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napsgear
genezapharmateuticals
domestic-supply
puritysourcelabs
RESEARCHSARMSUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsRESEARCHSARMSUGFREAKeudomestic

Stretchmark cream, Ladies??

karde

New member
The wife has some marks on her bum and her boobs, and wants to try this stuff: http://www.strivectin.com/

"In a remarkable turn of events, arguably one of the strangest in the history of cosmetics, women across the country are putting a stretch-mark cream called StriVectin-SD® on their face to diminish the appearance of fine lines, wrinkles and crows’ feet. And, if consumer sales are any indication of a product’s effectiveness, StriVectin-SD is nothing short of a miracle. Women (as well as a growing number of “Boomer” men) are buying so much StriVectin-SD that finding a tube at your local cosmetic counter has become just about impossible. Has everyone gone mad? Well… not really. "


To me, it kinda sounds like BS. I wanted to know if anybody here has tried it.
 
karde said:
The wife has some marks on her bum and her boobs, and wants to try this stuff: http://www.strivectin.com/

"In a remarkable turn of events, arguably one of the strangest in the history of cosmetics, women across the country are putting a stretch-mark cream called StriVectin-SD® on their face to diminish the appearance of fine lines, wrinkles and crows’ feet. And, if consumer sales are any indication of a product’s effectiveness, StriVectin-SD is nothing short of a miracle. Women (as well as a growing number of “Boomer” men) are buying so much StriVectin-SD that finding a tube at your local cosmetic counter has become just about impossible. Has everyone gone mad? Well… not really. "


To me, it kinda sounds like BS. I wanted to know if anybody here has tried it.

I know Strivectin...it's sold as an over-the-counter substitute for botox, but I hear it's not even that great for wrinkles on the face. It is pricy stuff too. I've heard people recommend the Avon cellulite fix over it which is supposedly more effective and affordable. Others say cocoa butter and vitamin E oil also are helpful. I'd go those routes first before investing in a $130+ tube of Strivectin.
 
Ok, I did some looking, the active ingredient (or functional isolate as they like to call it) is:
"Palmitoyl Pentapeptide-3 (Ceramide Oligopeptide-3) is clinically proven to regenerate the skin's upper layers by stimulating collagen production and thickening the epidermis—not unlike the regeneration."

Here are the clinical studies they quote:
"Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin1
L. R. Robinson, N. C. Fitzgerald, D. G. Doughty, N. C. Dawes, C. A. Berge and D. L. Bissett
Synopsis

The palmitoyl pentapeptide palmitoyl-lysine-threonine-threonine-lysine-serine (pal-KTTKS) is a synthetic material that was designed as a topical agent to stimulate collagen production and thus provide a skin anti-wrinkle benefit. To determine if pal-KTTKS is effective, the clinical study reported here was conducted. Caucasian female subjects (n = 93, aged 3555) participated in a 12-week, double-blind, placebo-controlled, split-face, leftright randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS. Pal-KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis. In self-assessments, subjects also reported significant fine line/wrinkle improvements and noted directional effects for other facial improvement parameters."


And there is one I haven't been able to track down yet with the title:

1 PO438 "Relevance of antiwrinkle treatment of a peptide: 4 months clinical double blind study vs excipient." 20th World Congress of Dermatology (60 subjects - 4 mos.)

There are several companies who make similar stuff, http://1800patches.com/oht/index.html is another.
 
Also, I found this on a Dr.'s website, but he does botox, so he of course will be biased as well:

"StriVectin-SD ($135 for 6 ounces) is the product that started the whole "better than Botox" craze. It went from email spam and ads in Parade magazine to prominent shelf space in Nordstrom and Sephora. Interestingly enough, StriVectin didn't start as an anti-wrinkle product. Rather, its original claim to fame was for eliminating stretch marks. However, the only studies proving StriVectin's benefits for stretch marks were paid for by Klein-Becker, the company that distributes StriVectin. That's about as reliable as a Marlboro coming out with a study that says cigarettes are safe.

