"Cock, exactly how does progestin interfere with 5-AR? Does it bind to 5-AR or inhibit 5-AR transcription... or...?"
Progesterone has a higher affinity for 5-AR, it is acting through competitive inhibtion.
"The reason being, if indeed progestin does block the actions of 5-AR by binding to it directly, that would mean that if you blocked progestin from its appripriate receptors in various tissues (ex. breast tissue) then it would leave more progestin in circulation. This would leave more for 5-AR interaction. Blocking 5-AR will prevent the conversion of nandralone to DHN. Nandralone has VERY high androgenic activity within the scalp... So basicly what I'm saying is that if progestin binds to 5-AR, Deca+Winny could mean additional hairloss outside of winny's direct androgenic activity within the scalp..."
Progesterone inhibition of 5-AR would definately cause more hair loss if used with Nandrolone, since it would prevent Nandrolone from converting to the weaker androgen, DHN. This is the same reason not to use Nandrolone with Finasteride. But remember that this is probably only related to progesterone, and not mediated through the progesterone receptor. The structure of progesterone imparts a greater affinity for 5-AR, so this does not apply to all progestins.
Progesterone has a higher affinity for 5-AR, it is acting through competitive inhibtion.
"The reason being, if indeed progestin does block the actions of 5-AR by binding to it directly, that would mean that if you blocked progestin from its appripriate receptors in various tissues (ex. breast tissue) then it would leave more progestin in circulation. This would leave more for 5-AR interaction. Blocking 5-AR will prevent the conversion of nandralone to DHN. Nandralone has VERY high androgenic activity within the scalp... So basicly what I'm saying is that if progestin binds to 5-AR, Deca+Winny could mean additional hairloss outside of winny's direct androgenic activity within the scalp..."
Progesterone inhibition of 5-AR would definately cause more hair loss if used with Nandrolone, since it would prevent Nandrolone from converting to the weaker androgen, DHN. This is the same reason not to use Nandrolone with Finasteride. But remember that this is probably only related to progesterone, and not mediated through the progesterone receptor. The structure of progesterone imparts a greater affinity for 5-AR, so this does not apply to all progestins.