i was very prone to depression when i was 14-18 (i'm 23 now), and then it just went away- but when i started clomid as an anti-e recently (i ran out of nolvadex and i had some around), i almost had a friggin' meltdown. the depression and anxiety came back over the course of two days (even worse than it had been when i was a teenager), and it continued for almost a month until i realized what was causing it. stopped the clomid, and two days later i was fine. different things affect different people different ways-clomid is something that is considered benign, but i would be VERY careful w/ it if you are prone to depression or anxiety