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Oxytocin on the Early Show saturday morning

while not able to comment specifically on the reasons for non response (as am not entirely familiar with oxytocin, currently engaged in other projects-- though its on the list :p ), can say that response to various drugs and hormones can vary SIGNIFICANTLY between users because of a host of individual genetic and biochemical variances.
 
The claims we make about are exactly what the findings of researchers have said.
I can't be expected to answer for others who use it and get the same feeling shown in the research. I am not them and don't see the world with their eyes. I CAN tell you how I feel on it. I will post the results of the study that was written up in The Wall Street Journal, The Washington Post, MSNBC and not the Today Show. I can't explain your reaction any more than I can explain why Krishna can't use test but can use deca. We're all different. Most people get a very good feeling from using Oxytocin. It's a hormone that affects everything from your orgasm to your comfort in a social situation.

1: J Neurosci. 2005 Dec 7;25(49):11489-93.

Oxytocin modulates neural circuitry for social cognition and fear in humans.
Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, Gruppe H, Mattay VS, Gallhofer B, Meyer-Lindenberg A.

Cognitive Neuroscience Group, Center for Psychiatry and Psychotherapy, Justus-Liebig University, D-35385 Giessen, Germany.

In non-human mammals, the neuropeptide oxytocin is a key mediator of complex emotional and social behaviors, including attachment, social recognition, and aggression. Oxytocin reduces anxiety and impacts on fear conditioning and extinction. Recently, oxytocin administration in humans was shown to increase trust, suggesting involvement of the amygdala, a central component of the neurocircuitry of fear and social cognition that has been linked to trust and highly expresses oxytocin receptors in many mammals. However, no human data on the effects of this peptide on brain function were available. Here, we show that human amygdala function is strongly modulated by oxytocin. We used functional magnetic resonance imaging to image amygdala activation by fear-inducing visual stimuli in 15 healthy males after double-blind crossover intranasal application of placebo or oxytocin. Compared with placebo, oxytocin potently reduced activation of the amygdala and reduced coupling of the amygdala to brainstem regions implicated in autonomic and behavioral manifestations of fear. Our results indicate a neural mechanism for the effects of oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.


Horm Behav. 2005 Dec;48(5):522-7. Epub 2005 Aug 18.

Oxytocin is associated with human trustworthiness.

Zak PJ, Kurzban R, Matzner WT.
Center for Neuroeconomics Studies, Claremont Graduate University, Claremont, CA 91711-6165, USA. [email protected]

Human beings exhibit substantial interpersonal trust-even with strangers. The neuroactive hormone oxytocin facilitates social recognition in animals, and we examine if oxytocin is related to trustworthiness between humans. This paper reports the results of an experiment to test this hypothesis, where trust and trustworthiness are measured using the sequential anonymous "trust game" with monetary payoffs. We find that oxytocin levels are higher in subjects who receive a monetary transfer that reflects an intention of trust relative to an unintentional monetary transfer of the same amount. In addition, higher oxytocin levels are associated with trustworthy behavior (the reciprocation of trust). Absent intentionality, both the oxytocin and behavioral responses are extinguished. We conclude that perceptions of intentions of trust affect levels of circulating oxytocin.
 
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