Genome:
Que a su vez incrementa el volumen sanguineo, razon por la que se te incrementa la vascularidad .... Por cierto que la niacina tiene algunas propiedades interesantes adicionales, pues esta comprobado que incrementa el HDL (1, 2, 3 ... hay demasiadas referencias, solo pongo las mas recientes), baja los lipidos en la sangre (1, 2) y sube la GH de un 300 a un 600 % (4).
----------------------------------------------------------
(1)
Am J Cardiol 2000 Dec 21;86(12A):5L-10L Related Articles, Books, LinkOut
The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides: a current review.
Kwiterovich PO Jr.
Johns Hopkins Lipid Research Atherosclerosis Division, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
Three major interconnected pathways are involved in lipoprotein metabolism: (1) the transport of dietary or exogenous fat; (2) the transport of hepatic or endogenous fat; and (3) reverse cholesterol transport. These pathways are interdependent and disruptions in one will affect the function and products of the others. For example, a mutation such as one in the ABC1 protein can disrupt normal transport and processing of cholesterol. High-density lipoprotein cholesterol (HDL-C) appears to have cardioprotective properties because of its involvement in certain processes such as reverse cholesterol transport and inhibition of low-density lipoprotein cholesterol (LDL-C) oxidation. Certain agents, such as niacin, which increases HDL-C, lowers lipoprotein (a), and targets specific enzymes or receptors, may be highly beneficial for patients at risk of cardiovascular disease.
Publication Types:
Review
Review, tutorial
PMID: 11374859 [PubMed - indexed for MEDLINE]
------------------------------------------------
(2)
Am J Cardiol 2000 Dec 21;86(12A):46L-50L Related Articles, Books, LinkOut
Raising high-density lipoprotein cholesterol with niacin and fibrates: a comparative review.
Sprecher DL.
Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA.
A growing number of trials that used fibrates and niacin alone or in combination with other lipid-altering agents have shown that both these drugs are effective for reducing total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides, and for increasing high-density lipoprotein cholesterol (HDL-C) levels. These lipid changes are associated with a reduction in events such as fatal and nonfatal myocardial infarction, stroke, and transient ischemic attack. In angiographic trials, they are associated with disease regression, increased minimal luminal diameter, and protection from risk of new lesions. In a head-to-head comparison study, niacin 2,000 mg/day increased HDL-C more than gemfibrozil 1,200 mg/day, and decreased the total cholesterol-to-HDL-C ratio, lipoprotein (a) (Lp[a]), and fibrinogen levels significantly more. Combination therapies of niacin plus a resin or statin are effective, well tolerated, and safe.
Publication Types:
Review
Review, tutorial
PMID: 11374856 [PubMed - indexed for MEDLINE]
-----------------------------------------------
(3)
Am J Cardiol 2000 Dec 21;86(12A):35L-40L Related Articles, Books, LinkOut
The pharmacokinetics and pharmacodynamics of agents proven to raise high-density lipoprotein cholesterol.
Piepho RW.
School of Pharmacy, University of Missouri-Kansas City, 64110-2499, USA.
Bile acid sequestrants, fibric acid derivatives (fibrates), hydroxy-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors ("statins"), and niacin are able to increase HDL-C serum concentrations to varying degrees. Bile acid sequestrants are the least effective, whereas niacin is the most powerful agent for increasing HDL-C levels. Because of 2 alternate metabolic pathways of niacin breakdown, flushing or hepatotoxicity can occur in patients taking niacin. These effects can be mediated in a carefully designed formulation of niacin that releases the drug at a predictable rate. Niacin has few drug interactions and is a relatively inexpensive means of increasing HDL-C. A combination formulation that combines niacin plus a statin has shown promise in ongoing clinical trials.
PMID: 11374854 [PubMed - indexed for MEDLINE]
------------------------------------------------
(4)
Med Sci Sports Exerc 1995 Jul;27(7):1057-62 Related Articles, Books, LinkOut
Physiological and performance responses to nicotinic-acid ingestion during exercise.
Murray R, Bartoli WP, Eddy DE, Horn MK.
Exercise Physiology Laboratory, Gatorade Sports Science Institute, Barrington, IL 60010, USA.
The purpose of this study was to assess how selected physiological and performance responses are affected when the normal increase in plasma free fatty acid concentration during exercise is blunted by ingesting nicotinic acid. On four occasions, 10 subjects cycled at 68 +/- 1% VO2peak for 120 min followed by a timed 3.5-mile performance task. Every 15 min during exercise, subjects ingested 3.5 ml.kg LBM-1 of one of four beverages: 1) water placebo (WP), 2) WP + 280 mg nicotinic acid.l-1 (WP + NA), 3) 6% carbohydrate-electrolyte beverage (CE), and 4) CE + NA. Ingestion of nicotinic acid (WP + NA and CE + NA) blunted the rise in FFA associated with WP and CE; in fact, NA ingestion effectively prevented FFA from rising above rest values. The low FFA levels with NA feeding were associated with a 3- to 6-fold increase in concentrations of human growth hormone throughout exercise. The mean performance time for CE (10.7 min) was significantly less than for WP (12.2 min) and WP + NA (12.8 min), but did not differ from CE + NA (11.4 min). The results indicate that blunting the normal rise in FFA alters the hormonal response to exercise and reduces the capacity to perform high-intensity exercise.
Publication Types:
Clinical trial
Controlled clinical trial
PMID: 7564973 [PubMed - indexed for MEDLINE]
------------------------------------------------
Saludos.
Please Scroll Down to See Forums Below 
