GHRP-6 and CJC-1295 Usage

[LaxPro]

Hey guys,

I'm extremely new to peptide use and recently just started taking IGF-1 LR3 but I've heard that if you wanted to see real results that I should take GHRP-6 and CJC-1295. I've searched so many places to see how to use it properly but I havent been able to find anything relatively useful.

Can anyone help me and give me some good information on how to use these two, more specifically regarding dosage, when to pin, storage, etc.

Thanks

 

[infraredline]

Hey guys,

I'm extremely new to peptide use and recently just started taking IGF-1 LR3 but I've heard that if you wanted to see real results that I should take GHRP-6 and CJC-1295. I've searched so many places to see how to use it properly but I havent been able to find anything relatively useful.

Can anyone help me and give me some good information on how to use these two, more specifically regarding dosage, when to pin, storage, etc.

Thanks

- Dosage is 1mcg per kg of body weight
- dose 3x daily (first thing in morning, post workout, pre-bed)
- wait 30 minutes to eat after dosing and eat your fats last
- give at least 2 hours between doses
- get 1cc slin pins for reconstitution
- get .3 or .5cc slin pins for injection. I always got 29 or 30 gauge needles
- reconstitute with bacteriostatic water or .09 sodium chloride
- store in the fridge
- only reconstitute 1 ipamorelin and 1 cjc no DAC at a time
- use peptidecalculator.com to calculate out everything

Also you are going to want ipamorelin and cjc no DAC

 

[LaxPro]

Alright that's very helpful thanks, just two more questions.

Why do you recommend taking ipamorelin and CJC no DAC?
Do I take 1mcg per Kg of body weight each dosage or spread it out through out the day?

Thanks Again

 

[infraredline]

Alright that's very helpful thanks, just two more questions.

Why do you recommend taking ipamorelin and CJC no DAC?
Do I take 1mcg per Kg of body weight each dosage or spread it out through out the day?

Thanks Again

Ipamorelin because it doesn't come with the water retention you will get from ghrp-2 or 6

Cjc no DAC because you want your gh to pulse, not bleed

Yes 1mcg per kg of each

 

[Captain FT]

Some companies try to sell CJC without DAC as mod GRF 1-29 when in fact they are different - I'll dig up the reading.

You want:
mod GRF 1-29
And
Either GHRP-2, GHRP-6, or Ipamorelin.

Some have more pronounced effect on people than others, remember everyone is different. Ipamorelin tends to be the safest but also more expensive

Also, IGF-1 doesn't do anything for as far as exercise induced hypertrophy so don't spend any more money on that - in fact save it for if you injure yourself it may help with injury recovery.

 

[Mustang-73]

It's a great stack, although I used GHRP-2 as GHRP-6 increases your apetite greatly, I gradually increased pinning GHRP-2 to 3 times a day (half an hour before breakfast, lunch and after dinner), need to monitor your carb intake (although that's what I was told). CJC I would take before bed. Infraredline is spot on.

 

[Captain FT]

Here is the reading I was looking for on CJC and GRF 1-29. All credit goes to Datbtrue of the Datbtrue forum, those guys are a wealth of knowledge on peptides and after reading many many many posts over there did i dive into peptides and then eventually felt comfortable with HGH once i knew enough.

Now keep in mind this was from 2011 and things may have changed since then, but I never bought anything that said CJC1295 w/o DAC, what i purchased for my first run was called mod GRF 1-29.

Growth Hormone Releasing Hormone (GHRH) which is the native hormone binds to a receptor on a somatotroph (which is a cell in the anterior pituitary which makes & stored Growth Hormone (GH) (the 20 & 22kda forms and stacks of those two form and fragments). When GHRH binds to a GHRH receptor on a somatotroph in the anterior pituitary it causes GH release.

Actually the somatotrophs form a cell population and they communicate and coordinate a GH release. They actually communicate and try (it is easy to do in youth) to release a concentrated GH into nearby veins so that you get a nice dense concentration which will form a nice pulse. I think of it as a squid releasing ink in the water... it is concentrated. Unfortunately as we age the somatroph population is not as good at coordinating a release and the GH release is less dense. I think of it as a kid moving around a big pool while urinating. See somatroph population in action: ADVANCED TOPIC - Pulsation

GHRH is a 44 amino acid peptide. It binds to its native receptor on the membrane of somatrophs and brings about GH release. See the link I gave earlier. [To be very, very complete sometimes GHRH shows up as a 40 amino acid peptide]

Now the final 15 amino acids of GHRH are unnecessary to bind and activate the GHRH receptor, so in the lab they have been left off and only the first 29 are kept. This was named GRF(1-29). This stands for Growth Hormone Releasing Factor and the 1-29 means amino acids from position 1 to 29 of GHRH were retained.

