GH and The Athlete - is there a point to it???

[Juice Authority]

Let's stick this for a bit.

Thanks genarr. It would be good to hear some feedback from ironmaster and others on this topic.

 

[alanchiras]

The people treating the HIV+ community are in general agreement. The third edition of 'Built to Survive' Does not have many kind words to say about GH and that the discussion takes away from the need of doctors to write more scripts for Test and AAS which clearly work. Thanks! Alan.

 

[genarr3]

Thanks genarr. It would be good to hear some feedback from ironmaster and others on this topic.

You're going to have to PM or email if you want his opionion.

 

[Juice Authority]

You're going to have to PM or email if you want his opionion.

Yeah I just did. Hopefully he'll be able to shed some light on this.

 

[DrJMW]

Doc, I follow what you're saying here but many people are still under the false assumption that GH builds muscle mass when it clearly does not. Also, there are much less expensive alternatives to fat burning than GH. GH as you know is not cheap. Even the black market GH is rather expensive when used in the context of "leaning out". T3, clen, metabolic stimulates and even foods rich in medium-chain triglycerides (MCTs) have all have been shown to decrease adipose tissue at obviously at much lower cost. What is the point of using GH if you're under 30 yrs old? It seems like GH would make much more sense for someone who's in his late 30's and up since it has been shown that there is a progressive decline in GH secretion from the pituitary after the age of 30. I continually see young guys in their late teens to early 20's using GH, which would only suppress their GH/IGF-1 axis. Any comments on this?

HGH directly stimulates beta-3 receptors which makes it the superior fat burner. There is no other compound that does so. T3 burns everything, not just fat. Clen is a beta-2 receptor agonist, so its effects are indirect. Those overweight and young should be able to "cut" without HGH. Those obese and older cannot do it with diet, training, and supps alone. It is foolish for teens and young 20's to use HGH, for their levels are still high. So, I do agree with the sense of your post, JA.

 

[majutsu]

The reviews on GH, like the latest one in British Journal of Medicine "A Case of the Emperor's New Clothes . . . ", all lean like this JA. In terms of muscular, medical applications (e.g. dystrophies, AIDS wasting syndrome, etc), results have been poor indeed. Fat loss, especially when coupled with exogenous thyroid is definite and proven. There is a study, by the same group as yours (!), showing a small, but significant synergy (a small effect size) with AAS. That's about it: couple it with T3 for a great fat loss stack, or couple it with an AAS for mass. Does it have use for the athlete? Yes, the two uses above . . . Is it worth the cost? Depends on your level (if 2-3 g of AAS ew doesn't touch you anymore, GH will get the growth going again) or how rich you are (maybe you use growth, anavar and primo just to show off how rich you are ), or both. Nice thread.

 

[DrJMW]

This was one of the best discussions I've seen in a long time here at EF. Thanks for all of the input.

 

[Juice Authority]

The reviews on GH, like the latest one in British Journal of Medicine "A Case of the Emperor's New Clothes . . . ", all lean like this JA. In terms of muscular, medical applications (e.g. dystrophies, AIDS wasting syndrome, etc), results have been poor indeed. Fat loss, especially when coupled with exogenous thyroid is definite and proven. There is a study, by the same group as yours (!), showing a small, but significant synergy (a small effect size) with AAS. That's about it: couple it with T3 for a great fat loss stack, or couple it with an AAS for mass. Does it have use for the athlete? Yes, the two uses above . . . Is it worth the cost? Depends on your level (if 2-3 g of AAS ew doesn't touch you anymore, GH will get the growth going again) or how rich you are (maybe you use growth, anavar and primo just to show off how rich you are ), or both. Nice thread.

Agreed.

BTW, what did you think of the hyperplasia article?

 

[drveejay11]

AWESOME subject JA/good stuff bro

 

[Juice Authority]

HGH directly stimulates beta-3 receptors which makes it the superior fat burner. There is no other compound that does so. T3 burns everything, not just fat. Clen is a beta-2 receptor agonist, so its effects are indirect. Those overweight and young should be able to "cut" without HGH. Those obese and older cannot do it with diet, training, and supps alone. It is foolish for teens and young 20's to use HGH, for their levels are still high. So, I do agree with the sense of your post, JA.

Interesting. The following study expands on this a little more since they were testing specifically for GH's action on the beta-3 receptor. I have a question though. If GH is not mediated through the beta-3 receptor how exactly does it increase repressed levels of beta-3?

Endocrinology. 2001 Dec;142(12):5182-9. Related Articles, Links


The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.

Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia 3800.

Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity following long-term treatment in mice. One mechanism by which this may occur is through an interaction with the beta-adrenergic pathway, particularly with the beta(3)-adrenergic receptors (beta(3)-AR). Here we describe how hGH and AOD9604 can reduce body weight and body fat in obese mice following 14 d of chronic ip administration. These results correlate with increases in the level of expression of beta(3)-AR RNA, the major lipolytic receptor found in fat cells. Importantly, both hGH and AOD9604 are capable of increasing the repressed levels of beta(3)-AR RNA in obese mice to levels comparable with those in lean mice. The importance of beta(3)-AR was verified when long-term treatment with hGH and AOD9604 in beta(3)-AR knock-out mice failed to produce the change in body weight and increase in lipolysis that was observed in wild-type control mice. However, in an acute experiment, AOD9604 was capable of increasing energy expenditure and fat oxidation in the beta(3)-AR knock-out mice. In conclusion, this study demonstrates that the lipolytic actions of both hGH and AOD9604 are not mediated directly through the beta(3)-AR although both compounds increase beta(3)-AR expression, which may subsequently contribute to enhanced lipolytic sensitivity.

PMID: 11713213 [PubMed - indexed for MEDLINE]