In summary, the literature indicates that
supraphysiologic doses of AAS with an intact steroid
nucleus are immunosuppressive, while those with
alterations to the steroid nucleus are immunostimulatory.
Testosterone has been shown to decrease NK activity
and the number of lymphocytes by inhibiting the
differentiation of stem cells into B lymphocytes, thereby
depressing antibody production and resulting in a
reduction in immune function. Testosterone propionate
similarly depressed the immune system. In contrast,
treatment with testolactone, oxandrolone and stanozolol
improved immune function. While these effects were
long lasting, continuing to influence the immune system
several weeks after the administration of a single dose,
the effects of various dosing regimes and of treatment
with combinations of AAS have not been clearly
elucidated.
Clinical and experimental evidence suggests that
gonadal steroids regulate immunological function
[
95,111]. Some studies suggest that AAS are
immunosuppressive [102,112-116], while others suggest
that AAS enhance immune function [117]. However, the
nature of their effects on the immune system depends
on the type of AAS used and the dose and timing of
administration. It has been shown that different AAS can
act in either immunosuppressive or immunostimulatory
manner [52,102,103,107].
Mendenhall
et al. [103] also used intact and castrated
rats to test the effects of endogenous gonadal hormones.
The rats were treated for 8 days with oxandrolone
(1.1 mg/kg/day,) testosterone (1.1 mg/kg/day),
or oxandrolone combined with physiologic amounts of
testosterone (15 ÎĽg/day). After 8 days of treatment with
oxandrolone, intact animals experienced a 41% increase
in T cell proliferation function. Conversely, rats treated
with testosterone experienced a 36% reduction in T cell
proliferation function. Rats treated with oxandrolone
and physiologic testosterone gave results that were
not significantly different to baseline. Therefore, any
net immunostimulation was abolished by testosterone.
In general, castration resulted in an increase in
immune responses. Supraphysiologic doses of AAS,
as found during abuse, may mimic medical castration
by suppressing serum levels of gonadotropins (follicle-
stimulating hormone and luteinizing hormone) and
testosterone [
109]. However, treatment with oxandrolone
returned the DCH response in castrated rats to baseline
while treatment with oxandrolone and physiologic
testosterone produced an even greater suppression
(45%). Therefore only a direct immunosuppressive
effect was observed. These results appear to be linked
to the integrity of the steroid nucleus as those with
an intact steroid nucleus consistently produced an
immunosuppressive effect, while those with structural
alterations produced immunostimulation.
The above 3 cut and pastes are what related to it. Looks like anavar might have a great boosting capacity. Although it doesn't directly say that deca will improve T count it does infer that being a steroid that has an altered steroid nucleus it will improve immune function. My big question is which steroids fall into that category? It seems like deca, winny, and var do but what about all the other popular ones that weren't mentioned in the article?
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