Please Scroll Down to See Forums Below
Oxytocin .... Intense orgasms!!!
- Thread starter John Juan
- Start date
John Juan
New member
It's great that they're coming up with ways to help those with autism.
John Juan
New member
Post in my oxytocin thread at pm...
"So far I like it as a nighttime , dose it before bed. As far as during the next day I do feel more like talking to people and BSing about nothing. Which is not like me. I don't feel sluggish at all in the morning. It could be because I'm dosing pretty low."
"So far I like it as a nighttime , dose it before bed. As far as during the next day I do feel more like talking to people and BSing about nothing. Which is not like me. I don't feel sluggish at all in the morning. It could be because I'm dosing pretty low."
John Juan
New member
GREAT STUDY ON OXYTOCIN AND ITS IMPORTANCE TO SKELETAL MUSCLE
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
AuthorsElabd C, et al. Show all Journal
Nat Commun. 2014 Jun 10;5:4082. doi: 10.1038/ncomms5082.
Abstract
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin-a hormone best known for its role in lactation, parturition and social behaviours-is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing.
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
AuthorsElabd C, et al. Show all Journal
Nat Commun. 2014 Jun 10;5:4082. doi: 10.1038/ncomms5082.
Abstract
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin-a hormone best known for its role in lactation, parturition and social behaviours-is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing.
markmark
New member
I have some sildenafil 100mg. {Viagra] mixed with oxytocin 125iu.
So it must have something to do with sex or erection for a pharmacy to mix the two.
I received this by mistake from a compounding pharmacy last year. order was replaced with just sildenafil and I kept the first order for free. I will try it at a quarter percent.
I received them in troches so don't know if the effects will be the same as injection. will keep you posted.
So it must have something to do with sex or erection for a pharmacy to mix the two.
I received this by mistake from a compounding pharmacy last year. order was replaced with just sildenafil and I kept the first order for free. I will try it at a quarter percent.
I received them in troches so don't know if the effects will be the same as injection. will keep you posted.
John Juan
New member
John Juan
New member
Making old muscles new again with Oxytocin By Patrick Arnold
Oxytocin is a relatively small peptide hormone (nine amino acids) that is produced in the posterior pituitary gland. Although it is produced in both men and women, the most well known function of oxytocin is in females where it acts as a facilitator of uterine contractions during labor, and as a stimulator of milk release from the breasts in the post-partum period. More recent research has implicated oxytocin in the emotional bonding response that occurs between females and their infant offspring, and also that which occurs with adult romantic partners over time. You may have heard that oxytocin is released after sex especially in women (which may be why women tend to be more affectionate afterwards). Oxytocin is also FDA approved as a drug to facilitate labor in women and to help with post childbirth bleeding.
Like many hormones in the body, science is discovering that oxytocin may have a wide variety of actions on multiple tissues – activities beyond the classical ones for which it is most well known. Most recently evidence has popped up suggesting that oxytocin is a factor in the regeneration of muscle tissue and that its levels are suppressed with age.
Researchers at UC Berkeley published a paper demonstrating that oxytocin is an indispensable factor in the healthy repair and maintenance of skeletal muscle tissue. They used young and old mice and showed that levels of oxytocin in the older mice were much lower than the younger mice. Administration of oxytocin (by subcutaneous injection) for a few days restored the ability of muscle to repair itself in these older mice to levels seen in younger mice. Conversely, mice bred with inability to produce oxytocin were born normal but quickly developed sarcopenia (muscle loss associated with aging).
The mechanism of this enhanced muscle regenerative capacity is thought to be due to increasing the proliferation and activation of muscle satellite cells. Muscle satellite cells are known to decrease with aging and they serve a key role in muscle recovery and growth. Injury (exercise induced or via trauma) causes the release of certain chemical signals which stimulate satellite cells to fuse with their parent muscle cells where they add myonuclei (the powerhouse of protein synthesis within the muscle cell).
It has been shown previously that muscle cells possess functional oxytocin receptors and that muscles themselves can manufacture oxytocin. One study in particular showed that in cattle the expression of oxytocin in muscle is increased dramatically in cattle receiving the anabolic steroid implant Revalor H, and it is speculated that oxytocin may be related to the increased muscle mass that results. The UC Berkeley study now shows that direct systemic administration of oxytocin may have positive effects upon skeletal muscle as well.
