Mike, just don't dive into this without finding a doc that is well versed in HRT. This is life long, and much more involved than 1 shot a week in the long run. Yes, it can be very beneficial and has changed my life, but it is a major decision. I used Swale and then found a holistic doc in my area that is pretty good. Make sure to explore the natural route first if you can. If not, try the gel first. Swale posts over at Meso you may want to check it out. Learn the most you can first. Good luck....