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Yasmin
- Thread starter wilson6
- Start date
From the January 2003 issue of CONTRACEPTION:
Effect of four different oral contraceptives on various sex hormones and serum-binding globulins
..................The 40–60% reduction in the serum concentrations of free testosterone was observed with the four formulations in the first cycle of intake and remained in this range
during further treatment. The effect is similar to that reported for various OCs irrespective of their composition [17, 18 and 21]. The level of free testosterone, which
is suggested to be the biologically active fraction of circulating testosterone, is influenced by the concentration of total testosterone and SHBG, which binds a large
proportion of the androgen with high affinity [27]. The suppression of total testosterone by 30–40%, which has been observed during treatment with many OCs [15,
16, 17, 18, 19, 28, 29 and 30], was suggested to be caused by both a reduction of gonadotropin release and a rapid direct inhibitory effect of sex steroids on
ovarian and adrenal steroid synthesis [31, 32 and 33]. The corresponding reduction of free testosterone levels is enhanced by the EE-induced rise in SHBG [27]..................
There's a lot more too. But basically taking ANY oral contraceptive is really shooting yourself in the foot by both decreasing total production of testosterone AND dramatically increasing SHBG.
Control of your reproduction is naturally up to you. But I can't fathom why any serious female BB would contemplate taking this stuff either while dieting or mass gain phases. There are other options, and 'convenience' is one of those words that really good bodybuilders should be wary of. If BB were convenient then everyone would do it. Likewise you may have to put some time, research and a little bit of effort into your birth control program if you want optimal natural hormone levels for muscle growth/fat loss.
Effect of four different oral contraceptives on various sex hormones and serum-binding globulins
..................The 40–60% reduction in the serum concentrations of free testosterone was observed with the four formulations in the first cycle of intake and remained in this range
during further treatment. The effect is similar to that reported for various OCs irrespective of their composition [17, 18 and 21]. The level of free testosterone, which
is suggested to be the biologically active fraction of circulating testosterone, is influenced by the concentration of total testosterone and SHBG, which binds a large
proportion of the androgen with high affinity [27]. The suppression of total testosterone by 30–40%, which has been observed during treatment with many OCs [15,
16, 17, 18, 19, 28, 29 and 30], was suggested to be caused by both a reduction of gonadotropin release and a rapid direct inhibitory effect of sex steroids on
ovarian and adrenal steroid synthesis [31, 32 and 33]. The corresponding reduction of free testosterone levels is enhanced by the EE-induced rise in SHBG [27]..................
There's a lot more too. But basically taking ANY oral contraceptive is really shooting yourself in the foot by both decreasing total production of testosterone AND dramatically increasing SHBG.
Control of your reproduction is naturally up to you. But I can't fathom why any serious female BB would contemplate taking this stuff either while dieting or mass gain phases. There are other options, and 'convenience' is one of those words that really good bodybuilders should be wary of. If BB were convenient then everyone would do it. Likewise you may have to put some time, research and a little bit of effort into your birth control program if you want optimal natural hormone levels for muscle growth/fat loss.
JJFigure
New member
Damn, damn, and triple damn! Sometimes I get so frustrated with being a woman and having to put up with this estrogen mierda.
KBGrl - I spoke with my doctor about my reasons for not wanting to take Yasmin and she chose another pill for me, a generic form of Alesse. Of course, this was before MS posted that any oral contraceptive will decrease testosterone production. I like taking the pill mainly because it keeps my cycles regular, plus I really really don't want to get pregnant right now. Maybe dropping the pill and abstinence is the answer...now how do I break that to the guy I'm seeing?
We're doubling up w/ condoms and OC; I'm just really paranoid about getting pregnant and don't really trust condoms on their own.
KBGrl - I spoke with my doctor about my reasons for not wanting to take Yasmin and she chose another pill for me, a generic form of Alesse. Of course, this was before MS posted that any oral contraceptive will decrease testosterone production. I like taking the pill mainly because it keeps my cycles regular, plus I really really don't want to get pregnant right now. Maybe dropping the pill and abstinence is the answer...now how do I break that to the guy I'm seeing?
