Ifonly
Member
Ok estrogens and progestogens are important to mammary gland growth, however they do not create gyno in the absence of anterior pituitary hormones . So to be honest neither estrogen alone nor estrogen plus progesterone can sustain breast development without other factors being involved, like GH or IGF-1, as seen in studies when they have administration estrogen and GH to hypophysectomized and oophorectomized female rats, which in the end showed breast ductal development. The GH effects on ductal growth are made through stimulation of IGF-1. This is demonstrated by studies of estrogen and GH administration to IGF-1 knockout rats that showed significantly decreased mammary development when compared to age-matched IGF-1- intact controls. Combined estrogen and IGF-1 treatment in these IGF-1 knockout rats restored mammary growth. In addition, Walden et al. demonstrated that GH-stimulated production of IGF-1 mRNA in the mammary gland itself, suggesting that IGF-1 production in the stromal compartment of the mammary gland acts locally to grow breast. again other data indicates that estrogen promotes GH secretion and raises GH levels, stimulating the production of IGF-1, which works with with estrogen to induce ductal development.
Like estrogen, progesterone has minimal effects in breast development without concomitant anterior pituitary hormones; again indicating that progesterone interacts closely with pituitary hormones. Studies have also shown this to be factual.
Prolactin is another anterior pituitary hormone integral to breast development. Prolactin is not only secreted by the pituitary gland but may be produced in normal mammary tissue epithelial cells and breast tumors. Prolactin stimulates epithelial cell proliferation only in the presence of estrogen and enhances lobulo-alveolar differentiation only with concomitant progesterone.
Gynecomastia is extremely complicated and honestly I do not know every last thing there is to know about it. I know a lot and I am learning more every day. I can find the information and I can understand it. But the causes of it are vast and far reaching into many topics even outside of the use of steroids its still complicated.
In your case clomid 25mg every day and dostinex .5mg every other day should handle the problem my friend. Please remember to come back with your feed back and results. Because its always good for others to see things first hand. Even if they see my advice seeing it in action trumps all right.![]()
be sure you are not using the forma higher than 5 pumps am and pm as well.
Ok. Sounds a plan. Ill get on that.
Could I use toremifene or some other serm. Because the emotional sides I have had with clomid (25mg/day) were unreal!!!! Real fucking bad. Dnt won't to experience that again.

Many thanks bud!