OVERDOSAGE
There have been no reports of acute overdosage with anabolics.
DOSAGE AND ADMINISTRATION
The recommended daily dose in children and adults is 1-5 mg/kg body weight per day. The usual effective dose is 1-2 mg/kg/day but higher doses may be required, and the dose should be individualized. Response is not often immediate, and a minimum trial of three to six months should be given. Following remission, some patients may be maintained without the drug; others may be maintained on an established lower daily dosage. A continued maintenance dose is usually necessary in patients with congenital aplastic anemia.
One would assume that safety studies were done for FDA approval. I find the dosages amazingly high--higher than what a lot of bodybuilders would ever take. Consider that if you weigh 220 lbs, that equals 100 KG. At the minimun recommended dose of 1 mg/kg/day that would be 100mg of Anadrol 50 per day or 2 tablets per day. 2mg/kg/day would be 200 mg per day. And at the high end of 5 mg/kg/day, that would mean 500mg/day. Doesn't this seem like an awfully high dose? Does anyone know of anyone that has done this much? The lower doses of 1-2mg/kg/day are approved for long term use of a minimum of three to six months or longer, possibly permanently, depending on the expression of undesirable side effects.
I also know a physician that was involved in the safety studies of Anadrol with AIDS patients. He had a patient die within one week of starting him on Anadrol 50 from blood filled cysts in the liver (peliosis hepatis) so consequently he is not so keen on the drug and feels it CAN be dangerous. However, the dosage, I believe was 150 mg/day and you have to remember that AIDS patients are typically on MANY liver toxic medications at the same time so this would only compound any toxicity from the Anadrol 50. Also the patient alledgely was in very poor condition but volunteered for the study and had severe HIV related cachexia (wasting of lean body mass). So the death could not be causally linked necessarily to the Anadrol 50 for the study purposes and was discounted. I heard of one other patient on the same study that also died from the same reason and was also discounted for the same reason. So it is hard to definitively say whether the Anadrol caused it or if it was the straw that broke the camel's back in light of all of what else was going on. But it does serve as a word of caution for people that do not have healthy livers or are on liver toxic medications or are in seriously ill condition.