We're doubling up w/ condoms and OC; I'm just really paranoid about getting pregnant and don't really trust condoms on their own.JJ.. My cousin got pregnant while on bc. she was tld she had to raise the dose every couple of yrs. I didn't know that
I think if you didn't want to use the pill, using condoms and not havign sex when you're ovualting would be pretty safe. I need to use the pill or something else cause condoms... ugh. I hate the smell, taste and feeling BUT it's much better than an unwanted pregnancy.
I think if you didn't want to use the pill, using condoms and not havign sex when you're ovualting would be pretty safe. I need to use the pill or something else cause condoms... ugh. I hate the smell, taste and feeling BUT it's much better than an unwanted pregnancy.
JJFigure
New member
I found a little more information to back up MS's post:
Androgenicity
Third generation progestins such as desogestrel, and also norgestimate (technically a newer 2nd generation progestin) were developed and marketed as "less androgenic" progestins than older preparations
In fact, studies of androgenicity of progestins are based on rat models: binding of steroids to rat ventral prostate 9. These artificial rankings did not take into account dose adjustments, or the differential effect of steroid hormones on different target tissues in humans, and are not clinically meaningful. 1, 10
ALL COMBINATION OCs ARE ANTI-ANDROGENIC
OCs inhibit LH and thus decrease ovarian production of testosterone
Estrogen leads to increased sex hormone binding globulin (SHBG) production by liver, progestin decreases SHBG, but overall effect of OCs is to increase SHBG
3rd generation progestins increase SHBG more than monophasic older preparations 11
Increased SHBG leads to decrease in free testosterone
3rd generation progestins compete less for binding with SHBG
Progestin mediated inhibition of 5-a reductase leads to decreased DHT
Formation of DHT necessary for any cellular effects on skin/hair follicles 12
Thus all OCs should help treat acne & hirsutism, although some suggestion that 3rd generation pills (containing desogetsrel, norgestimate) may be of more benefit (this is not clinically proven though).
RCT of ethinyl estradiol-norgestimate (Ortho-Tri Cyclen) showed greater improvement in acne after 6 mo of therapy in treatment group compared to placebo (83% vs. 62%), although both groups showed improvement compared to baseline 13
Similar response rate to women using topical agents (benzoyl peroxide, tretinoin) or systemic antibiotics
I found this at the following website, in case anyone wants to read more:
http://www.med.umich.edu/obgyn/resdir/contraception/OralContLalley.htm
Androgenicity
Third generation progestins such as desogestrel, and also norgestimate (technically a newer 2nd generation progestin) were developed and marketed as "less androgenic" progestins than older preparations
In fact, studies of androgenicity of progestins are based on rat models: binding of steroids to rat ventral prostate 9. These artificial rankings did not take into account dose adjustments, or the differential effect of steroid hormones on different target tissues in humans, and are not clinically meaningful. 1, 10
ALL COMBINATION OCs ARE ANTI-ANDROGENIC
OCs inhibit LH and thus decrease ovarian production of testosterone
Estrogen leads to increased sex hormone binding globulin (SHBG) production by liver, progestin decreases SHBG, but overall effect of OCs is to increase SHBG
3rd generation progestins increase SHBG more than monophasic older preparations 11
Increased SHBG leads to decrease in free testosterone
3rd generation progestins compete less for binding with SHBG
Progestin mediated inhibition of 5-a reductase leads to decreased DHT
Formation of DHT necessary for any cellular effects on skin/hair follicles 12
Thus all OCs should help treat acne & hirsutism, although some suggestion that 3rd generation pills (containing desogetsrel, norgestimate) may be of more benefit (this is not clinically proven though).
RCT of ethinyl estradiol-norgestimate (Ortho-Tri Cyclen) showed greater improvement in acne after 6 mo of therapy in treatment group compared to placebo (83% vs. 62%), although both groups showed improvement compared to baseline 13
Similar response rate to women using topical agents (benzoyl peroxide, tretinoin) or systemic antibiotics
I found this at the following website, in case anyone wants to read more:
http://www.med.umich.edu/obgyn/resdir/contraception/OralContLalley.htm
Glad you're not gonna shoot the messenger 
It is irrelevant to 99.999% of women out there, but any OC that reduces their acne is, by definition, reducing their test levels. JJ, perhaps you could mention to your partner that OCs, by reducing free T, may also reduce sex drive and that going OFF the OCs may increase it. Maybe THAT would motivate him to help find alternative, male initiated, methods of birth control!!!! Not that you could ever completely trust a male with anything short of castration, but there are alternatives for both of you..........