Oxytocin is a relatively small peptide hormone (nine amino acids) that is produced in the posterior pituitary gland. Although it is produced in both men and women, the most well known function of oxytocin is in females where it acts as a facilitator of uterine contractions during labor, and as a stimulator of milk release from the breasts in the post-partum period. More recent research has implicated oxytocin in the emotional bonding response that occurs between females and their infant offspring, and also that which occurs with adult romantic partners over time. You may have heard that oxytocin is released after sex especially in women (which may be why women tend to be more affectionate afterwards). Oxytocin is also FDA approved as a drug to facilitate labor in women and to help with post childbirth bleeding.
Like many hormones in the body, science is discovering that oxytocin may have a wide variety of actions on multiple tissues – activities beyond the classical ones for which it is most well known. Most recently evidence has popped up suggesting that oxytocin is a factor in the regeneration of muscle tissue and that its levels are suppressed with age.
Researchers at UC Berkeley published a paper demonstrating that oxytocin is an indispensable factor in the healthy repair and maintenance of skeletal muscle tissue. They used young and old mice and showed that levels of oxytocin in the older mice were much lower than the younger mice. Administration of oxytocin (by subcutaneous injection) for a few days restored the ability of muscle to repair itself in these older mice to levels seen in younger mice. Conversely, mice bred with inability to produce oxytocin were born normal but quickly developed sarcopenia (muscle loss associated with aging).
The mechanism of this enhanced muscle regenerative capacity is thought to be due to increasing the proliferation and activation of muscle satellite cells. Muscle satellite cells are known to decrease with aging and they serve a key role in muscle recovery and growth. Injury (exercise induced or via trauma) causes the release of certain chemical signals which stimulate satellite cells to fuse with their parent muscle cells where they add myonuclei (the powerhouse of protein synthesis within the muscle cell).
It has been shown previously that muscle cells possess functional oxytocin receptors and that muscles themselves can manufacture oxytocin. One study in particular showed that in cattle the expression of oxytocin in muscle is increased dramatically in cattle receiving the anabolic steroid implant Revalor H, and it is speculated that oxytocin may be related to the increased muscle mass that results. The UC Berkeley study now shows that direct systemic administration of oxytocin may have positive effects upon skeletal muscle as well.
John Juan
New member
Oxytocin increases trust in humans.
Authors
Kosfeld M1, Heinrichs M, Zak PJ, Fischbacher U, Fehr E.
Author information
Journal
Nature. 2005 Jun 2;435(7042):673-6.
Affiliation
Comment in
Nature. 2005 Jun 2;435(7042):571-2.
Rev Med Suisse. 2005 Jun 8;1(23):1592.
Abstract
Trust pervades human societies. Trust is indispensable in friendship, love, families and organizations, and plays a key role in economic exchange and politics. In the absence of trust among trading partners, market transactions break down. In the absence of trust in a country's institutions and leaders, political legitimacy breaks down. Much recent evidence indicates that trust contributes to economic, political and social success. Little is known, however, about the biological basis of trust among humans. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions. We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. On the contrary, oxytocin specifically affects an individual's willingness to accept social risks arising through interpersonal interactions. These results concur with animal research suggesting an essential role for oxytocin as a biological basis of prosocial approach behaviour.
Authors
Kosfeld M1, Heinrichs M, Zak PJ, Fischbacher U, Fehr E.
Author information
Journal
Nature. 2005 Jun 2;435(7042):673-6.
Affiliation
Comment in
Nature. 2005 Jun 2;435(7042):571-2.
Rev Med Suisse. 2005 Jun 8;1(23):1592.
Abstract
Trust pervades human societies. Trust is indispensable in friendship, love, families and organizations, and plays a key role in economic exchange and politics. In the absence of trust among trading partners, market transactions break down. In the absence of trust in a country's institutions and leaders, political legitimacy breaks down. Much recent evidence indicates that trust contributes to economic, political and social success. Little is known, however, about the biological basis of trust among humans. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions. We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. On the contrary, oxytocin specifically affects an individual's willingness to accept social risks arising through interpersonal interactions. These results concur with animal research suggesting an essential role for oxytocin as a biological basis of prosocial approach behaviour.