Though there is no way to be sure, it seems Klein-Becker simply decided that the market for a stretch mark product wasn't as lucrative as one for an anti-wrinkle product. So the company modified their ads, stating they were surprised to find that not only was StriVectin-SD getting rid of women's stretch marks, but it also got rid of their facial wrinkles, and we now have the astounding "anti-wrinkle breakthrough of the decade." Regrettably, they do not have to back up this claim with supportive research to sell this kind of hyperbole. All any company has to do is claim their product will get rid of wrinkles and women will buy it in droves, as evidenced by the fact that StriVectin-SD has been the best-selling product in department stores since November 2003, with sales topping $30 million between January and June 2004 (Source: The Rose Sheet, June 7, 2004, page 3)! The con is on, and many consumers are buying it (literally and figuratively).

Perhaps the most enticing part of StriVectin's ads are the portions that read, "The active formula in StriVectin-SD has recently been shown in clinical trials to significantly reduce that category of fine lines and facial wrinkles that can add 10-15 years to your appearanceÝand even reduce the dark circles under your eyes ...without irritation, painful injections, or surgery." Another statement reads "in fact, [StriVectin-SD] is the only topical formulation clinically proven to effectively confront every aspect of wrinkle reduction." It is easy to debunk all of this overblown nonsense by pointing out the product's lack of sunscreen; perhaps StriVectin overlooked the voluminous research about sun exposure's deleterious, wrinkling, and discoloring effects on skin. That omission alone puts their claims in the category of overstatement and nothing more.

The two studies quoted in StriVectin's ads were presented at the 20th World Congress of Dermatology, held in July 2002. These papers examined the effects of the ingredient palmitoyl pentapeptide-3 (one of the ingredients in Strivectin, though they advertise this ingredient with the name Pal-KTTKS) and compared it to vitamin C and retinol. Of course, according to them, palmitoyl pentapeptide-3 won. However, there is no published research substantiating the results, the studies were from the ingredient manufacturer, and StriVectin declined to send us any documentation. Further, presenting a paper at a dermatology meeting is not the same as having your information published in a medical journal with strict protocol standards.

With lack of substantiated research but a strong desire to capture baby boomers' dollars, Klein-Becker has taken these claims and almost single-handedly created a market for "works like Botox" products. StriVectin-SD is supposedly preferable because of its long-term results versus the short-term results (and repeated treatments) of Botox. A Dr. Nathalie Chevreau is quoted in the ad, saying "the cumulative effects of using a product like StriVectin become more noticeable every day, and ultimately lasts longer than Botox." Chevreau is hardly an impartial source-she works for Klein-Becker! Further, Dr. Chevreau is a licensed dietician in Utah, a fact that is conveniently left out of StriVectin's ad because it would conflict with her credibility as a medical doctor speaking about the legitimate benefits of an antiwrinkle cream.

If you are still wondering if there is any way possible that StriVectin-SD might somehow be better than Botox, the short answer is no-and that means no way, and no how. It certainly isn't better than the daily use of an effective sunscreen! StriVectin is merely a moisturizer with some very good emollients, water-binding agents, antioxidants, and peptides. Unfortunately, this product also contains peppermint oil, a problematic skin irritant. I suspect this was included to make the skin tingle (a sensitizing reaction) to create the impression that the product is "doing something" to the skin. StriVectin-SD won't alter the wrinkling on any part of your face, in the long term or in the short term.

Riding on the success of StriVectin-SD, several cosmetic companies have created their own products claiming to be better than Botox or better than cosmetic corrective surgery."
 
Roonytunes said:
I know Strivectin...it's sold as an over-the-counter substitute for botox, but I hear it's not even that great for wrinkles on the face. It is pricy stuff too. I've heard people recommend the Avon cellulite fix over it which is supposedly more effective and affordable. Others say cocoa butter and vitamin E oil also are helpful. I'd go those routes first before investing in a $130+ tube of Strivectin.

I found this writting on Avon, I am not sure if it is the product you are talking about. It doesn't mentional cellulite, but it's marketed as anti-wrinkle etc.

