questions for yohimbine hcl users?

[rx123]

20mg is the starting dose applied topically, is this correct? how long before effects are seen.....how often should it be applied....what sides occur.........how high should one go?

thanks

 

[Aileen]

you can find some helpful answers in the mens anabolic discussion board regarding Yohimbine for women and men, just scroll all the way down till you see the topic. I believe there are two threads.

 

[macrophage69alpha]

rx123,

20mg is the "starting dose"

The point at which "unpleasant" side effects occur will vary CONSIDERABLY- some people can tolerate, actually enjoy 100mg+ per application

btw- with appropriate dose for you there are pleasant stimulatory and slight mood elevating side effects as well-

dosing can be 2 or more times a day- with more frequent dosing use lower doses and be careful of systemic buildup (as the yohimbine applied earlier is slowly released)- while the only side effect is that you will feel unpleasant(headache, lethargic, chills)--- it is still something to be avoided.

on a pleasant note- these side effects subside in 45min-1.5hrs and once you find your tolerance point it is easy to avoid.

peace

 

[takniteasy]

I have used the topical yohimbine hcl and knew when I had too much when I had the symptoms that Macro described. Fatigue, headache and chills. I also had a problem with water retention. Not everyone has this problem, I just retain water more than most. I alleviated these side affects by lowering my dosage of topical (20mg 2x per day) and cycling my use (3-4 days on 1-2 days off). Now my body is responding very well and I recommend the topical use as well as oral ( such as an NYC). Macro has a great post, very informative about yohimbine hcl. You could try a search on topical yohimbine hcl application to find it.

Renee

 

[takniteasy]

I almost forgot, I started seeing results in about 2-3 weeks. I believe if your BF is lower, you may see results sooner. I have been using this for 4-5 weeks now and plan to stop completely at Thanksgiving.

Renee

 

[macrophage69alpha]

 

[OTCbooty]

I have GOT to try this stuff some day...

 

[Ulter]

AF Store is where to find it.

 

[Par Deus]

AF Store is where to find it.

I had decided to leave this issue alone, but since Ulter feels compelled to spam, I feel compelled to mention that with typical transdermal delivery, drugs that penetrate the skin barrier and traverse the epidermis and dermis are rapidly taken up by the dermal microvasculature, where they are delivered systemically (just like with orals) -- this is very well characterized in the literature (1,2,3) -- with direct tissue penetration being limited to 1-4 mm, which obviously is not exactly deep into the adipose tissue.

Let me repeat, if nothing is done to bypass the dermal microvasculature, our drug enters systemic circulation before it ever reaches the adipose tissue.

And, considering that Yohimbine HCl has good oral bioavailability, if the dermal microvasculature is not taken into account, we end up with a product that not only does not localize delivery, it does not even deliver it systemically as efficiently as an oral would do.

Considering these products cost far more than there oral counterparts, and could also be thought of as inconvenient in that you have to rub them on your body, wait for them to dry, etc., any supplement developer who does not take dermal uptake into account has obviously missed the boat quite badly.

And, guess what... there is only one substance I have seen in the literature that facilitates this.

And, guess what else... Yohimburn's formulation does not employ it.

ParDeus
www.avantlabs.com


References:

1. Roberts MS. Targeted drug delivery to the skin and deeper tissues: role of physiology, solute structure and disease.Clin Exp Pharmacol Physiol 1997 Nov;24(11):874-9

2. Singh P, Roberts MS. Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application. J Pharmacol Exp Ther 1994 Jan;268(1):144-51

3. Singh P, Roberts MS Dermal and underlying tissue pharmacokinetics of lidocaine after topical application..J Pharm Sci 1994 Jun;83(6):774-82

 

[takniteasy]

PD, I have a ? for you. I visited your website out of curiosity and read the info on your product. You stated that you used it with an EC (does this not stand for ephedrine, caffeine?), however in the info/ingredients, there is an explicit warning against using stimulants with your product. Why? I see a contradiction there and kinda figured you could clear it up.