Nicorette said:
This is quite a complicated question but here goes: Sodium (NA+) is the major positive ion found in extracellular fluids (fluids outside cells); important for the water balance, conduction of nerve impulses, and muscle contraction. It is widely distributed, with 50% found in extracellular fluid, 40% in bone salts and 10% within cells. Absorption is rapid and almost complete, with excretion in urine, controlled by aldosterone.
It is the principle electrolyte maintaining osmotic pressure of extracellular fluids and water balance; as part of a bicarbonate buffer system. In this respect, it aids in the acid base balance of blood needed for normal neuromuscular function. It is also part of the pump for transport of glucose and other nutrients. The RDA of sodium is not established, but a sensible estimate would be around 2500mg.
Problems associated with excess sodium include hypertention and edema. Deficits, although rare, can possibly lead to excessive vomiting, diarrhea, sweating, nausea, abdominal and muscle cramping, plus convulsions.
FLUID AND ELECTROLYTE BALANCE:
Dehydration may occur as a result of excessive NaCl intake. However when sodium intake is too low, solute loss, water retention, or both can occur. When this is combined with a deficiency of aldesterone (Addison's disease), there is excessive ADH release.
REGULATION OF SODIUM BALANCE
Despite the crucial impotance of sodium, sodium receptors that specifically monitor Na+ levels in body fluids have not been found. Regulation of the sodium-water balance is inseperably linked to blood pressure and blood volume, and involves a variety of neural and hormonal controls. Na+ reabsorption does dictates that nearly all Na+ in the urinary filtrate will be absorbed. A complicated balance and interaction between aldesterone, sodium and potassium exists(the sodium potassium pump being extremely important). However I wont go into this, as I have probably bored you totears by now! Likewise, there is much to be said on the reabsorption of water and nutrients (including glucose amino acids, lactate, vitamins and most cations) in respect to passive and secondary active transport via the sodium-potassium pump and sodium reabsorption via primary active transport - but I'l leave it there for now.