It is irrelevant to 99.999% of women out there, but any OC that reduces their acne is, by definition, reducing their test levels. JJ, perhaps you could mention to your partner that OCs, by reducing free T, may also reduce sex drive and that going OFF the OCs may increase it. Maybe THAT would motivate him to help find alternative, male initiated, methods of birth control!!!! Not that you could ever completely trust a male with anything short of castration, but there are alternatives for both of you..........
The Mirena IUS is like many other types of Intrauterine Contraceptive Devices (IUCD's or coils) in that it is fitted by a doctor
and remains in the womb for a fixed amount of time, after which it must be changed. It is different, however, in that it is
much more effective than usual IUCD's and avoids many of the side effects that put women off this choice of contraception.
In this review the abbreviation IUCD refers to this whole group of contraceptives,
and the terms Mirena and IUS will be used interchangeably.
Most IUCD's make a woman's periods heavier, but the Mirena actually makes
periods lighter than usual. Because of this, it is frequently used as a treatment for
heavy periods, even in women who don't need contraception. As can be seen in
the picture, it is made of a light, plastic, T-shaped frame with the stem of the 'T' a
bit thicker than the rest. This stem contains a tiny storage system of a hormone
called Levonorgestrel. This hormone is also used in contraceptive pills such as
Eugynon, Logynon, Microgynon, Ovran 30, Ovranette and Trinordial. In the Mirena,
however, a much lower dose is released than when you take the Pill (about 1/7th
strength), and it goes directly to the lining of the womb, rather than through the
blood stream where it may lead to the common progesterone-type side effects (see below).
How effective is the contraception?
If 1000 women used the Mirena IUS for a year, only one would fall pregnant. This compares with about 10 for the normal
IUCD, 20 for the Pill and 10-15 for the injection (Depot Provera). This is comparable to the effectiveness of sterilisation.
Mirena acts as a contraceptive in two ways: it makes the mucus at the neck of the womb (the cervix) much thicker,
preventing sperm from getting through and it also makes the lining of the womb extremely thin, stopping implantation. In
some women it prevents egg release (ovulation).
As with all IUCD's, if it does fail, there is a higher risk of ectopic pregnancy (a pregnancy located outside the womb, usually
in the tube). If you felt pregnant or had a positive pregnancy test, it is important to see your doctor to rule this out. Overall,
however, compared to women not using any contraception, the risk of ectopic pregnancy is greatly reduced (around 2 per
10,000 women each year [1]) because the IUS is such a good contraceptive.
If a pregnancy does occur with an IUCD, it is advisable to remove the contraceptive if possible - this reduces the risk of
bleeding, infection and miscarriage. Because failure is so rare, there is little information available on the effects on an
ongoing pregnancy with the Mirena still in place.
Fitting the Mirena IUS
Before it is inserted, the doctor will do an examination to make sure the womb is a normal size and there is nothing else
unusual to find. If there is some discharge, swabs will be taken to rule out infection before it is placed. The IUS is inserted
within a week of beginning a period - this helps to reduce the chance of expulsion and irregular bleeding (as the womb lining
is already quite thin at this time). It may be inserted immediately after surgical termination of pregnancy, but should be
deferred until 6 weeks after delivery of a baby.
A speculum is placed in the vagina, like when you have a normal smear test, and the Mirena is placed into the womb
through the cervix. Because it contains the storage of hormone, the stem is slightly wider than in normal IUCD's. This can
occasionally lead to difficulties with fitting, especially if you have not had a baby before. In this situation, it would be helpful
to use some local anaesthetic. It should be fitted by someone who has been trained and has experience in fitting IUCD's.
It is a good idea to take some painkillers a couple of hours before the fitting - this will help reduce any discomfort. A good
choice is Ibuprofen 400 mg, which can be bought over-the-counter at a chemist (please check that this is safe for you).
Most women do not find the insertion procedure very uncomfortable - usually much less than expected.
