In terms of bending the elbow, your body does it best when you are using a neutral grip. The brachiallis is the true prime mover involved in elbow flexion. When you have a palms-up grip, you are not able to use your brachiallis which makes the biceps do all of the work - I didn't metion foreams. As biceps are more heavily involved in bending the arm when fully supinated, therefore, curl grip exercises are best for training the biceps because the offer a degree of isolation, however, the flexors of the arm are STRONGEST when in neutral position.
You don't deadlift with a curl grip because it puts too much direct stress on the biceps. Same with rowing in a boat, starting a lawnmower or carrying shit.
At the end of the day, it's just sacks of meat and fluid connected to bones at certain points.