GRF(1-29) was named Sermorelin by a pharmaceutical company. GRF(1-29) binds to the GHRH receptor as well as GHRH does.

Now if you inject GRF(1-29) into the blood streams enzymes will quickly cleave the peptide at the 2nd position. So GRF(1-29) was altered at the 2nd position to prevent this. That alteration was replacing alanine with its isomer D-alanine. D-Ala2 GRF(1-29) binds to the GHRH receptor as well as GHRH does.

Now to make GRF(1-29) even more resilient 3 more amino acids were changed, brining the total changes to four (tetra - the Greek cardinal number 4). So a tetra subbed GRF(1-29) is GRF(1-29) with replacements at the 2nd, 8th, 15th & 27th amino acids positions. This also has come to be known as "Modified GRF(1-29)". Modified GRF(1-29) binds to the GHRH receptor as well as GHRH does.

Now a company called ConjuChem Biotechnologies Inc. came up with a drug. A drug called a "drug affinity complex" (DAC). This complex attaches to albumin in plasma. So they experimented with it by attaching it to insulin and glucagon-like peptide-1. Those were there two primary products. Along the way they also experimented with attaching it to various forms of GRF(1-29). They attached it to an added lysine (called a linker) which was attached to GRF(1-29) and called this CJC (after ConjuChem) plus the number 1288 (CJC-1288) to compare with attaching it to an added lysine (called a linker) which was attached to D-Ala2 GRF(1-29) which was called CJC-1293 to compare with attaching it to an added lysine (called a linker) which was attached to Modified GRF(1-29) which was called CJC-1295.

All of these Drugs (CJC-1288, CJC-1293, CJC-1295) binds to the GHRH receptor as well as GHRH does. ConjuChem Biotechnologies Inc. stopped experimenting clinically after a member of the study group died. ConjuChem Biotechnologies Inc. also saw the worthlessness of this product and focused on the insulin and GLP-1 product (called Exendin-4).

Unfortunately ConjuChem Biotechnologies Inc's product (drug affinity complex) had no commercial value. They filed for bankruptcy on 7/21/2010 in Canada under the Bankruptcy and Insolvency Act.

Now the banner ad retailers somehow all where lied to by the Chinese and years ago were selling CJC-1295 however it was not CJC-1295. It usually was plain old GRF(1-29). When they were called on it they created phony COAs for customers. However in my original thread you can see that years ago we came to understand that CJC-1295 results in growth hormone bleed. You don't actually bleed (I saw someone educate another on some board once where they said CJC causes bleeding ). What happens is you elevate troughs and the trough to peak pulsation is of reduced amplitude... and you end up with GH oozing out in more "urinating in the pool" fashion as opposed to the "squid ink" more desirable pattern.

So years ago we determined that CJC-1295 was not desirable but modified GRF(1-29) was desirable. The banner ad retailers after the early rounds of lying eventually made demands of their Chinese suppliers and they eventually produced some CJC-1295. So that is what they sold. The CJC to them was a premium label so when people demanded that they sell them something useful they just attached the CJC moniker to everything. They then threw in the "w/o DAC". Then they got really confused and started with CJC-1293 w/o DAC. They never realize that CJC-1293 would indicate that they have only that one modification at the 2nd position D-Ala2 GRF(1-29) + lysine + DAC.

When they through in the term "w/o DAC" they are indicating that they are selling D-Ala2 GRF(1-29) + an unstable lysine.

 

[LaxPro]

All this info is great thanks a lot guys. I just want to mention that I've been using IGF-1 for about a month now and have seen unbelievable results for strength and a little bit of a gain size wise, but it is extremely expensive and can't keep affording it. I looked at us peptides and they sell straight up CJC-1295 for relatively cheap and ipamorelin for extremely cheap. Again thanks for all the info it will be extremely helpful when I go to buy these products and actually use then

 

[LaxPro]

I forgot to ask how much do I add of the bacteriostatic water to the ipamorelin and cjc

 

[infraredline]

Depends on how concentrated you want it.

Use this website to figure out how much you want to use:
http://peptidecalculator.com/calculator.php