Once the IUS is in place, you won't be able to 'feel' it in your womb. Your doctor will show you how to check for the strings,
and it is very unusual for your partner to be aware of it during intercourse. After fitting, a further appointment should be made
for six weeks later to check the strings can still be seen. Yearly checks are advised after this appointment.
Removing or changing the Mirena
Removal involves a speculum examination again and the IUS is removed by pulling on the strings. This is only
uncomfortable for a second or two as it comes out. The hormone effect on the lining of the womb is reversed within a month
and normal periods and fertility returns.
The IUS will last 5 years and, if required, a new one can be inserted at the same time the old one is removed.
Mirena for heavy periods
Although the IUS was originally developed as a contraceptive, the discovery that it leads to much lighter periods was a great
bonus. Many gynaecologists now suggest the Mirena as a treatment for heavy periods if tablet treatment doesn't work.
After 3 months use, the average blood loss is 85% less, and by 12 months the flow is reduced by 97% every cycle [2].
About one third of women using the IUS will not have any periods at all. Although women initially find it a bit unusual not
having periods, it doesn't cause any problems. There is no 'build up' of blood, because the hormone in the IUS prevents the
lining of the womb from building up at all. Often it is the excessive thickening of this lining that is the cause of the problems
in the first place.
One study looked at 54 women who had heavy periods and were awaiting hysterectomy [3]. They all used the Mirena, and
just under 70% were taken off the waiting list because they were happy with the treatment. In another study of 50 similar
women, 82% avoided major surgery [4].
The Mirena is now licensed for treating heavy periods, and although this official licensing is relatively new, it has been used
'off-license' for some time in this way.
Painful periods
Although the IUS isn't primarily used for painful periods, two studies [4,5] have found that it does help in many cases (as
often as 80% of the time). If painful periods persist, it is usual to rule out any other problems with a laparoscopy.
Fibroids
Large fibroids are a common cause of heavy periods. If they are so large, or in such a position that they make the inside of
the womb an abnormal shape, it is unlikely that the Mirena will remain in place, and would not be helpful as a treatment.
With small to moderate size fibroids, it is quite reasonable to use the IUS and one study [5] has found that fibroids are less
common in women who use the Mirena. A further paper has found that in the 5 women studied, a Mirena actually reduced
the size of their fibroids [6]. This is only one report, of course, and the IUS cannot be recommended as a treatment for
fibroids based on this alone, though it is very interesting.
Premenstrual syndrome (PMS)
PMS is a syndrome that is thought to be caused by the varying hormones of the menstrual cycle. There have been
suggestions that the IUS may be useful as it will allow a continuous dose of hormones to be given (oestrogen) without the
worry of excessive stimulation of the lining of the womb. Usually oestrogens are combined with a course of a progestagen to
prevent this, but many women experience PMS-like symptoms with progestagens. At present there is little published in the
medical literature about the use of the Mirena in this way, but for severe cases, where hysterectomy is being considered as
the only remaining alternative, it would certainly be reasonable to consider this.
Hormone replacement therapy (HRT)
There is a growing experience with the use of the IUS for women who require hormone replacement therapy, but who have
either bad PMS-like symptoms or erratic bleeding on normal HRT preparations. The IUS with continuous implants, tablets or
patches of oestrogen provides good symptom relief with minimal side effects. As its use in this way is not generally
established in the UK, this would normally be prescribed under the care of a gynaecologist. In other countries (eg. Finland)
the IUS is licensed for use in this way and can be routinely used for up to 5 years.
Ectopic pregnancy
Women who have experienced an ectopic pregnancy are at a greater risk of this happening again in future pregnancies. For
this reason, they are advised to choose a type of contraception that does not increase this risk any further - in particular
they are encouraged to avoid IUCD's, as these are known to increase this risk. The risk of ectopic pregnancy is very much
lower with the IUS than in women not using any contraception (60 times lower, in fact). Although perhaps not a first choice,
the IUS may be considered when other contraceptives are really not suitable. As with most decisions in medicine, it is
about the balance of risk.
Side effects
Expulsion. In the early months of use, there is a very small chance that the IUS may dislodge and come out, either in part
or altogether. This risk may be greater than with other IUCD's, presumably because it is that bit larger. There may be
symptoms such as bleeding or persistent pain not relieved by simple pain killers, or it might be passed without any
discomfort at all. As the system reduces blood flow, sudden return of heavy periods might suggest this has happened.
