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questions for yohimbine hcl users?
- Thread starter rx123
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macrophage69alpha
New member
rx123,
20mg is the "starting dose"
The point at which "unpleasant" side effects occur will vary CONSIDERABLY- some people can tolerate, actually enjoy 100mg+ per application
btw- with appropriate dose for you there are pleasant stimulatory and slight mood elevating side effects as well-
dosing can be 2 or more times a day- with more frequent dosing use lower doses and be careful of systemic buildup (as the yohimbine applied earlier is slowly released)- while the only side effect is that you will feel unpleasant(headache, lethargic, chills)--- it is still something to be avoided.
on a pleasant note- these side effects subside in 45min-1.5hrs and once you find your tolerance point it is easy to avoid.
peace
20mg is the "starting dose"
The point at which "unpleasant" side effects occur will vary CONSIDERABLY- some people can tolerate, actually enjoy 100mg+ per application
btw- with appropriate dose for you there are pleasant stimulatory and slight mood elevating side effects as well-
dosing can be 2 or more times a day- with more frequent dosing use lower doses and be careful of systemic buildup (as the yohimbine applied earlier is slowly released)- while the only side effect is that you will feel unpleasant(headache, lethargic, chills)--- it is still something to be avoided.
on a pleasant note- these side effects subside in 45min-1.5hrs and once you find your tolerance point it is easy to avoid.
peace
takniteasy
Banned
I have used the topical yohimbine hcl and knew when I had too much when I had the symptoms that Macro described. Fatigue, headache and chills. I also had a problem with water retention. Not everyone has this problem, I just retain water more than most. I alleviated these side affects by lowering my dosage of topical (20mg 2x per day) and cycling my use (3-4 days on 1-2 days off). Now my body is responding very well and I recommend the topical use as well as oral ( such as an NYC). Macro has a great post, very informative about yohimbine hcl. You could try a search on topical yohimbine hcl application to find it.
Renee
Renee
takniteasy
Banned
I almost forgot, I started seeing results in about 2-3 weeks. I believe if your BF is lower, you may see results sooner. I have been using this for 4-5 weeks now and plan to stop completely at Thanksgiving.
Renee
Renee
macrophage69alpha
New member
ulter said:AF Store is where to find it.
I had decided to leave this issue alone, but since Ulter feels compelled to spam, I feel compelled to mention that with typical transdermal delivery, drugs that penetrate the skin barrier and traverse the epidermis and dermis are rapidly taken up by the dermal microvasculature, where they are delivered systemically (just like with orals) -- this is very well characterized in the literature (1,2,3) -- with direct tissue penetration being limited to 1-4 mm, which obviously is not exactly deep into the adipose tissue.
Let me repeat, if nothing is done to bypass the dermal microvasculature, our drug enters systemic circulation before it ever reaches the adipose tissue.
And, considering that Yohimbine HCl has good oral bioavailability, if the dermal microvasculature is not taken into account, we end up with a product that not only does not localize delivery, it does not even deliver it systemically as efficiently as an oral would do.
Considering these products cost far more than there oral counterparts, and could also be thought of as inconvenient in that you have to rub them on your body, wait for them to dry, etc., any supplement developer who does not take dermal uptake into account has obviously missed the boat quite badly.
And, guess what... there is only one substance I have seen in the literature that facilitates this.
And, guess what else... Yohimburn's formulation does not employ it.
ParDeus
www.avantlabs.com
References:
1. Roberts MS. Targeted drug delivery to the skin and deeper tissues: role of physiology, solute structure and disease.Clin Exp Pharmacol Physiol 1997 Nov;24(11):874-9
2. Singh P, Roberts MS. Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application. J Pharmacol Exp Ther 1994 Jan;268(1):144-51
3. Singh P, Roberts MS Dermal and underlying tissue pharmacokinetics of lidocaine after topical application..J Pharm Sci 1994 Jun;83(6):774-82
takniteasy
Banned
PD, I have a ? for you. I visited your website out of curiosity and read the info on your product. You stated that you used it with an EC (does this not stand for ephedrine, caffeine?), however in the info/ingredients, there is an explicit warning against using stimulants with your product. Why? I see a contradiction there and kinda figured you could clear it up.
takniteasy said:
Labeling instructions have to lean toward the safe/conservative side for liability purposes.
When experimenting on myself, I do not.
ParDeus
www.avantlabs.com
"Labeling instructions have to lean toward the safe/conservative side for liability purposes.
When experimenting on myself, I do not."
Hehe same here. I would not explicitly RECOMMEND anyone mix yohimbine with other drugs. But I certainly have mixed it with norephedrine and caffeine and had no health problems unless you consider extreme leaness to be a health problem! However, everyone is different and if you do use or mix yohimbine, please go slowly and start with low doses.
So Par Deus, how's the research on the comparative effectiveness of your super transdermal formulation compared to standard topical or oral delivery methods. If ya ever need a volunteer to help with a blind trial of delivery vehicle plus and minus yohimbine on female thighs just drop me a line!
When experimenting on myself, I do not."
Hehe same here. I would not explicitly RECOMMEND anyone mix yohimbine with other drugs. But I certainly have mixed it with norephedrine and caffeine and had no health problems unless you consider extreme leaness to be a health problem! However, everyone is different and if you do use or mix yohimbine, please go slowly and start with low doses.
So Par Deus, how's the research on the comparative effectiveness of your super transdermal formulation compared to standard topical or oral delivery methods. If ya ever need a volunteer to help with a blind trial of delivery vehicle plus and minus yohimbine on female thighs just drop me a line!
Guess what you haven't looked hard enough. It now seems you looked for a substance to deliver Yohimbine and stopped looking after you found one. If you would have looked further you would have found that there are more. Yohimburn uses one of them. Which would explain why there are over 200 people on this board using Yohimburn and not one has said it didn't burn off fat for them. In fact, not one has made any complaint whatsoever. They all love it.
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ulter said:
Feel free to supply a reference where it was shown to localize distribution to deep tissues, not just the skin (which, of course is superficial to the adipose tissue -- with the all important dermal microvasculature standing between them).
ParDeus
www.avantlabs.com
MR. BMJ said:
The data on polysacharides (a component of aloe) shows localization to the skin, not deeper tissues, so do not get your hopes up for that reference.
ParDeus
www.avantlabs.com
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