 [PubMed - in process]

 

[Big Rick Rock]

Tatyana is putting a lot of effort into discrediting Ross... Disturbing.

 

[Ross]

Tat, what is your point, you simply posted studies demonstrating the EFFECTIVENESS of Citrulline, which is contained in Obol...

 

[Tatyana]

Tatyana is putting a lot of effort into discrediting Ross... Disturbing.

Not really that much effort.

I read a lot, and I have a funny memory that I remember odd bits about certain supps and compounds.

Also, it's part of my job to critically evaluate scientific papers.

So when someone is claiming that a supp is the newest and greatest thing, but the papers are close to thirty years old (and Russian obscure papers), little warning bells go off.

 

[Ross]

Not really that much effort.

I read a lot, and I have a funny memory that I remember odd bits about certain supps and compounds.

Also, it's part of my job to critically evaluate scientific papers.

So when someone is claiming that a supp is the newest and greatest thing, but the papers are close to thirty years old (and Russian obscure papers), little warning bells go off.

It doesn't matter how OLD the studies are Tat, the studies are VALID.

 

[Big Rick Rock]

Not really that much effort.

I read a lot, and I have a funny memory that I remember odd bits about certain supps and compounds.

Also, it's part of my job to critically evaluate scientific papers.

So when someone is claiming that a supp is the newest and greatest thing, but the papers are close to thirty years old (and Russian obscure papers), little warning bells go off.

The steroid I took this morning was designed over 60 years ago ! !

 

[Ross]

The steroid I took this morning was designed over 60 years ago ! !

LOL!! ME TOO BROTHA!!!

 

[Tatyana]

It doesn't matter how OLD the studies are Tat, the studies are VALID.

According to the latest one, they aren't as they were not able to get enough of the method/data from them to reproduce the same experiments.

 

[Tatyana]

The steroid I took this morning was designed over 60 years ago ! !

So was penicillin.

That wasn't the issue I was addressing.

There is old research that is valid and will never be repeated, for example, there is a great study from the 1920s or 30s where they weighed rabbits and all their organs and glands, or when they took blood samples from people in the 1960s every hour on the hour to determine fluctuations in various analytes.

I am also right now trying to get my hands on a 1973 paper about a method for precipitating immunoglobulins, the first time it was described.

With regards to the last paper, this is the rub, it was the FIRST time it was described, the method is solid, and it is used ALL the time, just with tweaks for various analytes.

Some older research papers are not of any clinical or research value, and I assert the papers Ross has been citing are in that vein.

I have over 10 years of doing this sort of scientific literacy, and three science degrees.

I do have an idea of what I am talking about.

 

[Big Rick Rock]

So was penicillin.

That wasn't the issue I was addressing.

There is old research that is valid and will never be repeated, for example, there is a great study from the 1920s or 30s where they weighed rabbits and all their organs and glands, or when they took blood samples from people in the 1960s every hour on the hour to determine fluctuations in various analytes.

I am also right now trying to get my hands on a 1973 paper about a method for precipitating immunoglobulins, the first time it was described.

With regards to the last paper, this is the rub, it was the FIRST time it was described, the method is solid, and it is used ALL the time, just with tweaks for various analytes.

Some older research papers are not of any clinical or research value, and I assert the papers Ross has been citing are in that vein.

I have over 10 years of doing this sort of scientific literacy, and three science degrees.

I do have an idea of what I am talking about.

Tatyana... Forgetting about these research papers for a minute (many of which can be wrong. A lot actually)

You have been around this industry for a while... What do you think about Citrulline Malate in Bodybuilding formulas? I mean ALL formulas. Because Ross is not the only one putting the stuff in a capsule... You visit other forums and read people's reviews on products. What have other bodybuilders been saying about it???

I know Mavafanculo thinks is a great product. He suggested it to me recently for something I was researching...

What do you think about the actual use of it?