Hormonal problems. Although the IUS delivers its hormone directly to the lining of the womb, it does lead to a slight
increase in progesterone levels in the blood stream. The levels are much lower than that found with the progestagen-only pill
(POP) and usually don't lead to side effects. If they do occur, most often they are mild and only last up to 4-6 weeks. Side
effects have included headache, water retention, breast tenderness or acne.
Ovarian cysts. Progestagen hormones increase the chance of benign, simple ovarian cysts. This is more common with the
higher hormone levels associated with the progestagen-only pill. Overall the risk is about 3 times higher (1.2% in IUS users
versus 0.4% normally). These cysts most often do not require any treatment and resolve on their own over 2-3 months. It is
usual to arrange follow-up ultrasound scans over this time if they do occur. The most common symptoms of a cyst is
abdominal pain that doesn't settle with simple painkillers.
Bleeding problems. These are without a doubt the most common problem associated with the Mirena. It takes about 3
months for the lining of the womb to thin down and during this time bleeding can be erratic or even heavy at times, but
almost always settles after 3-6 months. During the first month, 20% of users experience prolonged bleeding of more than 8
days duration, but by the third month only 3% have prolonged bleeding.
Pelvic infection. In general IUCD's increase the risk of infection of the womb, tubes and other pelvic organs. Studies looking
at Mirena suggest that this may not be the case, with the IUS being protective against infection, particularly in the age
group most at risk (<25y). Although this would fit with the thickening of the cervical mucus preventing infection getting
through the cervix, this finding is not universal in all studies. The actual long-term risk of infection is very low, at less than
1% with 5 years' use. A World Health Organisation study of over 22,000 users found that the infection risk was only
increased in the first 20 days after insertion. This demonstrates the need to rule out infection in high-risk women before
inserting the IUS, and in this group a Chlamydia screen is advised.
Cost
The IUS costs around $250, so as a contraceptive the initial outlay is quite a lot.
Conclusion
The IUS is an effective contraceptive and treatment for heavy periods. It reduces menstrual pain, may be used with small to
moderate fibroids and has the potential as a treatment for severe PMS. It is associated with a low risk of ectopic pregnancy
and infection. It may be more difficult to insert than standard IUCD's, in some women can lead to mild hormonal effects, and
commonly causes irregular bleeding in the initial months, though this usually settles by 3-6 months. It is a particularly good
treatment choice for women with heavy periods who wish to avoid major surgery.
and remains in the womb for a fixed amount of time, after which it must be changed. It is different, however, in that it is
much more effective than usual IUCD's and avoids many of the side effects that put women off this choice of contraception.
In this review the abbreviation IUCD refers to this whole group of contraceptives,
and the terms Mirena and IUS will be used interchangeably.
Most IUCD's make a woman's periods heavier, but the Mirena actually makes
periods lighter than usual. Because of this, it is frequently used as a treatment for
heavy periods, even in women who don't need contraception. As can be seen in
the picture, it is made of a light, plastic, T-shaped frame with the stem of the 'T' a
bit thicker than the rest. This stem contains a tiny storage system of a hormone
called Levonorgestrel. This hormone is also used in contraceptive pills such as
Eugynon, Logynon, Microgynon, Ovran 30, Ovranette and Trinordial. In the Mirena,
however, a much lower dose is released than when you take the Pill (about 1/7th
strength), and it goes directly to the lining of the womb, rather than through the
blood stream where it may lead to the common progesterone-type side effects (see below).
How effective is the contraception?
If 1000 women used the Mirena IUS for a year, only one would fall pregnant. This compares with about 10 for the normal
IUCD, 20 for the Pill and 10-15 for the injection (Depot Provera). This is comparable to the effectiveness of sterilisation.
Mirena acts as a contraceptive in two ways: it makes the mucus at the neck of the womb (the cervix) much thicker,
preventing sperm from getting through and it also makes the lining of the womb extremely thin, stopping implantation. In
some women it prevents egg release (ovulation).