"Avon

Anew Clinical Deep Crease Concentrate with Bo-Hylurox ($32 for 1 ounce) has a name not only reminiscent of Botox, but is advertised to make you wonder why anyone would subject themselves to an injection when they can achieve the same (or at least similar) results with this water-based serum. Sold with the scare-tactic tag line "Look stunning, not stunned," Avon's alternative to Botox claims to "reduce the overall length, depth and number of deep expression lines around your eyes, mouth and forehead, the areas that are in motion whenever you show emotion." Well, when done correctly, Botox injections absolutely do not make a person look stunned-the list of Hollywood celebrities who have had Botox injections is what's really stunning, and they don't look "stunned!" As one Hollywood plastic surgeon told me, if Botox was a problem half the town would be sick. Unlike genuine Botox injections, this Avon product absolutely cannot get rid of wrinkles.

Anew Clinical Deep Crease Concentrate contains two ingredients that are supposedly responsible for the crease-filling and wrinkle-smoothing. The first is Portulaca oleracea, a plant extract. Avon maintains it "helps you lose those hard-to-treat creases while keeping your facial expressions, naturally." However, there is no substantiated or published research showing Portulaca oleracea has that (or any) anti-wrinkle effect. Research has shown that it may have anti-inflammatory or analgesic properties, and it is also believed to be effective topically for wound healing (Sources: Journal of Ethopharmacology, October 2003, pages 131-136, and December 2000, pages 445-451). But none of that is related to treating expression lines in any way, shape, or form or duplicating Botox's effect on wrinkles. One study did examine Portulaca's effect on brain activity and resulting muscle relaxation, but the substance was used in a 10% concentration and injected into pigs' stomachs, quite different from applying lesser amounts of this ingredient to skin (Source: Journal of Ethnopharmacology, July 2001, pages 171-176).

The second hyped ingredient is acetyl hexapeptide-3 (trade name: argireline), which is described in detail in the DDF Wrinkle Relax review below.

DDF

Wrinkle Relax (previously known as Faux-Tox) ($75 for 0.5 ounce) is another Botox wannabe. This pricey product, which over a year's time wouldn't cost that much less than an actual Botox treatment, claims to contain a non-toxic, anti-aging peptide, chemically combined from naturally derived amino acids, [that] helps prevent fine lines induced by repeated facial movements without the loss of facial expression." And the results are supposed to be visible within two weeks. The miracle ingredient in this lightweight lotion is Argireline, which is the trade name for the synthetically derived peptide called acetyl hexapeptide-3. The company selling acetyl hexapeptide-3 is Centerchem (www.centerchem.com), an ingredient manufacuter based in Spain and, according to their Web site, "Argireline works through a unique mechanism which relaxes facial tension leading to a reduction in superficial facial lines and wrinkles with regular use. Argireline has been shown to moderate excessive catecholamines release." Other than Centerchem's assertions, there isn't a shred of research substantiating any part of it.

However, even if it were vaguely true, these effects would not be good news for your body because you wouldn't want any cosmetic without any safety data, efficacy documentation, or independent research messing around with your catecholamines. Catecholamines are compounds in the body that serve as neurotransmitters such as epinephrine, adrenaline, and dopamine. Epinephrine is a substance that prepares the body to handle emergencies such as cold, fatigue, and shock. A deficiency of dopamine in the brain is responsible for the symptoms of the Parkinson's. None of that sounds like something you want a cosmetic to inhibit or reduce. What if you accidentally overuse the product or apply too much? What is excessive for your body? The entire notion is more worrisome than almost anything I've encountered in my research thus far. However, the good news is that the physicians I've interviewed say this ingredient can't perform as DDF suggests.

Also available is DDF's Anti-Wrinkle Eye Renewal Treatment ($48 for kit). The kit includes four products, with the main attraction being the Anti-Wrinkle Dermal Gel, a water-based serum that contains the same "active" ingredient the company uses in their Wrinkle Relax product above, with equally suspect claims. In addition, there are clinical studies for Argireline revealing that this ingredient was not as effective as Botox (Source: www.cremedevie.com/clinical_details.htm). Again, this is not an ingredient to consider because there are too many unknowns about its effect on biological processes, not to mention its dubious anti-wrinkle claims."
 
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