As with all IUCD's, if it does fail, there is a higher risk of ectopic pregnancy (a pregnancy located outside the womb, usually
in the tube). If you felt pregnant or had a positive pregnancy test, it is important to see your doctor to rule this out. Overall,
however, compared to women not using any contraception, the risk of ectopic pregnancy is greatly reduced (around 2 per
10,000 women each year [1]) because the IUS is such a good contraceptive.
If a pregnancy does occur with an IUCD, it is advisable to remove the contraceptive if possible - this reduces the risk of
bleeding, infection and miscarriage. Because failure is so rare, there is little information available on the effects on an
ongoing pregnancy with the Mirena still in place.
Fitting the Mirena IUS
Before it is inserted, the doctor will do an examination to make sure the womb is a normal size and there is nothing else
unusual to find. If there is some discharge, swabs will be taken to rule out infection before it is placed. The IUS is inserted
within a week of beginning a period - this helps to reduce the chance of expulsion and irregular bleeding (as the womb lining
is already quite thin at this time). It may be inserted immediately after surgical termination of pregnancy, but should be
deferred until 6 weeks after delivery of a baby.
A speculum is placed in the vagina, like when you have a normal smear test, and the Mirena is placed into the womb
through the cervix. Because it contains the storage of hormone, the stem is slightly wider than in normal IUCD's. This can
occasionally lead to difficulties with fitting, especially if you have not had a baby before. In this situation, it would be helpful
to use some local anaesthetic. It should be fitted by someone who has been trained and has experience in fitting IUCD's.
It is a good idea to take some painkillers a couple of hours before the fitting - this will help reduce any discomfort. A good
choice is Ibuprofen 400 mg, which can be bought over-the-counter at a chemist (please check that this is safe for you).
Most women do not find the insertion procedure very uncomfortable - usually much less than expected.
Once the IUS is in place, you won't be able to 'feel' it in your womb. Your doctor will show you how to check for the strings,
and it is very unusual for your partner to be aware of it during intercourse. After fitting, a further appointment should be made
for six weeks later to check the strings can still be seen. Yearly checks are advised after this appointment.
Removing or changing the Mirena
Removal involves a speculum examination again and the IUS is removed by pulling on the strings. This is only
uncomfortable for a second or two as it comes out. The hormone effect on the lining of the womb is reversed within a month
and normal periods and fertility returns.
The IUS will last 5 years and, if required, a new one can be inserted at the same time the old one is removed.
Mirena for heavy periods
Although the IUS was originally developed as a contraceptive, the discovery that it leads to much lighter periods was a great
bonus. Many gynaecologists now suggest the Mirena as a treatment for heavy periods if tablet treatment doesn't work.
After 3 months use, the average blood loss is 85% less, and by 12 months the flow is reduced by 97% every cycle [2].
About one third of women using the IUS will not have any periods at all. Although women initially find it a bit unusual not
having periods, it doesn't cause any problems. There is no 'build up' of blood, because the hormone in the IUS prevents the
lining of the womb from building up at all. Often it is the excessive thickening of this lining that is the cause of the problems
in the first place.
One study looked at 54 women who had heavy periods and were awaiting hysterectomy [3]. They all used the Mirena, and
just under 70% were taken off the waiting list because they were happy with the treatment. In another study of 50 similar
women, 82% avoided major surgery [4].
The Mirena is now licensed for treating heavy periods, and although this official licensing is relatively new, it has been used
'off-license' for some time in this way.
Painful periods
Although the IUS isn't primarily used for painful periods, two studies [4,5] have found that it does help in many cases (as
often as 80% of the time). If painful periods persist, it is usual to rule out any other problems with a laparoscopy.
Fibroids
Large fibroids are a common cause of heavy periods. If they are so large, or in such a position that they make the inside of
the womb an abnormal shape, it is unlikely that the Mirena will remain in place, and would not be helpful as a treatment.
With small to moderate size fibroids, it is quite reasonable to use the IUS and one study [5] has found that fibroids are less
common in women who use the Mirena. A further paper has found that in the 5 women studied, a Mirena actually reduced
the size of their fibroids [6]. This is only one report, of course, and the IUS cannot be recommended as a treatment for
fibroids based on this alone, though it is very interesting.
Premenstrual syndrome (PMS)
PMS is a syndrome that is thought to be caused by the varying hormones of the menstrual cycle. There have been
suggestions that the IUS may be useful as it will allow a continuous dose of hormones to be given (oestrogen) without the
worry of excessive stimulation of the lining of the womb. Usually oestrogens are combined with a course of a progestagen to
prevent this, but many women experience PMS-like symptoms with progestagens. At present there is little published in the
medical literature about the use of the Mirena in this way, but for severe cases, where hysterectomy is being considered as
the only remaining alternative, it would certainly be reasonable to consider this.
Hormone replacement therapy (HRT)
There is a growing experience with the use of the IUS for women who require hormone replacement therapy, but who have
either bad PMS-like symptoms or erratic bleeding on normal HRT preparations. The IUS with continuous implants, tablets or
patches of oestrogen provides good symptom relief with minimal side effects. As its use in this way is not generally
established in the UK, this would normally be prescribed under the care of a gynaecologist. In other countries (eg. Finland)
the IUS is licensed for use in this way and can be routinely used for up to 5 years.
Ectopic pregnancy
Women who have experienced an ectopic pregnancy are at a greater risk of this happening again in future pregnancies. For
this reason, they are advised to choose a type of contraception that does not increase this risk any further - in particular
they are encouraged to avoid IUCD's, as these are known to increase this risk. The risk of ectopic pregnancy is very much
lower with the IUS than in women not using any contraception (60 times lower, in fact). Although perhaps not a first choice,
the IUS may be considered when other contraceptives are really not suitable. As with most decisions in medicine, it is
about the balance of risk.
Side effects
Expulsion. In the early months of use, there is a very small chance that the IUS may dislodge and come out, either in part
or altogether. This risk may be greater than with other IUCD's, presumably because it is that bit larger. There may be
symptoms such as bleeding or persistent pain not relieved by simple pain killers, or it might be passed without any
discomfort at all. As the system reduces blood flow, sudden return of heavy periods might suggest this has happened.
Hormonal problems. Although the IUS delivers its hormone directly to the lining of the womb, it does lead to a slight
increase in progesterone levels in the blood stream. The levels are much lower than that found with the progestagen-only pill
(POP) and usually don't lead to side effects. If they do occur, most often they are mild and only last up to 4-6 weeks. Side
effects have included headache, water retention, breast tenderness or acne.
Ovarian cysts. Progestagen hormones increase the chance of benign, simple ovarian cysts. This is more common with the
higher hormone levels associated with the progestagen-only pill. Overall the risk is about 3 times higher (1.2% in IUS users
versus 0.4% normally). These cysts most often do not require any treatment and resolve on their own over 2-3 months. It is
usual to arrange follow-up ultrasound scans over this time if they do occur. The most common symptoms of a cyst is
abdominal pain that doesn't settle with simple painkillers.
Bleeding problems. These are without a doubt the most common problem associated with the Mirena. It takes about 3
months for the lining of the womb to thin down and during this time bleeding can be erratic or even heavy at times, but
almost always settles after 3-6 months. During the first month, 20% of users experience prolonged bleeding of more than 8
days duration, but by the third month only 3% have prolonged bleeding.
Pelvic infection. In general IUCD's increase the risk of infection of the womb, tubes and other pelvic organs. Studies looking
at Mirena suggest that this may not be the case, with the IUS being protective against infection, particularly in the age
group most at risk (<25y). Although this would fit with the thickening of the cervical mucus preventing infection getting
through the cervix, this finding is not universal in all studies. The actual long-term risk of infection is very low, at less than
1% with 5 years' use. A World Health Organisation study of over 22,000 users found that the infection risk was only
increased in the first 20 days after insertion. This demonstrates the need to rule out infection in high-risk women before
inserting the IUS, and in this group a Chlamydia screen is advised.
Cost
The IUS costs around $250, so as a contraceptive the initial outlay is quite a lot.
Conclusion
The IUS is an effective contraceptive and treatment for heavy periods. It reduces menstrual pain, may be used with small to
moderate fibroids and has the potential as a treatment for severe PMS. It is associated with a low risk of ectopic pregnancy
and infection. It may be more difficult to insert than standard IUCD's, in some women can lead to mild hormonal effects, and
commonly causes irregular bleeding in the initial months, though this usually settles by 3-6 months. It is a particularly good
treatment choice for women with heavy periods who wish to avoid major surgery.
